Amber Brauer-Nikonow
YOU?
Author Swipe
View article: Vitamin B <sub>2</sub> Production by Vaginal Lactobacilli Promotes Symbiosis
Vitamin B <sub>2</sub> Production by Vaginal Lactobacilli Promotes Symbiosis Open
The human vaginal microbiome, particularly with lactobacilli as the main inhabitants, plays a key role in maintaining women’s health. While lactic acid-mediated pathogen exclusion is well known, broader metabolic functions of vaginal lacto…
View article: Development of a GC-MS/MS method to quantify 120 gut microbiota-derived metabolites
Development of a GC-MS/MS method to quantify 120 gut microbiota-derived metabolites Open
The gut microbiota produces metabolites that are important for host physiology and have critical roles in the development of diseases, such as metabolic disorders, cardiovascular diseases, and cancer. Here, we developed a gas chromatograph…
View article: Establishing an in vitro pipeline for the high-throughput quantification of epithelial permeability of gut bacterial metabolites
Establishing an in vitro pipeline for the high-throughput quantification of epithelial permeability of gut bacterial metabolites Open
The epithelium of the human gastrointestinal tract is key for controlling the absorption of small molecules and for forming a tight barrier between the gut microbiota and the host, thereby maintaining metabolic homeostasis. Both the microb…
View article: Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria Open
View article: Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco) Open
View article: Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria Open
Nitroxoline is a bacteriostatic quinoline antibiotic, considered a metal chelator inhibiting the activity of RNA-polymerase 1 . Its clinical indications are limited to uncomplicated urinary tract infections (UTIs), with a clinical suscepti…
View article: Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants
Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants Open
A major challenge in kidney transplantation (KT) is the large interpatient variability in the pharmacokinetics of immunosuppressive drugs. Here, we explored the role of the gut microbiome in interindividual variation in immunosuppressive d…
View article: Systematic analysis of drug combinations against Gram-positive bacteria
Systematic analysis of drug combinations against Gram-positive bacteria Open
View article: Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome
Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome Open
Highlights High throughput glycoproteomics method with multiplexed quantification 25-fold improvement of the mouse brain glycoproteome coverage Structural features dictate level of glycosite micro-heterogeneity Gut microbiome composition e…
View article: High-throughput profiling of drug interactions in Gram-positive bacteria
High-throughput profiling of drug interactions in Gram-positive bacteria Open
Drug combinations present a powerful strategy to tackle antimicrobial resistance, but have not been systematically tested in many bacterial species. Here, we used an automated high-throughput setup to profile ∼ 8000 combinations between 65…