Amber E. Carleton
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View article: The endo-lysosomal system drives lumen formation in a human epiblast model
The endo-lysosomal system drives lumen formation in a human epiblast model Open
The formation of a central lumen in the epiblast is a critical step that occurs during implantation in the human embryo. Lumen formation is accompanied by highly dynamic and complex cargo trafficking in the endo-lysosomal system. However, …
View article: Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification
Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that bone morphogenetic protein (BMP) signal…
View article: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Reviewer #2 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Reviewer #2 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Author response: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Author response: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Reviewer #3 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Reviewer #3 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Temporally resolved single cell transcriptomics in a human model of amniogenesis
Temporally resolved single cell transcriptomics in a human model of amniogenesis Open
Amniogenesis is triggered in a collection of pluripotent epiblast cells as the human embryo implants. To gain insights into the critical but poorly understood transcriptional machinery governing amnion fate determination, we examined the e…
View article: Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification
Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that bone morphogenetic protein (BMP) signal…
View article: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst
Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst Open
The formation of a central lumen in the human epiblast is a critical step for development. However, because the lumen forms in the epiblast coincident with implantation, the molecular and cellular events of this early lumenogenesis process…
View article: Spatially resolved cell polarity proteomics of a human epiblast model
Spatially resolved cell polarity proteomics of a human epiblast model Open
APEX2-based spatial proteomics identifies cell polarity proteome of hPSC-cysts, a 3D model of human epiblast cavity formation.