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View article: The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-year Growth Mixture Model Analysis
The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-year Growth Mixture Model Analysis Open
Anxiety is common in autistic people, yet little is known about its course beyond midlife due to limited longitudinal research. We analysed data from 5,270 adults aged 50–91 (median 62; 75% female) in the PROTECT study. Participants comple…
View article: Social isolation and loneliness in adults over 50 with high autistic traits.
Social isolation and loneliness in adults over 50 with high autistic traits. Open
Social isolation and loneliness are major public health issues, especially in old age, with serious health impacts. Some populations, such as autistic people, have been found to report high rates of social isolation and loneliness compared…
View article: Exploring Barriers and Facilitators to Antiretroviral Therapy Adherence among HIV-Positive Adolescents and Young Adults: A Descriptive Study at Buea Regional Hospital
Exploring Barriers and Facilitators to Antiretroviral Therapy Adherence among HIV-Positive Adolescents and Young Adults: A Descriptive Study at Buea Regional Hospital Open
Background: Despite all the strategies put in place by WHO and the International AIDS control program, such as free HIV screening and free distribution of ART’s, large numbers of adolescents and young adults still find it difficult to comp…
View article: Better Living with Non-memory-led Dementia: study protocol for a randomised controlled trial of a web-based caregiver educational programme (BELIDE trial)
Better Living with Non-memory-led Dementia: study protocol for a randomised controlled trial of a web-based caregiver educational programme (BELIDE trial) Open
Introduction Carers of people with non-memory-led dementias such as posterior cortical atrophy (PCA), primary progressive aphasia (PPA) and behavioural variant frontotemporal dementia (bvFTD) face unique challenges. Yet, little evidence-ba…
View article: Effectiveness of psychological interventions for young adults versus working age adults: a retrospective cohort study in a national psychological treatment programme in England
Effectiveness of psychological interventions for young adults versus working age adults: a retrospective cohort study in a national psychological treatment programme in England Open
UK National Institute for Health and Care Research.
View article: Prevalence of Post-Traumatic Stress Disorder (PTSD) in autistic children or young people (CYP) and adults: A systematic review and meta-analysis
Prevalence of Post-Traumatic Stress Disorder (PTSD) in autistic children or young people (CYP) and adults: A systematic review and meta-analysis Open
Autistic individuals are more likely to encounter traumatic events and mental health challenges throughout their lives. While multiple studies have explored the link between autism and post-traumatic stress disorder (PTSD), no meta-analysi…
View article: Effectiveness of psychological therapies for depression or anxiety in adults with intellectual disabilities: retrospective, matched, observational cohort study of primary care electronic healthcare records in England
Effectiveness of psychological therapies for depression or anxiety in adults with intellectual disabilities: retrospective, matched, observational cohort study of primary care electronic healthcare records in England Open
Background Treatment guidelines recommend evidence-based psychological therapies for adults with intellectual disabilities with co-occurring anxiety or depression. No previous research has explored the effectiveness of these therapies in m…
View article: Autistic Traits and Suicidality in Midlife and Old Age: Investigating Mediating Effects of Mental Health and Social Connectedness
Autistic Traits and Suicidality in Midlife and Old Age: Investigating Mediating Effects of Mental Health and Social Connectedness Open
Aims: Suicidality is increased among middle-aged and older autistic adults; however, little is known about underlying factors linking Autism with suicidality in midlife and older age. This is the first study to address this. Methods: A cro…
View article: Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14 Years Later: Findings From the UK Biobank
Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14 Years Later: Findings From the UK Biobank Open
Objectives Previous research investigating associations between life satisfaction and risk of Alzheimer's disease (AD) has been mixed. This association may differ depending on genetic risk for AD. The aim of this study was to test interact…
View article: Wellbeing and memory function: testing bidirectional associations in the English Longitudinal Study of Ageing (ELSA)
Wellbeing and memory function: testing bidirectional associations in the English Longitudinal Study of Ageing (ELSA) Open
Higher levels of wellbeing are associated with better memory function over 16 years. The study does not provide evidence that the association operates in the opposite direction. The lack of evidence for a relationship between memory and su…
View article: A record-linkage study of post-stroke primary care psychological therapy effectiveness in England
A record-linkage study of post-stroke primary care psychological therapy effectiveness in England Open
At least one-third of stroke survivors are affected by depression or anxiety, but no large-scale studies of real-world clinical practice have assessed whether psychological therapies are beneficial for these patients. Here we show that psy…
View article: A systematic review and thematic synthesis on the experiences of accessing and attending psychological therapy for informal carers of people living with dementia
A systematic review and thematic synthesis on the experiences of accessing and attending psychological therapy for informal carers of people living with dementia Open
Background Informal carers of people living with dementia are at a higher risk of experiencing mental health difficulties than the general population, yet many are not able to access timely psychological support and their psychological nee…
View article: Persistent Threat of Lassa Fever in Nigeria: Epidemiology, Challenges, and Strategies for Effective Management
Persistent Threat of Lassa Fever in Nigeria: Epidemiology, Challenges, and Strategies for Effective Management Open
Lassa fever is a viral hemorrhagic disease that poses a significant public health threat in Nigeria and West Africa. This review assesses the epidemiological trends, health impacts, and socioeconomic consequences of Lassa fever in Nigeria …
View article: Neurocognitive predictors of progression from late-life depression to all-cause dementia and Alzheimer’s disease: a systematic review and meta-analysis
Neurocognitive predictors of progression from late-life depression to all-cause dementia and Alzheimer’s disease: a systematic review and meta-analysis Open
Introduction Late-life depression (LLD) is consistently linked with higher risk of subsequent dementia (Livingston G et al. Lancet 2024; 404: 572-628); however, predictors of progression from LLD to dementia are yet to be identified. Objec…
View article: The Association Between Autism Spectrum Traits and Age-Related Spatial Working Memory Decline: A Large-Scale Longitudinal Study
The Association Between Autism Spectrum Traits and Age-Related Spatial Working Memory Decline: A Large-Scale Longitudinal Study Open
Background and Objectives Based on mixed findings from previous research, researchers have hypothesized autism may be a protective or risk factor for age-related cognitive decline/dementia, or that autism does not influence it (parallel ag…
View article: Assessing Compliance to Antiretroviral Therapy and Well-being among HIV-Positive Adolescents and Young Adults at Buea Regional Hospital
Assessing Compliance to Antiretroviral Therapy and Well-being among HIV-Positive Adolescents and Young Adults at Buea Regional Hospital Open
Despite initiatives by the WHO and the International AIDS Control Program, including free HIV screenings and antiretroviral therapy (ART), many adolescents and young adults struggle with treatment compliance. This study aimed to assess ART…
View article: Understanding Non-Compliance in Antiretroviral Therapy among HIV Positive Adolescents and Young Adults at Buea Regional Hospital: Challenges and Solutions
Understanding Non-Compliance in Antiretroviral Therapy among HIV Positive Adolescents and Young Adults at Buea Regional Hospital: Challenges and Solutions Open
In the light of considerable efforts by the WHO and various international AIDS control initiatives, a significant number of adolescents and young adults at Buea Regional Hospital continue to face challenges with adherence to antiretroviral…
View article: Depression and anxiety symptom change during psychological therapy for autistic clients: Evidence from national healthcare records in England
Depression and anxiety symptom change during psychological therapy for autistic clients: Evidence from national healthcare records in England Open
Background Autistic people appear less likely to benefit from currently-recommended mental health treatments. Intervention development and adaptation is hampered by a lack of knowledge regarding whether subgroups of autistic people differ …
View article: From Awareness to Barriers of Reporting Prevalence and Forms of Gender Based Violence among Adolescents in Conflict Settings
From Awareness to Barriers of Reporting Prevalence and Forms of Gender Based Violence among Adolescents in Conflict Settings Open
Background: The WHO highlights that barriers to reporting GBV include fear of stigma, lack of confidence in justice systems, and inadequate support service. Cultural norms and inadequate legal protections further hinder GBV reporting and s…
View article: Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study
Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study Open
Background Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental…
View article: The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-Year Growth Mixture Model Analysis
The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-Year Growth Mixture Model Analysis Open
View article: Dementia subtypes and suicidality: A systematic review and meta-analysis
Dementia subtypes and suicidality: A systematic review and meta-analysis Open
Further research is needed to understand what underlies the increased risks of suicidal ideation and suicide attempts for rarer subtypes.
View article: The effectiveness of psychological therapies for anxiety or depression, for people living with atypical dementia
The effectiveness of psychological therapies for anxiety or depression, for people living with atypical dementia Open
Background Prior research has highlighted that people living with dementia experiencing depression or anxiety can benefit from psychological therapies delivered in primary care. Yet, studies have mainly focused on common dementia types, le…
View article: Loneliness and Alzheimer’s disease: Testing associations using univariable and multivariable Mendelian randomisation models
Loneliness and Alzheimer’s disease: Testing associations using univariable and multivariable Mendelian randomisation models Open
Background Social isolation, encompassing factors like living alone and limited social contact, is associated with increased risk of Alzheimer’s disease (AD). One theory is that loneliness, which is the negative psychological affect often …
View article: Bidirectional relation of depressive symptoms and cognitive function over 16 years follow‐up
Bidirectional relation of depressive symptoms and cognitive function over 16 years follow‐up Open
Background Cognitive decline and depression often co‐occur among older adults, and they share several biological mechanisms. Despite that cognitive dysfunction has been linked to depression, the directionality of this association remains u…
View article: Access to primary care psychological therapy services for people living with dementia
Access to primary care psychological therapy services for people living with dementia Open
Background Psychological therapies are recommended for people living with dementia who experience depression or anxiety. However, people living with dementia often experience specific barriers to accessing services providing such intervent…
View article: Effectiveness of psychological therapies for depression and anxiety in atypical dementia
Effectiveness of psychological therapies for depression and anxiety in atypical dementia Open
INTRODUCTION People with dementia may benefit from psychological therapies for depression or anxiety, but evidence of their effectiveness in atypical dementia is limited. METHODS Using electronic health‐care records of > 2 million people w…
View article: Bidirectional changes in depressive symptoms and social functioning in older adults attending psychological therapy services
Bidirectional changes in depressive symptoms and social functioning in older adults attending psychological therapy services Open
Older adults receiving psychological therapy experience reductions in depressive symptoms and impairment in social functioning early in treatment. Treating core depressive symptoms and impairments in social functioning may benefit one anot…
View article: Evidence for causal links between known modifiable risk factors and dementia: A systematic review of Mendelian randomization studies
Evidence for causal links between known modifiable risk factors and dementia: A systematic review of Mendelian randomization studies Open
Background: We aimed to systematically review the evidence for causal associations between the known modifiable risk factors and dementia based on Mendelian randomization (MR) studies. Method: Five databases were searched from inception to…
View article: Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors Open
Dementia is a global health concern with increasing numbers of people living long enough to develop dementia. People with dementia (PwD) may be particularly vulnerable to suicidality. However, suicide in PwD has not been thoroughly explore…