Amber R. Philp YOU? Author Swipe

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Platelets regulate neural and oligodendroglial progenitors when infiltrating the brain parenchyma Open

Maria Anesti, Theodora Mourtzi, Dimitrios Dimitrakopoulos, Maria Nousia, Kyriaki Karassavidou , et al. · 2025

The mammalian, including the human, postnatal brain harbors distinct neurogenic and oligodendrogenic progenitor populations, whose activity during homeostasis and degeneration is closely related to blood vessels. Here, we investigated the …

Platelets During Myelin Repair in Multiple Sclerosis: Friend or Foe? Open

Francisco J. Rivera, Amber R. Philp, Carolina R. Reyes, Carlos Valenzuela‐Krugmann, Maria Elena Silva · 2025

Multiple sclerosis (MS) is an autoimmune neuroinflammatory demyelinating disease of the central nervous system (CNS) that affects more than 2.5 million people worldwide. Remyelination represents a robust regenerative response to myelin dam…

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment Open

Laura Remesal, Juliana Sucharov-Costa, Yuting Wu, Karishma Pratt, Gregor Bieri , et al. · 2025

Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2024

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…

Author response: Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2024

Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2024

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…

Author response: Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2024

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…

Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2023

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyeli…

Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2023

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…

Reviewer #2 (Public Review): Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2023

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyeli…

Reviewer #1 (Public Review): Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2023

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyeli…

Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open

Amber R. Philp, Carolina R. Reyes, Josselyne Mansilla, Amar Sharma, Chao Zhao , et al. · 2023

Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…

Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Open

Vinciane Saint‐Criq, Anita Guequén, Amber R. Philp, Sandra Villanueva, Tábata Apablaza , et al. · 2022

Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thic…

Author response: Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Open

Vinciane Saint‐Criq, Anita Guequén, Amber R. Philp, Sandra Villanueva, Tábata Apablaza , et al. · 2022

Inhibition of the sodium-dependent HCO <sub>3</sub> <sup>-</sup> transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Open

Vinciane Saint‐Criq, Anita Guequén, Amber R. Philp, Sandra Villanueva, Tábata Apablaza , et al. · 2021

Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thic…

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease Open

Génesis Vega, Anita Guequén, Amber R. Philp, Ambra Gianotti, Llilian Arzola , et al. · 2020

Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping airways free of infection and mucus obstruction. Airway surface liquid volume, ciliary beating, and mucus are central for proper MCC and critically regulated …

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways Open

Agustín Mansilla, Jaime Soto, Claudio Henríquez, Amber R. Philp, Marcus Mall , et al. · 2020

Tamoxifen is a drug of choice for treatment of breast cancer but it has also been reported to bear anti-inflammatory activity. Previously, we have observed that tamoxifen treatment successfully reduced inflammation in horses affected by eq…

Lack of<i>Kcnn4</i>improves mucociliary clearance in muco-obstructive lung disease Open

Génesis Vega, Anita Guequén, Amber R. Philp, Ambra Gianotti, Lilian Arzola , et al. · 2020

Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping the airways free of infection and mucus obstruction. Airways surface liquid (ASL) volume, ciliary beating and mucus are central for proper MCC, and are critic…

Corrigendum: Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium Open

Génesis Vega, Anita Guequén, Malin Johansson, Liisa Arike, Beatriz Martínez‐Abad , et al. · 2019

[This corrects the article DOI: 10.3389/fphys.2019.00694.].

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium Open

Génesis Vega, Anita Guequén, Malin Johansson, Liisa Arike, Beatriz Martínez‐Abad , et al. · 2019

Calcium-activated anion secretion is expected to ameliorate cystic fibrosis, a genetic disease that carries an anion secretory defect in exocrine tissues. Human patients and animal models of the disease that present a mild intestinal pheno…

Pericytes Favor Oligodendrocyte Fate Choice in Adult Neural Stem Cells Open

Maria Elena Silva, Simona Lange, Bryan Hinrichsen, Amber R. Philp, Carolina R. Reyes , et al. · 2019

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Upon demyelination, oligodendrocyte progenitor cells (OPCs) are activated and they proliferate, migrate and differentiate into myelin-pro…

Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse Open

Amber R. Philp, Texia T. Riquelme, Pamela Millar-Büchner, Rodrigo González, Francisco V. Sepúlveda , et al. · 2018

Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome Open

Pamela Millar-Büchner, Amber R. Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr , et al. · 2016

In summary, we showed that the colon is severely affected by Mecp2 silencing in mice. Changes in colon length and epithelial histology are similar to those observed in colitis. Changes in the localization of proteins that participate in fl…

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