Ambrin Farizah Babu
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View article: Metabolic Signatures in Lean MASLD: Current Insights and Future Directions
Metabolic Signatures in Lean MASLD: Current Insights and Future Directions Open
Lean metabolic dysfunction-associated steatotic liver disease (lean MASLD) challenges longstanding views that link hepatic steatosis primarily to obesity. Emerging as a distinct and under-recognized clinical entity, lean MASLD affects indi…
View article: Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry
Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry Open
Liquid chromatography‐mass spectrometry (LC–MS) is a powerful technique for the detection and quantification of methylated quaternary ammonium compounds (mQACs), such as acylcarnitines and methylated amino‐acid‐derived (betainized) compoun…
View article: Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption
Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption Open
View article: Corrigendum to “Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling” [Microbiol. Res. 283 (2024) 1–11]
Corrigendum to “Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling” [Microbiol. Res. 283 (2024) 1–11] Open
View article: Deep phenotyping of patients with MASLD upon high-intensity interval training
Deep phenotyping of patients with MASLD upon high-intensity interval training Open
Dutch Trial Register (registration number NL7932).
View article: Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling
Identification of metabolites produced by six gut commensal Bacteroidales strains using non-targeted LC-MS/MS metabolite profiling Open
View article: Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model
Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model Open
These data support the potential for using engineered microbial therapeutics in combination with dietary changes for managing MASLD.
View article: An integrated understanding of the metabolic benefits of a novel double-targeted genetically engineered probiotic expressing aldafermin intervention with dietary change on NAFLD
An integrated understanding of the metabolic benefits of a novel double-targeted genetically engineered probiotic expressing aldafermin intervention with dietary change on NAFLD Open
View article: Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression
Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression Open
Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains poorly understood due to the complex metabolic and inflammatory changes in the liver. This study aimed to elucidate hepatic events related to inflammation and lipid metabolism …
View article: Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition Open
The essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an interactive h…
View article: Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool
Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool Open
The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease (NAFLD), the most common liver disease worldwide, remain poorly understood. A non-targeted liquid chromatography-mass spectrometry (LC–MS)-based meta…
View article: Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis
Identification and Distribution of Sterols, Bile Acids, and Acylcarnitines by LC–MS/MS in Humans, Mice, and Pigs—A Qualitative Analysis Open
Sterols, bile acids, and acylcarnitines are key players in human metabolism. Precise annotations of these metabolites with mass spectrometry analytics are challenging because of the presence of several isomers and stereoisomers, variabilit…
View article: Tissue-wide Metabolomics Reveals Wide Impact of Gut Microbiota on Mice Metabolite Composition
Tissue-wide Metabolomics Reveals Wide Impact of Gut Microbiota on Mice Metabolite Composition Open
BackgroundThe essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an int…
View article: Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis
Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related Clinical Parameters: A Systematic Review and Meta-Analysis Open
One of the focuses of non-alcoholic fatty liver disease (NAFLD) treatment is exercise. Randomized controlled trials investigating the effects of exercise without dietary changes on NAFLD-related clinical parameters (liver parameters, lipid…
View article: Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition Open
The essential role of gut microbiota in health and disease is well-recognized, but the biochemical details underling beneficial impact remain largely undefined. Dysbiosis of gut bacteria results in the alteration of certain microbial and h…
View article: Rapid detection of microbiota cell type diversity using machine-learned classification of flow cytometry data
Rapid detection of microbiota cell type diversity using machine-learned classification of flow cytometry data Open
View article: “Notame”: Workflow for Non-Targeted LC–MS Metabolic Profiling
“Notame”: Workflow for Non-Targeted LC–MS Metabolic Profiling Open
Metabolomics analysis generates vast arrays of data, necessitating comprehensive workflows involving expertise in analytics, biochemistry and bioinformatics in order to provide coherent and high-quality data that enable discovery of robust…
View article: “NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling
“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling Open
Metabolomics analysis generates vast arrays of data, necessitating comprehensive workflows involving expertise in analytics, biochemistry and bioinformatics, in order to provide coherent and high-quality data that enables discovery of robu…
View article: Molecular Basis of Pulmonary Hypertension
Molecular Basis of Pulmonary Hypertension Open
Pulmonary hypertension is a life threatening incurable disorder. The advances in physiology, genetics, and molecular biology have greatly improved our understanding of the cellular and molecular mechanisms underlying the disorder. In this …
View article: Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?
Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture? Open
Agricultural industry uses pesticides to optimize food production for the growing human population. A major issue for crops is fungal phytopathogens, which are treated mainly with azole fungicides. Azoles are also the main medical treatmen…
View article: Screening, Production and Optimization of Extracellular Laccase Enzyme from Pleurotus Ostreatus
Screening, Production and Optimization of Extracellular Laccase Enzyme from Pleurotus Ostreatus Open
The enzyme laccase (p-diphenol: oxygenoxidoreductase; EC 1.10.3.2) is known to degrade many phenolic aromatic compounds. Many species of white rot fungi are well–known producers of the enzyme laccase. The first phase was the isolation of e…