Explanipedia

COVID-19 outbreak during investigation of acute respiratory syndrome among pilgrims in Senegal: An Integrated real time surveillance approach Open

Abdou Padane, Aminata Mboup, Seyni Ndiaye, Marièma Sarr, Marilyne Aza-Gnandji , et al. · 2024

Background: Since the COVID-19 outbreak, global efforts have focused on controlling the disease. However, intense cross border movements pose a risk for the emergence of new SARS-CoV-2 strains. Recent example is the detection of cases amon…

Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti Open

Sahal Darar Dirir, Ambroise D. Ahouidi, Aboubacry Dramé, Warsama Osman Abdi, Guelleh Youssouf Kayad , et al. · 2024

BACKGROUND In endemic areas, vertical transmission of hepatitis B virus (HBV) remains a major source of the global reservoir of infected people. Eliminating mother-to-child transmission (MTCT) of HBV is at the heart of World Health Organiz…

Next-generation sequencing survey of acute febrile illness in Senegal (2020–2022) Open

Gregory S. Orf, Ambroise D. Ahouidi, M. de la Mata, Cyrille K. Diédhiou, Aminata Mboup , et al. · 2024

Introduction Acute febrile illnesses (AFI) in developing tropical and sub-tropical nations are challenging to diagnose due to the numerous causes and non-specific symptoms. The proliferation of rapid diagnostic testing and successful contr…

Specific Mutations Identified in Patients Vaccinated and Infected with COVID-19 in Senegal Open

Abdou Padane, Djibril Wade, Cyrille K. Diédhiou, Marièma Sarr, Seyni Ndiaye , et al. · 2024

Background: Vaccination against SARS-CoV-2 is currently the best preventive measure to control the COVID-19 pandemic. However, in some cases, it appeared that despite the vaccination, some people were reinfected. Aim: The objective of this…

An emerging clade of Chikungunya West African genotype discovered in real-time during 2023 outbreak in Senegal Open

Abdou Padane, Houriiyah Tegally, Yajna Ramphal, Ndiaye Seyni, Marièma Sarr , et al. · 2023

Chikungunya (CHIKV) is a re-emerging endemic arbovirus in West Africa. Since July 2023, Senegal and Burkina Faso have been experiencing an ongoing outbreak, with over 300 confirmed cases detected so far in the regions of Kédougou and Tamba…

Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates Open

Antoine Claessens, Lindsay B. Stewart, Eleanor Drury, Ambroise D. Ahouidi, Alfred Amambua‐Ngwa , et al. · 2023

Experimental studies on the biology of malaria parasites have mostly been based on laboratory-adapted lines, but there is limited understanding of how these may differ from parasites in natural infections. Loss-of-function mutants have pre…

Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples Open

Muzamil Mahdi Abdel Hamid, Mohamed Hassan Abdelraheem, Desmond Omane Acheampong, Ambroise D. Ahouidi, Mozam Ali , et al. · 2023

We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malar…

Seroprevalence of Hepatitis B Virus Infection and Associated Factors among Pregnant Women Attending Antenatal Care centers in Djbouti City, Republic of Djibouti Open

Sahal Darar Dirir, Ambroise D. Ahouidi, M. Miguil · 2023

Background: Hepatitis B virus (HBV) remains a major public health concern affecting millions of people worldwide. More than 90% of infections are acquired during infancy through perinatal transmission leading to chronicity and possibility …

Genomic variation during culture-adaptation of genetically complex<i>Plasmodium falciparum</i>clinical isolates Open

Antoine Claessens, Lindsay B. Stewart, Eleanor Drury, Ambroise D. Ahouidi, Alfred Amambua‐Ngwa , et al. · 2022

Experimental studies on the biology of malaria parasites have been mostly based on laboratory-adapted lines, but there is limited understanding of how these may differ from parasites in natural infections. Loss-of-function mutants have pre…

Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes Open

Suzanne Hocking, Lindsay B. Stewart, Aline Fréville, Adam J. Reid, Sarah J. Tarr , et al. · 2022

These findings contribute to understanding malaria parasite antigenic and developmental variation, focusing on the merozoite surface protein encoded by the single locus under strongest balancing selection. Analyzing the initial ex vivo gen…

Evolution of SARS-CoV-2 Strains in Senegal: From a Wild Wuhan Strain to the Omicron Variant Open

Khadim Gueye, Abdou Padane, Cyrille K. Diédhiou, Samba Ndiour, Ndéye Diabou Diagne , et al. · 2022

The coronavirus disease 2019 (COVID-19) is a contagious disease caused by a new coronavirus called SARS-CoV-2. The first case was discovered in Wuhan, China, in December 2019, raising concerns about the emergence of a new coronavirus that …

Dynamics of Variants of Concern (VOC) of SARS-CoV-2 during the Different Waves of COVID-19 in Senegal Open

Abdou Padane, Cyrille Kouligeul Diedhiou, Khadim Gueye, Samba Ndiour, Ndéye Diabou Diagne , et al. · 2022

Background: In Senegal, the incidence of SARS-CoV-2 evolved with four successive epidemic waves. The first wave started in March 2020 with low virus variability, whilst the second outbreak, which started in December 2020, was dominated by …

Heterogeneity of the Omicron variant in Senegal Open

Cyrille K. Diédhiou, Abdou Padane, Khadim Gueye, Samba Ndiour, Aminata Mboup , et al. · 2022

Transcriptome analysis of diverse <i>Plasmodium falciparum</i> clinical isolates identifies genes correlating with highly variable expression of merozoite surface protein MSPDBL2 Open

Suzanne Hocking, Lindsay B. Stewart, Sarah J. Tarr, Aline Fréville, Kevin K. A. Tetteh , et al. · 2022

The merozoite surface protein MSPDBL2 of Plasmodium falciparum is under strong balancing selection and is a target of naturally acquired antibodies. Remarkably, MSPDBL2 is expressed in only a minority of mature schizonts of any cultured pa…

Detection of SARS-CoV-2 variants by Abbott molecular, antigen, and serological tests Open

Mary A. Rodgers, Alessandro Olivo, Barbara J. Harris, Chris Lark, Xinxin Luo , et al. · 2022

Rapidly rising cases with Omicron in Senegal Open

Abdou Padane, Moustapha Mbow, Aminata Mboup, Cyrille K. Diédhiou, Khadim Gueye , et al. · 2022

The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe Open

Lester J. Pérez, Gregory S. Orf, Michael G. Berg, Mary A. Rodgers, Todd Meyer , et al. · 2022

Molecular surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing in west Africa, especially in the Republic of Senegal. Here, we present a molecular epidemiology study of the early waves of SARS-CoV-2 infec…

Seroprevalence of SARS-CoV-2 IgG antibodies in a healthcare setting during the first pandemic wave in Senegal Open

Ambroise D. Ahouidi, Mark Anderson, Cyrille K. Diédhiou, Aminata Dia, Moustapha Mbow , et al. · 2021

This study investigated the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) immunoglobulin G (IgG) during the first pandemic wave in Senegal. The seroprevalence rate of SARS-CoV-2 IgG was assessed in 10 citie…

Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal Open

Ambroise D. Ahouidi, Mary A. Rodgers, Abdou Padane, Nafissatou Lèye, Alessandro Olivo , et al. · 2021

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations,…

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples Open

Ambroise D. Ahouidi, Mozam Ali, Jacob Almagro‐Garcia, Alfred Amambua‐Ngwa, Chanaki Amaratunga , et al. · 2021

MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from …

Emergence of Novel Combinations of SARS-CoV-2 Spike Receptor Binding Domain Variants in Senegal Open

Ambroise D. Ahouidi, Mary A. Rodgers, Abdou Padane, Nafissatou Lèye, Alessandro Olivo , et al. · 2021

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations,…

Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal Open

Ambroise D. Ahouidi, Rafael Oliveira, Lis Lobo, Cyrille K. Diédhiou, Souleymane Mboup , et al. · 2021

Background Delayed Plasmodium falciparum parasite clearance has been associated with Single Nucleotide Polymorphisms (SNPs) in the kelch protein propeller domain (coded by pfk13 gene). SNPs in the Plasmodium falciparum multidrug resistance…

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples Open

Ambroise D. Ahouidi, Mozam Ali, Jacob Almagro‐Garcia, Alfred Amambua‐Ngwa, Chanaki Amaratunga , et al. · 2021

MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from…

Evaluation an immunofluorescence-based antigen test for hospital point-of-care diagnosis of SARS-CoV-2 infection Open

Moustapha Mbow, Papa Alioune Badara Dieye, Ndeye Khady Ba, Marouba Cisse, Gora Lô , et al. · 2021

Genetic diversity of Plasmodium falciparum in Grande Comore Island Open

Nasserdine Papa Mze, Hervé Bogreau, Cyrille K. Diédhiou, Vendela Herdell, Silai Rahamatou , et al. · 2020

Genetic diversity of Plasmodium falciparum in Grande Comore Island Open

Nasserdine Papa Mze, Hervé Bogreau, Cyrille K. Diédhiou, Vendela Herdell, Silai Rahamatou , et al. · 2020

Background Despite several control interventions resulting in a considerable decrease in malaria prevalence in the Union of the Comoros, the disease remains a public health problem with high transmission in Grand Comore compared to neighbo…

Genetic diversity of Plasmodium falciparum in Grande Comore Island Open

Nasserdine Papa Mze, Hervé Bogreau, Cyrille K. Diédhiou, Vendela Herdell, Silai Rahamatou , et al. · 2020

Background Despite several control interventions resulting in a considerable decrease in malaria prevalence in the Union of the Comoros, the disease remains a public health problem with high transmission in Grand Comore compared to neighbo…

Comparison of Poisson and zero-inflated Poisson model fits. Open

Francisco Y. Cai, Tiffany M. DeSimone, Elsa Hansen, Cameron V. Jennings, Amy K. Bei , et al. · 2020

For each invasion assay, the empirical distribution of the number of parasites in a red blood cell was used to fit a Poisson model and a zero-inflated Poisson model. Model fits were compared using a likelihood ratio test. The p-values (N =…

Additional modeling details. Open

Francisco Y. Cai, Tiffany M. DeSimone, Elsa Hansen, Cameron V. Jennings, Amy K. Bei , et al. · 2020

Mathematical descriptions of the compartmental model used to simulate within-host infection dynamics and the Boolean-Poisson model used to estimate physical accessibility. (DOCX)

Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains Open

Francisco Y. Cai, Tiffany M. DeSimone, Elsa Hansen, Cameron V. Jennings, Amy K. Bei , et al. · 2020

The growth of the malaria parasite Plasmodium falciparum in human blood causes all the symptoms of malaria. To proliferate, non-motile parasites must have access to susceptible red blood cells, which they invade using pairs of parasite lig…

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