Explanipedia

D3.1 Implementation of the Information Hub – the FRAMEwork online knowledge and action platform Open

Gregory D. Hager, Andrew Simmons, A. Subash, B Giralt, Joan Masó · 2023

FRAMEwork online knowledge and action platform set up, developed based on a comprehensive deliberation of user requirements, derived from workshops within the consortium and mock-ups tested with lead farmers of FCs.

You read my mind: fMRI markers of threatening appraisals in people with persistent psychotic experiences Open

Raphael Underwood, Liam Mason, Owen O’Daly, Jeff Dalton, Andrew Simmons , et al. · 2021

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease Open

Young Ho Park, Angela Hodges, Andrew Simmons, Simon Lovestone, Michael W. Weiner , et al. · 2020

The study is rated Class III because of the case control design and the risk of spectrum bias.

Genome‐wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology Open

Kwangsik Nho, Kelly Nudelman, Mariet Allen, Angela Hodges, Sungeun Kim , et al. · 2020

Introduction Abnormal gene expression patterns may contribute to the onset and progression of late‐onset Alzheimer's disease (LOAD). Methods We performed transcriptome‐wide meta‐analysis (N = 1440) of blood‐based microarray gene expression…

The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study Open

Gustav Mårtensson, Daniel Ferreira, Tobias Granberg, Lena Cavallin, Ketil Oppedal , et al. · 2020

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease Open

Genevera I. Allen, Nicola Amoroso, Catalina Anghel, Venkatachalapathy S. K. Balagurusamy, Christopher J. Bare , et al. · 2020

Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer’s Disease. The Alzheimer’s Disease DREAM Challenge was designed as a computational crowdsourced project t…

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease Open

Genevera I. Allen, Nicola Amoroso, Catalina Anghel, Venkatachalapathy S. K. Balagurusamy, Christopher J. Bare , et al. · 2020

Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer’s Disease. The Alzheimer’s Disease DREAM Challenge was designed as a computational crowdsourced project t…

Dysregulated Fc gamma receptor–mediated phagocytosis pathway in Alzheimer's disease: network-based gene expression analysis Open

Young Ho Park, Angela Hodges, Shannon L. Risacher, Kuang Lin, Jae‐Won Jang , et al. · 2019

O4‐10‐02: DYSREGULATED FC GAMMA R‐MEDIATED PHAGOCYTOSIS PATHWAY IN ALZHEIMER'S DISEASE: NETWORK‐BASED GENE EXPRESSION ANALYSIS Open

Young Ho Park, Angela Hodges, Shannon L. Risacher, Kuang Lin, Simon Lovestone , et al. · 2019

Dysregulated expression patterns of many genes are implicated in the onset and progression of Alzheimer's disease (AD). How these genes jointly affect AD is still unclear. Here we performed network-based gene expression and enrichment anal…

IC‐P‐057: DYSREGULATED FC GAMMA R‐MEDIATED PHAGOCYTOSIS PATHWAY IN ALZHEIMER'S DISEASE: NETWORK‐BASED GENE EXPRESSION ANALYSIS Open

Young Ho Park, Angela Hodges, Shannon L. Risacher, Kuang Lin, Simon Lovestone , et al. · 2019

Dysregulated expression patterns of many genes are implicated in the onset and progression of Alzheimer's disease (AD). How these genes jointly affect AD is still unclear. Here we performed network-based gene expression and enrichment anal…

Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study Open

Lena Lim, Heledd Hart, Henrietta Howells, Mitul A. Mehta, Andrew Simmons , et al. · 2019

Background: Childhood abuse is associated with structural brain abnormalities. Few studies have investigated white matter tract abnormalities in medication-naive, drug-free individuals who experienced childhood abuse. We examined the assoc…

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease Open

Virginia Boccardi, Eric Westman, Luca Pelini, Olof Lindberg, J‐Sebastian Muehlboeck , et al. · 2019

Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions - in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4. <…

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process? Open

Theo G.M. van Erp, Esther Walton, Derrek P. Hibar, Lianne Schmaal, Wenhao Jiang , et al. · 2018

Stability of graph theoretical measures in structural brain networks in Alzheimer’s disease Open

Gustav Mårtensson, Joana B. Pereira, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki , et al. · 2018

Frontostriatal Dysfunction During Decision Making in Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder Open

Luke Norman, Christina Carlisi, Anastasia Christakou, Clodagh M. Murphy, Kaylita Chantiluke , et al. · 2018

The findings suggest shared deficits in using learned reward expectancies to guide decision making, as well as shared dysfunction in medio-fronto-striato-limbic brain regions. However, findings of unique dysfunction in the ventromedial orb…

Frontoparietal Tracts Linked to Lateralized Hand Preference and Manual Specialization Open

Henrietta Howells, Michel Thiebaut de Schotten, Flavio Dell’Acqua, Ahmad Beyh, Giuseppe Zappalà , et al. · 2018

Humans show a preference for using the right hand over the left for tasks and activities of everyday life. While experimental work in non-human primates has identified the neural systems responsible for reaching and grasping, the neural ba…

Heterogeneous patterns of brain atrophy in Alzheimer's disease Open

Konstantinos Poulakis, Joana B. Pereira, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki , et al. · 2018

There is increasing evidence showing that brain atrophy varies between patients with Alzheimer's disease (AD), suggesting that different anatomical patterns might exist within the same disorder. We investigated AD heterogeneity based on co…

Altered Functional Connectivity of Fronto-Cingulo-Striatal Circuits during Error Monitoring in Adolescents with a History of Childhood Abuse Open

Heledd Hart, Lena Lim, Mitul A. Mehta, Charles Curtis, Xiaohui Xu , et al. · 2018

Childhood maltreatment is associated with error hypersensitivity. We examined the effect of childhood abuse and abuse-by-gene (5-HTTLPR, MAOA) interaction on functional brain connectivity during error processing in medication/drug-f…

Brain structure in women at risk of postpartum psychosis: an MRI study Open

Montserrat Fusté, Astrid Pauls, Amanda Worker, Antje A. T. S. Reinders, Andrew Simmons , et al. · 2017

Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse Open

Heledd Hart, Lena Lim, Mitul A. Mehta, Antonia Chatzieffraimidou, Charles Curtis , et al. · 2017

Childhood maltreatment is associated with attention deficits. We examined the effect of childhood abuse and abuse-by-gene (5-HTTLPR, MAOA, FKBP5) interaction on functional brain connectivity during sustained attention in medication/drug-fr…

Spatio-Temporal Reference Frames as Geographic Objects Open

Andrew Simmons, Rajesh Vasa · 2017

It is often desirable to analyse trajectory data in local coordinates relative to a reference location. Similarly, temporal data also needs to be transformed to be relative to an event. Together, temporal and spatial contextualisation perm…

Shared and Disorder-Specific Neurocomputational Mechanisms of Decision-Making in Autism Spectrum Disorder and Obsessive-Compulsive Disorder Open

Christina Carlisi, Luke Norman, Clodagh M. Murphy, Anastasia Christakou, Kaylita Chantiluke , et al. · 2017

Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) often share phenotypes of repetitive behaviors, possibly underpinned by abnormal decision-making. To compare neural correlates underlying decision-making between these …

Neural dysfunction during temporal discounting in paediatric Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder Open

Luke Norman, Christina Carlisi, Anastasia Christakou, Kaylita Chantiluke, Clodagh M. Murphy , et al. · 2017

Both Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are associated with choice impulsivity, i.e. the tendency to prefer smaller immediate rewards over larger delayed rewards. However, the extent to …

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease Open

Emrin Horgusluoglu, Kwangsik Nho, Shannon L. Risacher, Sungeun Kim, Tatiana Foroud , et al. · 2017

The Evans’ Index revisited: New cut-off levels for use in radiological assessment of ventricular enlargement in the elderly Open

Maiken K. Brix, Eric Westman, Andrew Simmons, Geir Ringstad, Per Kristian Eide , et al. · 2017

The range of the EI measurements in healthy elderly is wide, and a cut-off value of 0.3 cannot be used to differentiate between normal and enlarged ventricles in individual cases. The proposed EI thresholds from the present study show good…

Clinical utility of magnetic resonance imaging in first-episode psychosis Open

Irina Falkenberg, Stefania Benetti, Marie Raffin, Phillipe Wuyts, William Pettersson‐Yeo , et al. · 2017

Background There is no consensus as to whether magnetic resonance imaging (MRI) should be used as part of the initial clinical evaluation of patients with first-episode psychosis (FEP). Aims (a) To assess the logistical feasibility of rout…

Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder Open

Christina Carlisi, Luke Norman, Clodagh M. Murphy, Anastasia Christakou, Kaylita Chantiluke , et al. · 2017

Background Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, …

Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications Open

Daniel Ferreira, C. Verhagen, Juan Hernández, Lena Cavallin, Chunjie Guo , et al. · 2017

Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer’s disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking…

A ‘Disease Severity Index’ to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia Open

Daniel Ferreira, Farshad Falahati, Cecilia Linden, Rachel F. Buckley, Kathryn A. Ellis , et al. · 2017

Subjective memory decline (SMD) is a heterogeneous condition. While SMD might be the earliest sign of Alzheimer’s disease (AD), it also occurs in aging and various neurological, medical, and psychiatric conditions. Identifying those with h…

A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer’s Disease Open

Wasim Khan, Vincent Giampietro, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde , et al. · 2017

The apolipoprotein E (APOE) gene has been consistently shown to modulate the risk of Alzheimer's disease (AD). Here, using an AD and normal aging dataset primarily consisting of three AD multi-center studies (n = 1,781), we compared the ef…

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