Amedea Manfredi
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View article: β-cyclodextrin based platform for bimodal detection of o-toluidine and cholesterol: Electrochemical and fluorescence sensing
β-cyclodextrin based platform for bimodal detection of o-toluidine and cholesterol: Electrochemical and fluorescence sensing Open
A novel dual-mode sensor based on the in-situ coupling of electrochemical (EC) and fluorescence (FL) assay for o-toluidine and cholesterol detection is reported. The detection platform was constructed by assembling nitrogen doped graphene …
View article: Use of calcium chloride to enhance the efficacy of polyamidoamines as flame retardants for cotton
Use of calcium chloride to enhance the efficacy of polyamidoamines as flame retardants for cotton Open
The role of metal ions in improving the flame resistance of cotton prompted to investigate whether adding CaCl2 to the glycine-derived polyamidoamine M-GLY, an excellent intumescent flame retardant for cotton, increased its efficacy in thi…
View article: On the Suitability of Phosphonate-Containing Polyamidoamines as Cotton Flame Retardants
On the Suitability of Phosphonate-Containing Polyamidoamines as Cotton Flame Retardants Open
A novel polyamidoamine (M-PCASS) bearing a disulfide group and two phosphonate groups per repeat unit was obtained by reacting N,N′-methylenebisacrylamide with a purposely designed bis-sec-amine monomer, namely, tetraethyl(((disulfanediylb…
View article: Silk/Polyamidoamine Membranes for Removing Chromium VI from Water
Silk/Polyamidoamine Membranes for Removing Chromium VI from Water Open
Polyamidoamine hydrogels prepared by the radical post-polymerization of α,ω-bisacrylamide-terminated M-AGM oligomers, in turn obtained by the polyaddition of 4-aminobutylguanidine with N,N’-methylenebisacrylamide, were reinforced with raw …
View article: Toughening Polyamidoamine Hydrogels through Covalent Grafting of Short Silk Fibers
Toughening Polyamidoamine Hydrogels through Covalent Grafting of Short Silk Fibers Open
Linear amphoteric polyamidoamines (PAAs) are usually water-soluble, biodegradable and biocompatible. Crosslinked PAAs form in water hydrogels, retaining most of the favorable properties of their linear counterparts. The hydrogels prepared …
View article: Nanosponges by the oxo-Michael polyaddition of cyclodextrins as sorbents of water pollutants: the o-toluidine case
Nanosponges by the oxo-Michael polyaddition of cyclodextrins as sorbents of water pollutants: the o-toluidine case Open
Hydrophilic cyclodextrin nanosponges were prepared by the oxo-Michael polyaddition in an aqueous solution at pH > 10 of α-, β-, and γ-cyclodextrin with 1,4-bisacryloylpiperazine or 2,2-bisacrylamidoacetic acid. These nanosponges and, for c…
View article: L-Arginine-Derived Polyamidoamine Oligomers Bearing at Both Ends β-Cyclodextrin Units as pH-Sensitive Curcumin Carriers
L-Arginine-Derived Polyamidoamine Oligomers Bearing at Both Ends β-Cyclodextrin Units as pH-Sensitive Curcumin Carriers Open
The aza-Michael polyaddition of L-arginine and N,N′-methylene-bis-acrylamide gives the biocompatible and easily cell-internalized polyamidoamine ARGO7. By controlled synthesis, two ARGO7 oligomers, namely a trimer and a pentamer, bearing a…
View article: Nanosized T1 MRI Contrast Agent Based on a Polyamidoamine as Multidentate Gd Ligand
Nanosized T1 MRI Contrast Agent Based on a Polyamidoamine as Multidentate Gd Ligand Open
A linear polyamidoamine (PAA) named BAC-EDDS, containing metal chelating repeat units composed of two tert-amines and four carboxylic groups, has been prepared by the aza-Michael polyaddition of ethylendiaminodisuccinic (EDDS) with 2,2-bis…
View article: Semi-Crystalline Hydrophobic Polyamidoamines: A New Family of Technological Materials?
Semi-Crystalline Hydrophobic Polyamidoamines: A New Family of Technological Materials? Open
The hitherto known polyamidoamines (PAAs) are not suitable as structural materials because they are usually water-soluble or swellable in water. This paper deals with the synthesis and characterization of semi-crystalline hydrophobic PAAs …
View article: Highlight on the Mechanism of Linear Polyamidoamine Degradation in Water
Highlight on the Mechanism of Linear Polyamidoamine Degradation in Water Open
This paper aims at elucidating the degradation mechanism of linear polyamidoamines (PAAs) in water. PAAs are synthesized by the aza-Michael polyaddition of prim-monoamines or bis-sec-amines with bisacrylamides. Many PAAs are water-soluble …
View article: Hydrogen Bonding in a l-Glutamine-Based Polyamidoamino Acid and its pH-Dependent Self-Ordered Coil Conformation
Hydrogen Bonding in a l-Glutamine-Based Polyamidoamino Acid and its pH-Dependent Self-Ordered Coil Conformation Open
This paper reports on synthesis, acid–base properties, and self-structuring in water of a chiral polyamidoamino acid, M-l-Gln, obtained from the polyaddition of N,N′-methylenebisacrylamide with l-glutamine, with the potential of establishi…
View article: Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules
Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules Open
Gold nanoparticles are elective candidate for cancer therapy. Current efforts are devoted to developing innovative methods for their synthesis. Besides, understanding their interaction with cells have become increasingly important for thei…
View article: Controlled Synthesis of Linear Polyamidoamino Acids
Controlled Synthesis of Linear Polyamidoamino Acids Open
Polyamidoamino acids (PAACs) are synthetic polymers prepared by the polyaddition of bisacrylamides with natural α-amino acids, which in the process maintain both their chirality and their amphoteric nature. This polymerization process is s…
View article: Development of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites
Development of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites Open
peer reviewed
View article: d-, l- and d,l-Tryptophan-Based Polyamidoamino Acids: pH-Dependent Structuring and Fluorescent Properties
d-, l- and d,l-Tryptophan-Based Polyamidoamino Acids: pH-Dependent Structuring and Fluorescent Properties Open
Chiral polyamidoamino acids were obtained by polyaddition of N,N’-methylenebisacrylamide with d-, d,l- and l-tryptophan (M-d-Trp, M-d,l-Trp and M-l-Trp). l-tryptophan/glycine copolymers, M-G-l-Trp5, M-G-l-Trp10, M-G-l-Trp20 and M-G-l-Trp40…
View article: Self-Structuring in Water of Polyamidoamino Acids with Hydrophobic Side Chains Deriving from Natural α-Amino Acids
Self-Structuring in Water of Polyamidoamino Acids with Hydrophobic Side Chains Deriving from Natural α-Amino Acids Open
This paper reports on synthesis, acid-base properties and self-structuring in water of chiral polyamidoamino acids (PAACs) obtained by polyaddition of N,N′-methylenebisacrylamide with l-alanine, l-valine and l-leucine (M-l-Ala, M-l-Val, M-…
View article: Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs
Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs Open
Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of …
View article: The AGMA1 polyamidoamine mediates the efficient delivery of siRNA
The AGMA1 polyamidoamine mediates the efficient delivery of siRNA Open
AGMA1, a prevailingly cationic, guanidine-bearing, linear, amphoteric polyamidoamine is an effective siRNA condensing agent. Here two AGMA1 samples of different molecular weight, i.e. AGMA1-5 and AGMA1-10 were evaluated as siRNA condensing…
View article: Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases
Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases Open
Glucocorticoids are widely prescribed in treatment of rheumatoid arthritis, asthma, systemic lupus erythematosus, lymphoid neoplasia, skin and eye inflammations. However, well-documented adverse effects offset their therapeutic advantages.…
View article: Linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases
Linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases Open
The initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. Blocking the latter with high-affinity ligands may inhibit infection. DC-SIGN, a C-type lectin receptor expressed by immature…