Amelia Rushton
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View article: Identification of actionable targets using <scp>DEPArray</scp> ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded tissues followed by shallow whole‐genome sequencing
Identification of actionable targets using <span>DEPArray</span> ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded tissues followed by shallow whole‐genome sequencing Open
Formalin‐fixed paraffin‐embedded (FFPE) tissue specimens represent precious resources for clinical genomic profiling studies, especially when coupled with comprehensive medical records. Even though next‐generation sequencing (NGS) is an ef…
View article: A Rapid, Shallow Whole Genome Sequencing Workflow Applicable to Limiting Amounts of Cell-Free DNA
A Rapid, Shallow Whole Genome Sequencing Workflow Applicable to Limiting Amounts of Cell-Free DNA Open
Background Somatic copy number alterations (sCNAs) acquired during the evolution of breast cancer provide valuable prognostic and therapeutic information. Here we present a workflow for screening sCNAs using picogram amounts of cell-free D…
View article: c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis Open
Background and Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a tumor suppressor. …
View article: Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer Open
Background We report copy-number profiling by low-pass WGS (LP-WGS) in individual circulating tumour cells (CTCs) for guiding treatment in patients with metastatic breast cancer (MBC), comparing CTC results with mutations detected in circu…
View article: Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease
Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease Open
PURPOSE We investigated the utility of the Oncomine Breast cfDNA Assay for detecting circulating tumor DNA (ctDNA) in women from a breast screening population, including healthy women with no abnormality detected by mammogram, and women on…
View article: A Review of Circulating Tumour Cell Enrichment Technologies
A Review of Circulating Tumour Cell Enrichment Technologies Open
Circulating tumour cells (CTCs) are the precursor cells for the formation of metastatic disease. With a simple blood draw, liquid biopsies enable the non-invasive sampling of CTCs from the blood, which have the potential to provide importa…