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View article: Intraoperative hypotension and postoperative delirium among older high-risk patients undergoing major noncardiac surgery: a retrospective single-centre cohort study
Intraoperative hypotension and postoperative delirium among older high-risk patients undergoing major noncardiac surgery: a retrospective single-centre cohort study Open
Although intraoperative hypotension initially appeared to be associated with postoperative delirium, this association was no longer significant when accounting for temporal improvements in perioperative care. Intraoperative hypotension may…
View article: Patient preference for intraoperative opioid use and early recovery after noncardiac surgery: protocol for a randomised factorial design trial of opioid-free versus opioid-based anaesthesia (the PERFECT trial)
Patient preference for intraoperative opioid use and early recovery after noncardiac surgery: protocol for a randomised factorial design trial of opioid-free versus opioid-based anaesthesia (the PERFECT trial) Open
View article: Investigating the effectiveness of an intraoperative decision support guided fluid therapy intervention on postoperative outcome of high-risk patients undergoing high-risk abdominal surgery: protocol for an international multicentre stepped-wedge cluster-randomised implementation trial
Investigating the effectiveness of an intraoperative decision support guided fluid therapy intervention on postoperative outcome of high-risk patients undergoing high-risk abdominal surgery: protocol for an international multicentre stepped-wedge cluster-randomised implementation trial Open
View article: Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery
Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery Open
Importance Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence lead…
View article: Pulmonary thromboendarterectomy: The Marie Lannelongue Hospital experience
Pulmonary thromboendarterectomy: The Marie Lannelongue Hospital experience Open
Multimodal therapy approach to CTEPH patients did not affect effectiveness of PEA. Medical therapy and BPA could act in synergy with surgery to treat more challenging patients.
View article: Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure
Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure Open
Introduction: Over time and despite optimal medical management of patients with pulmonary hypertension (PH), the right ventricle (RV) function deteriorates from an adaptive to maladaptive phenotype, leading to RV failure (RVF). Although RV…
View article: Hydroxyethyl starch for perioperative goal-directed fluid therapy in 2020: a narrative review
Hydroxyethyl starch for perioperative goal-directed fluid therapy in 2020: a narrative review Open
Background Perioperative fluid management – including the type, dose, and timing of administration –directly affects patient outcome after major surgery. The objective of fluid administration is to optimize intravascular fluid status to ma…
View article: Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19
Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19 Open
View article: Effect of pneumoperitoneum on dynamic variables of fluid responsiveness (Delta PP and PVI) during Trendelenburg position
Effect of pneumoperitoneum on dynamic variables of fluid responsiveness (Delta PP and PVI) during Trendelenburg position Open
Background and Aims: Pulse pressure variation (ΔPP) is considered as one of the best predictors of fluid responsiveness in patients under mechanical ventilation. Pleth Variability Index (PVI) has been proposed as a noninvasive alternative.…
View article: Pleth variability index versus pulse pressure variation for intraoperative goal-directed fluid therapy in patients undergoing low-to-moderate risk abdominal surgery: a randomized controlled trial
Pleth variability index versus pulse pressure variation for intraoperative goal-directed fluid therapy in patients undergoing low-to-moderate risk abdominal surgery: a randomized controlled trial Open
View article: Automated Titration of Vasopressor Infusion Using a Closed-loop Controller
Automated Titration of Vasopressor Infusion Using a Closed-loop Controller Open
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Multiple studies have reported associations between intraoperative hypotension and adverse postoperative complications. One of the…
View article: Long-term Impact of Crystalloid versus Colloid Solutions on Renal Function and Disability-free Survival after Major Abdominal Surgery
Long-term Impact of Crystalloid versus Colloid Solutions on Renal Function and Disability-free Survival after Major Abdominal Surgery Open
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background The authors recently demonstrated that administration of balanced hydroxyethyl starch solution as part of intraoperative goal-dire…
View article: In Reply
In Reply Open
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View article: Crystalloid versus Colloid for Intraoperative Goal-directed Fluid Therapy Using a Closed-loop System
Crystalloid versus Colloid for Intraoperative Goal-directed Fluid Therapy Using a Closed-loop System Open
Background The type of fluid and volume regimen given intraoperatively both can impact patient outcome after major surgery. This two-arm, parallel, randomized controlled, double-blind, bi-center superiority study tested the hypothesis that…
View article: Perioperative goal directed therapy using automated closed-loop fluid management: the future?
Perioperative goal directed therapy using automated closed-loop fluid management: the future? Open
Although surgery has become much safer, it has also becoming increasingly more complex and perioperative complications continue to impact millions of patients worldwide each year. Perioperative hemodynamic optimization utilizing Goal Dire…