Amélie Heneman-Masurel
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View article: Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response
Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response Open
View article: Intronic polyadenylation isoforms in the 5’ part of genes constitute a source of microproteins and are involved in cell response to cisplatin
Intronic polyadenylation isoforms in the 5’ part of genes constitute a source of microproteins and are involved in cell response to cisplatin Open
Transcript isoforms generated by intronic polyadenylation (IPA) are widely regulated in various biological processes and often encode protein isoforms. Microproteins are small proteins translated from small open reading frames (sORFs) in n…
View article: Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death
Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death Open
Auranofin (Ridaura®, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thiore…
View article: Compartment-specific and ELAVL1-coordinated regulation of intronic polyadenylation isoforms by doxorubicin
Compartment-specific and ELAVL1-coordinated regulation of intronic polyadenylation isoforms by doxorubicin Open
Intronic polyadenylation (IPA) isoforms, which contain alternative last exons, are widely regulated in various biological processes and by many factors. However, little is known about their cytoplasmic regulation and translational status. …
View article: Causative Links between Protein Aggregation and Oxidative Stress: A Review
Causative Links between Protein Aggregation and Oxidative Stress: A Review Open
Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer’s disease, Parkinson’s disease, and prion disease.…
View article: Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death
Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death Open
View article: Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer Open
The combination of AUF and VC, two commonly available drugs, could be efficient against triple-negative breast cancer and potentially other cancers with similar redox properties and PTGR1 expression levels. The redox-based anticancer activ…
View article: Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer Open
The combination of AUF and VC, two commonly available drugs, could be efficient against triple-negative breast cancer and potentially other cancers with similar redox properties and PTGR1 expression levels. The redox-based anticancer activ…
View article: Fe‐S Clusters Emerging as Targets of Therapeutic Drugs
Fe‐S Clusters Emerging as Targets of Therapeutic Drugs Open
Fe‐S centers exhibit strong electronic plasticity, which is of importance for insuring fine redox tuning of protein biological properties. In accordance, Fe‐S clusters are also highly sensitive to oxidation and can be very easily altered i…
View article: Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins
Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins Open
Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes. In both de novo and therapy-related APL, the most frequent PML breakpoints are located withi…