Amélie M. Julé
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View article: Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis
Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis Open
These data highlight how innate reprogramming during 'sterile' inflammatory diseases contributes to chronicity, uncovering pathways unique to endogenous immune triggers that could provide disease-specific points of intervention without eng…
View article: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
Wnt signaling plays crucial roles in embryonic patterning including the regulation of convergent extension (CE) during gastrulation, the establishment of the dorsal axis, and later, craniofacial morphogenesis. Further, Wnt signaling is a c…
View article: Author response: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Author response: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
View article: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
Wnt signaling plays crucial roles in embryonic patterning including the regulation of convergent extension during gastrulation, the establishment of the dorsal axis, and later, craniofacial morphogenesis. Further, Wnt signaling is a crucia…
View article: Author response: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Author response: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
View article: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
Wnt signaling plays a crucial role in the early embryonic patterning and development, to regulate convergent extension during gastrulation and the establishment of the dorsal axis. Further, Wnt signaling is a crucial regulator of craniofac…
View article: Author response: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Author response: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
View article: Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis
Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis Open
Background Regulatory B cells (Bregs) play a pivotal role in suppressing immune responses, yet there is still a lack of cell surface markers that can rigorously identify them. In mouse models for multiple sclerosis (MS), TIM-1 or TIGIT exp…
View article: 50. Discovery Of Wnt And Calcium Regulation Of Midfacial Morphogenesis
50. Discovery Of Wnt And Calcium Regulation Of Midfacial Morphogenesis Open
Purpose: The intricate process of craniofacial development is orchestrated by the WNT signaling pathway, which directly impacts the formation and anomalies of orofacial structures. Within this pathway, the adapter proteins DACT1 and DACT2 …
View article: Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis Open
Wnt signaling plays crucial roles in embryonic patterning including the regulation of convergent extension (CE) during gastrulation, the establishment of the dorsal axis, and later, craniofacial morphogenesis. Further, Wnt signaling is a c…
View article: dact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development
dact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development Open
Wnt signaling plays a crucial role in the early embryonic patterning and development, to regulate convergent extension during gastrulation and the establishment of the dorsal axis. Further, Wnt signaling is a crucial regulator of craniofac…
View article: Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection Open
View article: Genetic requirement of <i>dact1/2</i> to regulate noncanonical Wnt signaling and <i>calpain 8</i> during embryonic convergent extension and craniofacial morphogenesis
Genetic requirement of <i>dact1/2</i> to regulate noncanonical Wnt signaling and <i>calpain 8</i> during embryonic convergent extension and craniofacial morphogenesis Open
Wnt signaling plays crucial roles in embryonic patterning including the regulation of convergent extension during gastrulation, the establishment of the dorsal axis, and later, craniofacial morphogenesis. Further, Wnt signaling is a crucia…
View article: Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease
Nasal polyp antibody-secreting cells display proliferation signature in aspirin-exacerbated respiratory disease Open
View article: Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Background The optic nerve is an important tissue in glaucoma and the unmyelinated nerve head region remains an important site of many early neurodegenerative changes. In both humans and mice, astrocytes constitute the major glial cell typ…
View article: Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis Open
T peripheral helper (Tph) cells, identified in the synovium of adults with seropositive rheumatoid arthritis, drive B cell maturation and antibody production in non-lymphoid tissues. We sought to determine if similarly dysregulated T cell-…
View article: Additional file 6 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 6 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 6: Supplementary Table 4. Differentially expressed genes and significant pathways identified in ONH 30 vs 7 days.
View article: Additional file 7 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 7 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 7: Supplementary Table 5. Differerentially expressed genes and significant pathways identified in ONH 30 vs 0 days.
View article: Additional file 11 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 11 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 11: Supplementary Table 9. Differentially expressed genes and pathways identified in ONP 30 vs 0 days.
View article: Additional file 9 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 9 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 9: Supplementary Table 7. Differentially expressed genes and pathways identified in ONP 30 vs 7 days.
View article: Additional file 5 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 5 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 5: Supplementary Table 3. Differentially expressed genes in pairwise comparisons of ONH 7 vs 0 days.
View article: Additional file 10 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 10 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 10: Supplementary Table 8. Common differentially expressed genes in all three timpoint comparisons in the ONP.
View article: Additional file 12 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 12 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 12: Supplementary Table 10. Pathways differentiating ONH astrocytes from those in the ONP at 30 days.
View article: Additional file 4 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 4 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 4: Supplementary Table 2. Differential expression analysis using a likelihood ratio test (LRT) focusing on genes in the ONH that differ over time (0, 7 and 30 days) in microbead injected mice.
View article: Additional file 8 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
Additional file 8 of Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure Open
Additional file 8: Supplementary Table 6. Differentially expressed genes and significant pathways identified in ONP 7 vs 0 days.
View article: Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes
Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes Open
Much of what we know about astrocyte form and function is derived from the study of gray matter protoplasmic astrocytes, whereas white matter fibrous astrocytes remain relatively unexplored. Here, we used the ribotag approach to isolate ri…
View article: The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children Open
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with…
View article: SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children
SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children Open
View article: Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children
Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children Open
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcome were previously correlated with …
View article: Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis Open
We sought to determine the immunophenotype of joint-infiltrating CD4+ T cells as well as the stability of Tregs in oligo JIA. This was done through the use of flow cytometry, bulk and single-cell RNA sequencing, DNA methylation studies, an…