Amelie Stadelmann
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View article: Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding
Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding Open
CutA, a conserved protein across all domains of life, has been suggested to be involved in copper tolerance in bacteria, though recent studies have questioned this association, leaving its biological role unknown. To clarify its function, …
View article: Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding
Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding Open
CutA, a conserved protein across all domains of life, has long been linked to copper tolerance in Escherichia coli , though recent studies question this association. To clarify its function, we studied cutA knockout mutants from two phylog…
View article: Mapping temperature‐sensitive mutations at a genome scale to engineer growth switches in <i>Escherichia coli</i>
Mapping temperature‐sensitive mutations at a genome scale to engineer growth switches in <i>Escherichia coli</i> Open
Temperature‐sensitive (TS) mutants are a unique tool to perturb and engineer cellular systems. Here, we constructed a CRISPR library with 15,120 Escherichia coli mutants, each with a single amino acid change in one of 346 essential protein…
View article: Purine nucleotide limitation undermines antibiotic action in clinical<i>Escherichia coli</i>
Purine nucleotide limitation undermines antibiotic action in clinical<i>Escherichia coli</i> Open
Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics 1–4 and promote evolution of antimicrobial resistance (AMR) 5,6 . However, little is known about which metabolic pathways contribute to …