Amélie Vergnol
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View article: GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD
GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD Open
Duchenne muscular dystrophy (DMD) is a fatal disease caused by dystrophin deficiency, leading to degeneration of the entire musculature. To improve muscle pathophysiology and gene therapy for DMD, we investigated the potential of growth di…
View article: Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance
Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance Open
Voltage-gated Ca2+ channels (VGCCs) are regulated by four CaVβ subunits (CaVβ1–CaVβ4), each showing specific expression patterns in excitable cells. While primarily known for regulating VGCC function, CaVβ proteins also have channel-indepe…
View article: The CaVβ1 isoforms : role in neuromuscular junction formation and implication in Myotonic Dystrophy type 1 pathophysiology
The CaVβ1 isoforms : role in neuromuscular junction formation and implication in Myotonic Dystrophy type 1 pathophysiology Open
Quatre protéines CaVβ (CaVβ1 à CaVβ4) sont connues comme des sous-unités régulatrices des canaux Ca2+ dépendants du voltage (Voltage-gated Ca2+ Channels, VGCC), chacune ayant des profils d'expression spécifiques selon leur fonction. Bien q…
View article: GDF5 as a rejuvenating treatment for age-related neuromuscular failure
GDF5 as a rejuvenating treatment for age-related neuromuscular failure Open
Sarcopenia involves a progressive loss of skeletal muscle force, quality and mass during ageing, which results in increased inability and death; however, no cure has been established thus far. Growth differentiation factor 5 (GDF5) has bee…
View article: Genome-wide association mapping within a local <i>Arabidopsis thaliana</i> population more fully reveals the genetic architecture for defensive metabolite diversity
Genome-wide association mapping within a local <i>Arabidopsis thaliana</i> population more fully reveals the genetic architecture for defensive metabolite diversity Open
A paradoxical finding from genome-wide association studies (GWAS) in plants is that variation in metabolite profiles typically maps to a small number of loci, despite the complexity of underlying biosynthetic pathways. This discrepancy may…
View article: New Insights in CaVβ Subunits: Role in the Regulation of Gene Expression and Cellular Homeostasis
New Insights in CaVβ Subunits: Role in the Regulation of Gene Expression and Cellular Homeostasis Open
The voltage-gated calcium channels (CaVs or VGCCs) are fundamental regulators of intracellular calcium homeostasis. When electrical activity induces their activation, the influx of calcium that they mediate or their interaction with intrac…
View article: Genome-wide association mapping within a single <i>Arabidopsis thaliana</i> population reveals a richer genetic architecture for defensive metabolite diversity
Genome-wide association mapping within a single <i>Arabidopsis thaliana</i> population reveals a richer genetic architecture for defensive metabolite diversity Open
A paradoxical finding from genome-wide association studies (GWAS) in plants is that variation in metabolite profiles typically maps to a small number of loci, despite the complexity of underlying biosynthetic pathways. This discrepancy may…