Amélie Wegener
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View article: Long-term outcomes of ventral hernia repair using a new prosthetic mesh
Long-term outcomes of ventral hernia repair using a new prosthetic mesh Open
BACKGROUND: Recently, use of hybrid meshes has been proposed owing to its different mesh-related properties. This study reviews our longer term experience with a hybrid mesh. MATERIALS AND METHODS: We retrospectively reviewed all patients …
View article: Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model
Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model Open
The KN Motif and AnKyrin Repeat Domain 1 (KANK1) is proposed as a tumour suppressor gene, as its expression is reduced or absent in several types of tumour tissue, and over-expressing the protein inhibited the proliferation of tumour cells…
View article: Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination
Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination Open
Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Sc…
View article: Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming
Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming Open
Despite progress, our understanding of psychiatric and neurological illnesses remains poor, at least in part due to the inability to access neurons directly from patients. Currently, there are in vitro models available but significa…
View article: Sp2 is the only glutamine‐rich specificity protein with minor impact on development and differentiation in myelinating glia
Sp2 is the only glutamine‐rich specificity protein with minor impact on development and differentiation in myelinating glia Open
Oligodendrocytes and Schwann cells are the myelinating glia of the vertebrate nervous system and by generation of myelin sheaths allow rapid saltatory conduction. Previous in vitro work had pointed to a role of the zinc finger containing s…
View article: Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells
Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells Open
Oligodendrocytes are the myelinating glia of the central nervous system and ensure rapid saltatory conduction. Shortage or loss of these cells leads to severe malfunctions as observed in human leukodystrophies and multiple sclerosis, and t…