Ami Buikema
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View article: Longitudinal analyses of healthcare resource utilization and costs among patients with obstructive hypertrophic cardiomyopathy
Longitudinal analyses of healthcare resource utilization and costs among patients with obstructive hypertrophic cardiomyopathy Open
Patients with oHCM experience substantial HCRU and costs over 5 years of follow-up. These results indicate a need for new treatment options which could decrease HCRU and improve patient outcomes.
View article: Research Method, Conduct, and Reporting Considerations for Improving the Quality of Non-Hypothesis-Evaluating Treatment Effectiveness Analyses Using Real-World Data: An ISPOR Working Group Report
Research Method, Conduct, and Reporting Considerations for Improving the Quality of Non-Hypothesis-Evaluating Treatment Effectiveness Analyses Using Real-World Data: An ISPOR Working Group Report Open
We conclude that existing guidance documents, although they were largely developed for HETE studies, are highly useful for the broad range of non-HETE RWD analyses as well.
View article: P-2076. COVID-19 Vaccination Patterns and Timing among Privately Insured Pregnant Persons, 2020-2023
P-2076. COVID-19 Vaccination Patterns and Timing among Privately Insured Pregnant Persons, 2020-2023 Open
Background Pregnant people with COVID-19 are at higher risk of severe illness, pregnancy complications, and adverse pregnancy outcomes. While maternal COVID-19 vaccination has been shown to be safe and effective for pregnant people and the…
View article: P-2046. Integrating Immunization Information System (IIS) and commercial health insurance claims data to improve COVID-19 vaccination capture among pregnant people
P-2046. Integrating Immunization Information System (IIS) and commercial health insurance claims data to improve COVID-19 vaccination capture among pregnant people Open
Background Several COVID-19 vaccine safety and effectiveness studies have used real-world data (RWD), including health insurance claims to delineate people’s vaccination history. However, COVID-19 vaccine administration is not completely c…
View article: Development and electronic health record validation of an algorithm for identifying patients with Duchenne muscular dystrophy in US administrative claims
Development and electronic health record validation of an algorithm for identifying patients with Duchenne muscular dystrophy in US administrative claims Open
BACKGROUND: Muscular dystrophies (MDs) comprise a heterogenous group of genetically inherited conditions characterized by progressive muscle weakness and increasing disability. The lack of separate diagnosis codes for Duchenne MD (DMD) and…
View article: Meningococcal Vaccination Rates Among People With a New Diagnosis of HIV Infection in the US
Meningococcal Vaccination Rates Among People With a New Diagnosis of HIV Infection in the US Open
This cohort study suggests that MenACWY vaccine uptake among people with a new diagnosis of HIV was low, highlighting the need to educate patients and clinicians about the recommendations for conditions such as HIV infection that increase …
View article: Low Meningococcal Vaccination Rates Among Patients With Newly Diagnosed Complement Component Deficiencies in the United States
Low Meningococcal Vaccination Rates Among Patients With Newly Diagnosed Complement Component Deficiencies in the United States Open
Meningococcal vaccination is recommended for patients with complement component deficiencies (CDs) in the United States. In this retrospective database study, only 4.6% and 2.2% of patients received MenACWY and MenB vaccination, respective…
View article: 478 Overall survival associated with BRCA or ATM mutation status in patients with ovarian cancer: findings from the PRIOR-2 study
478 Overall survival associated with BRCA or ATM mutation status in patients with ovarian cancer: findings from the PRIOR-2 study Open
Introduction/Background* Many clinical guidelines recommend patients with ovarian cancer (OC) undergo mutational testing of genes involved in DNA damage repair response as a predictive marker of clinical benefit from platinum-based chemoth…
View article: 451 Patient characteristics and treatment patterns by BRCA/ATM mutation status in ovarian cancer patients: an EHR analysis in the PRIOR-2 study
451 Patient characteristics and treatment patterns by BRCA/ATM mutation status in ovarian cancer patients: an EHR analysis in the PRIOR-2 study Open
Introduction/Background* Previous studies have reported median progression-free survival (PFS) of 12-18 months in ovarian cancer (OC). Testing for BRCA1/2 or ATM gene mutations in OC can inform treatment choice. Data on the treatment exper…
View article: Racial and ethnic disparity in clinical outcomes among patients with confirmed COVID-19 infection in a large US electronic health record database
Racial and ethnic disparity in clinical outcomes among patients with confirmed COVID-19 infection in a large US electronic health record database Open
Racial/ethnic minority patients with COVID-19 had more severe disease on initial presentation than White patients. Increased mortality risk was attenuated by hospitalization among Black patients but not Asian patients, indicating that outc…
View article: Development and validation of a drug adherence index for COPD
Development and validation of a drug adherence index for COPD Open
BACKGROUND: Inhaled medications are the mainstay of treatment for chronic obstructive pulmonary disease (COPD). Despite their importance, adherence to these medications is low. Low adherence is linked to increased exacerbation rates, morta…
View article: Meningococcal vaccination in patients with newly diagnosed asplenia in the United States
Meningococcal vaccination in patients with newly diagnosed asplenia in the United States Open
Meningococcal vaccination rates among newly diagnosed asplenia patients were low, highlighting the need to educate providers about the recommendations for high-risk conditions and ensure healthcare access for vulnerable patients.
View article: <p>Healthcare Resource Utilization, Exacerbations, and Readmissions Among Medicare Patients with Chronic Obstructive Pulmonary Disease After Long-Acting Muscarinic Antagonist Therapy Initiation with Soft Mist versus Dry Powder Inhalers</p>
Healthcare Resource Utilization, Exacerbations, and Readmissions Among Medicare Patients with Chronic Obstructive Pulmonary Disease After Long-Acting Muscarinic Antagonist Therapy Initiation with Soft Mist versus Dry Powder Inhalers Open
SMI initiators had significantly fewer COPD-related exacerbations than DPI initiators. In addition, lower odds of readmissions were observed following COPD-related hospitalizations among the SMI cohort, as compared with the DPI cohort.
View article: 26. Factors Associated with Meningococcal Vaccination among Patients with Newly Diagnosed High-Risk Conditions
26. Factors Associated with Meningococcal Vaccination among Patients with Newly Diagnosed High-Risk Conditions Open
Background Vaccination is recommended for persons at increased risk for invasive meningococcal disease (IMD) due to complement component deficiency (CD), asplenia or human immunodeficiency virus (HIV) infection. However, uptake of quadriva…
View article: Differences in Real-World Health and Economic Outcomes Among Patients with COPD Treated with Combination Tiotropium/Olodaterol Versus Triple Therapy
Differences in Real-World Health and Economic Outcomes Among Patients with COPD Treated with Combination Tiotropium/Olodaterol Versus Triple Therapy Open
This study was sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI). Palli and Franchino-Elder are employees of BIPI. Frazer, DuCharme, Buikema, and Anderson are employees of Optum, which was contracted by BIPI to conduct this st…
View article: Meeting Abstracts - AMCP 2020
Meeting Abstracts - AMCP 2020 Open
The abstracts presented in this program were originally slated to be presented at the AMCP 2020 meeting in Houston, Texas, April 21-24. The meeting was canceled because of the COVID-19 crisis. In lieu of the scheduled poster presentations,…
View article: Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2019
Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2019 Open
AMCP Nexus 2019: The Intersection of Value and Care, in National Harbor, MD, is expected to attract more than 2,400 managed care pharmacists and other health care professionals who manage and evaluate drug therapies, develop and manage net…
View article: 2747. Relative Vaccine Efficacy of High-Dose vs. Standard Dose Influenza Vaccines in Preventing Probable Influenza in a US Medicare Fee-for-Service Population
2747. Relative Vaccine Efficacy of High-Dose vs. Standard Dose Influenza Vaccines in Preventing Probable Influenza in a US Medicare Fee-for-Service Population Open
Background High dose (HD) influenza vaccine has been shown to be more efficacious than standard dose (SD) vaccine in multiple randomized trials. HD is currently the most commonly used vaccine in US seniors (≥65 years of age). In this study…
View article: 2726. Meningococcal Vaccination Among Patients Newly Diagnosed at High-Risk for Meningococcal Disease in the United States
2726. Meningococcal Vaccination Among Patients Newly Diagnosed at High-Risk for Meningococcal Disease in the United States Open
Background Quadrivalent conjugate and polysaccharide meningococcal vaccines (MenACWY) have been recommended in the United States for patients at high-risk due to functional or anatomic asplenia, complement component deficiency (CD) and hum…
View article: Costs, exacerbations and pneumonia after initiating combination tiotropium olodaterol versus triple therapy for chronic obstructive pulmonary disease
Costs, exacerbations and pneumonia after initiating combination tiotropium olodaterol versus triple therapy for chronic obstructive pulmonary disease Open
Aim: To compare health plan-paid costs, exacerbations and pneumonia outcomes for patients with chronic obstructive pulmonary disease (COPD) initiating combination tiotropium olodaterol (TIO + OLO) versus triple therapy (TT: long-acting mus…
View article: The effect of delaying initiation with umeclidinium/vilanterol in patients with COPD: an observational administrative claims database analysis using marginal structural models
The effect of delaying initiation with umeclidinium/vilanterol in patients with COPD: an observational administrative claims database analysis using marginal structural models Open
Background: Chronic obstructive pulmonary disease (COPD) is associated with high clinical and economic burden. Optimal pharmacological therapy for COPD aims to reduce symptoms and the frequency and severity of exacerbations. Umeclidinium/v…