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View article: Common and rare variant genetic contributions in African Americans with autism
Common and rare variant genetic contributions in African Americans with autism Open
The absence of non-European cohorts in genetic studies of neurodevelopmental and neuropsychiatric disorders severely limits the understanding of their full genetic architecture and undermines implementation of precision medicine. Here, we …
View article: Diagnosis of Autism—Reply
Diagnosis of Autism—Reply Open
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA C…
View article: Development and Replication of Objective Measurements of Social Visual Engagement to Aid in Early Diagnosis and Assessment of Autism
Development and Replication of Objective Measurements of Social Visual Engagement to Aid in Early Diagnosis and Assessment of Autism Open
Importance Autism spectrum disorder is a common and early-emerging neurodevelopmental condition. While 80% of parents report having had concerns for their child’s development before age 2 years, many children are not diagnosed until ages 4…
View article: Eye-Tracking–Based Measurement of Social Visual Engagement Compared With Expert Clinical Diagnosis of Autism
Eye-Tracking–Based Measurement of Social Visual Engagement Compared With Expert Clinical Diagnosis of Autism Open
Importance In the US, children with signs of autism often experience more than 1 year of delay before diagnosis and often experience longer delays if they are from racially, ethnically, or economically disadvantaged backgrounds. Most diagn…
View article: Infant‐directed song potentiates infants’ selective attention to adults’ mouths over the first year of life
Infant‐directed song potentiates infants’ selective attention to adults’ mouths over the first year of life Open
The mechanisms by which infant‐directed (ID) speech and song support language development in infancy are poorly understood, with most prior investigations focused on the auditory components of these signals. However, the visual components …
View article: Measuring state-level infant and toddler well-being in the United States: Gaps in data lead to gaps in understanding
Measuring state-level infant and toddler well-being in the United States: Gaps in data lead to gaps in understanding Open
Children who are nurtured, protected, and supported in the first years of life tend to have better individual outcomes and are more likely to grow to become healthy, productive adults. Child well-being varies across states, yet the field l…
View article: Frontiers in the research of autism pathogenesis.
Frontiers in the research of autism pathogenesis. Open
This review focuses on four interrelated teams and research lines that form the basis for new research on the pathogenesis of autism spectrum disorder (ASD) at the Marcus Autism Center, in Atlanta (US). These themes probe typical social be…
View article: Early social communication development in infants with autism spectrum disorder
Early social communication development in infants with autism spectrum disorder Open
Social‐communication differences are a robust and defining feature of autism spectrum disorder (ASD) but identifying early points of divergence in infancy has been a challenge. The current study examines social communication in 9‐ to 12‐mo…
View article: Common genetic variants on 5p14.1 associate with autism spectrum disorders
Common genetic variants on 5p14.1 associate with autism spectrum disorders Open
Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and neuropsychiatric disorders characterized by deficits in verbal communication, impairment of social interaction, and restricted and repetitive patterns o…
View article: Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder
Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder Open
Early intervention has been established as efficacious in addressing developmental delays in young children with autism spectrum disorder. Evidence that caregiver-implemented interventions are feasible and effective for young children with…
View article: Behavioral predictors of autism recurrence are genetically independent and influence social reciprocity: evidence that polygenic ASD risk is mediated by separable elements of developmental liability
Behavioral predictors of autism recurrence are genetically independent and influence social reciprocity: evidence that polygenic ASD risk is mediated by separable elements of developmental liability Open
The preponderance of causal influence on total population attributable risk for autism is polygenic in nature, but it is not known how such liability engenders the development of the syndrome. In 348 epidemiologically ascertained toddler t…
View article: Research Review: Outcomes of 24‐ to 36‐month‐old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta‐analysis
Research Review: Outcomes of 24‐ to 36‐month‐old children with autism spectrum disorder vary by ascertainment strategy: a systematic review and meta‐analysis Open
Background Despite widespread recommendations for early surveillance of risk for autism spectrum disorder ( ASD ), no research to date has shown that early surveillance leads to better clinical outcomes. Preliminary research has suggested …
View article: Early emergence of discrepancy in adaptive behavior and cognitive skills in toddlers with autism spectrum disorder
Early emergence of discrepancy in adaptive behavior and cognitive skills in toddlers with autism spectrum disorder Open
Individuals with autism spectrum disorder and average IQ exhibit a widening discrepancy between lagging adaptive skills relative to their cognitive potential, but it is unknown when this discrepancy emerges in development. To address this …
View article: Topology of the Structural Social Brain Network in Typical Adults
Topology of the Structural Social Brain Network in Typical Adults Open
Although a large body of research has identified discrete neuroanatomical regions involved in social cognition and behavior (the "social brain"), the existing findings are based largely on studies of specific brain structures defined withi…
View article: Biomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health
Biomarkers in Autism Spectrum Disorder: Challenges, Advances, and the Need for Biomarkers of Relevance to Public Health Open
Although autism spectrum disorder (ASD) is the most strongly genetic of all complex neuropsychiatric disorders, it is still defined and diagnosed behaviorally. The vast genotypic and phenotypic heterogeneity of the condition necessitate a …
View article: An agenda for 21st century neurodevelopmental medicine: lessons from autism.
An agenda for 21st century neurodevelopmental medicine: lessons from autism. Open
The future of neurodevelopmental medicine has the potential of situating child neurology at the forefront of a broad-based public health effort to optimize neurodevelopmental outcomes of children born with high-prevalence and diverse genet…
View article: Mechanisms of Diminished Attention to Eyes in Autism
Mechanisms of Diminished Attention to Eyes in Autism Open
The results falsify the gaze aversion hypothesis; instead, at the time of initial diagnosis, diminished eye-looking in autism is consistent with passive insensitivity to the social signals in others' eyes.