Ami Yamamoto
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View article: Application of Model Core Potentials to Zn- and Mg-containing Metalloproteins in the Fragment Molecular Orbital Method
Application of Model Core Potentials to Zn- and Mg-containing Metalloproteins in the Fragment Molecular Orbital Method Open
The fragment molecular orbital (FMO) method enables quantum mechanical calculations for macromolecules by dividing the target into fragments. However, most calculations, even for metalloproteins, have been performed by removing metal ions …
View article: Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7 Open
Necrosis in the tumor interior is a common feature of aggressive cancers that is associated with poor clinical prognosis and the development of metastasis. How the necrotic core promotes metastasis remains unclear. Here, we report that eme…
View article: Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters
Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters Open
Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells while maintaining contacts with one another. Collective metas…
View article: Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells
Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells Open
We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human a…
View article: Special feature of COVID-19 in FMODB: Fragment molecular orbital calculations and interaction energy analysis of SARS-CoV-2 related proteins
Special feature of COVID-19 in FMODB: Fragment molecular orbital calculations and interaction energy analysis of SARS-CoV-2 related proteins Open
SARS-CoV-2 is the causative agent of coronavirus, globally known as COVID-19. There are ongoing researches to develop effective therapeutics and vaccines against COVID-19 using various methods. We currently conduct research based on the fr…
View article: Special feature of COVID-19 in FMODB: Fragment molecular orbital calculations and interaction energy analysis of SARS-CoV-2 related proteins
Special feature of COVID-19 in FMODB: Fragment molecular orbital calculations and interaction energy analysis of SARS-CoV-2 related proteins Open
SARS-CoV-2 is the causative agent of coronavirus, globally known as COVID-19. There are ongoing researches to develop effective therapeutics and vaccines against COVID-19 using various methods. We currently conduct research based on the fr…
View article: Regulation of Collective Metastasis by Nanolumenal Signaling
Regulation of Collective Metastasis by Nanolumenal Signaling Open
View article: Pluripotent stem cell-derived skeletal muscle fibers preferentially express myosin heavy-chain isoforms associated with slow and oxidative muscles
Pluripotent stem cell-derived skeletal muscle fibers preferentially express myosin heavy-chain isoforms associated with slow and oxidative muscles Open
Background Skeletal muscle function is essential for health, and it depends on the proper activity of myofibers and their innervating motor neurons. Each adult muscle is composed of different types of myofibers with distinct contractile an…
View article: Transplantation studies reveal internuclear transfer of toxic RNA in engrafted muscles of myotonic dystrophy 1 mice
Transplantation studies reveal internuclear transfer of toxic RNA in engrafted muscles of myotonic dystrophy 1 mice Open
View article: Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment
Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment Open
Optimal cell-based therapies for the treatment of muscle degenerative disorders should not only regenerate fibers but provide a quiescent satellite cell pool ensuring long-term maintenance and regeneration. Conditional expression of Pax3/P…
View article: Generation of skeletal myogenic progenitors from human pluripotent stem cells using non-viral delivery of minicircle DNA
Generation of skeletal myogenic progenitors from human pluripotent stem cells using non-viral delivery of minicircle DNA Open
View article: PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic Progenitors
PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic Progenitors Open
Pluripotent stem (PS) cell-derived cell types hold promise for treating degenerative diseases. However, PS cell differentiation is intrinsically heterogeneous therefore clinical translation requires development of practical methods for iso…
View article: Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models
Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models Open
Key Points Leukemia-forming activity is enriched in endoglin-expressing AML and B-ALL blasts using a mouse xenograft model. Inhibition of endoglin function with TRC105 reduces leukemia development and progression.
View article: Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1
Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1 Open
Significance αTAT1 is an enzyme that acetylates microtubules inside of cells, and acetylation is an important posttranslational microtubule modification. However, microtubules are long tubes, and the acetylation site for αTAT1 is on the in…
View article: Targeted mutagenesis of intergenic regions in the <scp><i>N</i></scp><i>eisseria gonorrhoeae</i> gonococcal genetic island reveals multiple regulatory mechanisms controlling type <scp>IV</scp> secretion
Targeted mutagenesis of intergenic regions in the <span><i>N</i></span><i>eisseria gonorrhoeae</i> gonococcal genetic island reveals multiple regulatory mechanisms controlling type <span>IV</span> secretion Open
Summary Gonococci secrete chromosomal DNA into the extracellular environment using a type IV secretion system ( T4SS ). The secreted DNA acts in natural transformation and initiates biofilm development. Although the DNA and its effects are…