Amie K. Waller
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View article: Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche
Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche Open
The safety, quality and supply of donor-derived platelet units intended for transfusion have improved over the past decades but significant problems still remain. In vitroderived platelets offer a possible alternative but up-scaling produc…
View article: Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…
View article: Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination
Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…
View article: Author response: Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination
Author response: Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…
View article: Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination
Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyeli…
View article: Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…
View article: Reviewer #2 (Public Review): Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination
Reviewer #2 (Public Review): Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyeli…
View article: Reviewer #1 (Public Review): Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination
Reviewer #1 (Public Review): Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function and remyelination is important to optimise the development regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyeli…
View article: Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination
Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination Open
Revealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remye…
View article: Highly efficient platelet generation in lung vasculature reproduced by microfluidics
Highly efficient platelet generation in lung vasculature reproduced by microfluidics Open
Platelets, small hemostatic blood cells, are derived from megakaryocytes (MKs). It is accepted that both bone marrow (BM) and lung are principal sites of thrombogenesis although underlying mechanisms remain unclear. Outside the body, howev…
View article: Activation of Human Platelets by Staphylococcus aureus Secreted Protease Staphopain A
Activation of Human Platelets by Staphylococcus aureus Secreted Protease Staphopain A Open
Infection by Staphylococcus aureus is the leading cause of infective endocarditis (IE). Activation of platelets by this pathogen results in their aggregation and thrombus formation which are considered to be important steps in the developm…
View article: STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion
STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion Open
Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal downstream mediator of interferon (IFN) signaling and is required…
View article: CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia
CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia Open
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count…
View article: Platelet generation from circulating megakaryocytes is triggered in the lung vasculature
Platelet generation from circulating megakaryocytes is triggered in the lung vasculature Open
Platelets are small anucleate blood cells1,2 with critical roles in haemostasis, thrombosis, inflammation, vascularization, innate immunity and tissue regeneration3,4. In vitro-derived platelets, as an alternative to native platelets, are …
View article: Platelet generation from circulating megakaryocytes is triggered in the lung vasculature
Platelet generation from circulating megakaryocytes is triggered in the lung vasculature Open
Platelets, small hemostatic blood cells, are derived from megakaryocytes, although the generation process is not clear. Only small numbers of platelets have been produced in systems outside the body, where bone marrow and lung are proposed…
View article: Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors
Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors Open
The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address severa…
View article: In vitro-derived platelets: the challenges we will have to face to assess quality and safety
In vitro-derived platelets: the challenges we will have to face to assess quality and safety Open
Platelet transfusions are given to patients in hospital who have a low blood platelet count (thrombocytopenia) either because of major bleeding (following trauma or surgery) or because the bone marrow production of platelets is impaired of…
View article: Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging Open
Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. However, the role of HSC-intrinsic and -extrinsic aging mechanisms remains debated. Megakaryocytes promote quiescence o…
View article: Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion
Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion Open
BACKGROUND: Neonatal haemorrhaging is often co-observed with thrombocytopenia; however, no evidence of a causal relationship with low platelet count has been reported. Regardless, the administration of a platelet transfusion is often based…
View article: Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms
Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms Open
Background: BM HSC accumulate during aging but are functionally impaired; however, it remains debated whether this aging results from HSC-intrinsic and/or -extrinsic mechanisms. Myeloid malignancies are more frequent in the elderly, but wh…