Amin Doostmohammadi
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View article: Identifying non-equilibrium fluctuations in Intracellular Motion Using Recurrent Neural Networks
Identifying non-equilibrium fluctuations in Intracellular Motion Using Recurrent Neural Networks Open
Distinguishing active from passive dynamics is a fundamental challenge in understanding the motion of living cells and other active matter systems. Here, we introduce a framework that combines physical modeling, analytical theory, and mach…
View article: Packing-Driven Mechanotransduction: local crowding overrides adhesion and stiffness cues for YAP Activation in Cellular Collectives
Packing-Driven Mechanotransduction: local crowding overrides adhesion and stiffness cues for YAP Activation in Cellular Collectives Open
The regulation of mechanotransduction is crucial for various cellular processes, including stem cell differentiation, wound healing, and cancer progression. While the activation of mechanotransduction has been extensively studied in single…
View article: A spectrum of p-atic symmetries and defects in confluent epithelia
A spectrum of p-atic symmetries and defects in confluent epithelia Open
Topological defects provide a unifying language to describe how orientational order breaks down in active and living matter. Considering cells as elongated particles confluent, epithelial tissues can be interpreted as nematic fields and it…
View article: Strings and topological defects govern ordering kinetics in endothelial cell layers
Strings and topological defects govern ordering kinetics in endothelial cell layers Open
Many physiological processes, such as the shear flow alignment of endothelial cells in the vasculature, depend on the transition of cell layers between disordered and ordered phases. Here we demonstrate that such a transition is driven by …
View article: Anti-hyperuniform critical states of active topological defects
Anti-hyperuniform critical states of active topological defects Open
Topological defects are fundamental to the collective dynamics of non-equilibrium systems and in active matter, mediating spontaneous flows, dynamic self-organization, and emergent pattern formation. Here, we reveal critical states in acti…
View article: Self-propulsive active nematics
Self-propulsive active nematics Open
Increasing evidence suggests that active matter exhibits instances of mixed symmetry that cannot be fully described by either polar or nematic formalism. Here, we introduce a minimal model that integrates self-propulsion into the active ne…
View article: Author response: Quantifying the shape of cells - from Minkowski tensors to p-atic orders
Author response: Quantifying the shape of cells - from Minkowski tensors to p-atic orders Open
View article: Quantifying the shape of cells - from Minkowski tensors to p-atic orders
Quantifying the shape of cells - from Minkowski tensors to p-atic orders Open
P-atic liquid crystal theories offer new perspectives on how cells self-organize and respond to mechanical cues. Understanding and quantifying the underlying orientational orders is therefore essential for unraveling the physical mechanism…
View article: Nematic ordering in active fluids driven by substrate deformations: Mechanisms and patterning regimes
Nematic ordering in active fluids driven by substrate deformations: Mechanisms and patterning regimes Open
The interplay between active matter and its environment is central to understanding emergent behavior in biological and synthetic systems. Here, we show that coupling active nematic flows to small-amplitude deformations of a compliant subs…
View article: The interplay of polar and nematic order in active matter: implications for non-equilibrium physics and biology
The interplay of polar and nematic order in active matter: implications for non-equilibrium physics and biology Open
Active matter has played a pivotal role in advancing understanding of non-equilibrium systems, leading to a fundamental shift in the study of biophysical phenomena. The foundation of active matter research is built on assumptions regarding…
View article: Quantifying the shape of cells - from Minkowski tensors to p-atic order
Quantifying the shape of cells - from Minkowski tensors to p-atic order Open
P-atic liquid crystal theories offer new perspectives on how cells self-organize and respond to mechanical cues. Understanding and quantifying the underlying orientational orders is therefore essential for unraveling the physical mechanism…
View article: Author response: Quantifying the shape of cells - from Minkowski tensors to p-atic order
Author response: Quantifying the shape of cells - from Minkowski tensors to p-atic order Open
View article: Quantifying the shape of cells, from Minkowski tensors to p-atic orders
Quantifying the shape of cells, from Minkowski tensors to p-atic orders Open
P -atic liquid crystal theories offer new perspectives on how cells self-organize and respond to mechanical cues. Understanding and quantifying the underlying orientational orders is, therefore, essential for unraveling the physical mechan…
View article: How intercellular forces regulate cell competition
How intercellular forces regulate cell competition Open
View article: Force transmission is a master regulator of mechanical cell competition
Force transmission is a master regulator of mechanical cell competition Open
View article: Evidence of universal conformal invariance in living biological matter
Evidence of universal conformal invariance in living biological matter Open
View article: Phase diagram, confining strings, and a new universality class in nematopolar matter
Phase diagram, confining strings, and a new universality class in nematopolar matter Open
We study a minimal model of a system with coexisting nematic and polar orientational orders, where one field tends to order and the other prefers isotropy. For strong coupling, the ordered field aligns the isotropic one, locking their orie…
View article: Quantifying the shape of cells - from Minkowski tensors to p-atic orders
Quantifying the shape of cells - from Minkowski tensors to p-atic orders Open
P -atic liquid crystal theories offer new perspectives on how cells self-organize and respond to mechanical cues. Understanding and quantifying the underlying orientational orders is therefore essential for unraveling the physical mechanis…
View article: Mechanical stresses govern myoblast fusion and myotube growth
Mechanical stresses govern myoblast fusion and myotube growth Open
Myoblast fusion into myotubes is critical for muscle formation, growth and repair. While the cellular and molecular mechanisms regulating myoblast fusion are increasingly understood, the role of biomechanics in this process remains largely…
View article: Topological Excitations govern Ordering Kinetics in Endothelial Cell Layers
Topological Excitations govern Ordering Kinetics in Endothelial Cell Layers Open
Many physiological processes, such as the shear flow alignment of endothelial cells in the vasculature, depend on the transition of cell layers between disordered and ordered phases. Here, we demonstrate that such a transition is driven by…
View article: Transport of topological defects in a biphasic mixture of active and passive nematic fluids
Transport of topological defects in a biphasic mixture of active and passive nematic fluids Open
Collectively moving cellular systems often contain a proportion of dead cells or non-motile genotypes. When mixed, nematically aligning motile and non-motile agents are known to segregate spontaneously. However, the role that topological d…
View article: Beyond Dipolar Activity: Quadrupolar Stress Drives Collapse of Nematic Order on Frictional Substrates
Beyond Dipolar Activity: Quadrupolar Stress Drives Collapse of Nematic Order on Frictional Substrates Open
The field of active nematics has traditionally employed descriptions based on dipolar activity, with interactions that align along a single axis. However, it has been theoretically predicted that interactions with a substrate, prevalent in…
View article: Transport of topological defects in a biphasic mixture of active and passive nematic fluids
Transport of topological defects in a biphasic mixture of active and passive nematic fluids Open
Collectively moving cellular systems often contain a proportion of dead cells or non-motile genotypes. When mixed, nematically aligning motile and non-motile agents are known to segregate spontaneously. However, the role that topological d…
View article: Short-range correlation of stress chains near solid-to-liquid transition in active monolayers
Short-range correlation of stress chains near solid-to-liquid transition in active monolayers Open
Using a three-dimensional model of cell monolayers, we study the spatial organization of active stress chains as the monolayer transitions from a solid to a liquid state. The critical exponents that characterize this transition map the iso…
View article: Active particles knead three-dimensional gels into open crumbs
Active particles knead three-dimensional gels into open crumbs Open
Colloidal gels are prime examples of functional materials exhibiting disordered, amorphous, yet meta-stable forms. They maintain stability through short-range attractive forces and their material properties are tunable by external forces. …
View article: Evidence of robust, universal conformal invariance in living biological matter
Evidence of robust, universal conformal invariance in living biological matter Open
Collective cellular movement plays a crucial role in many processes fundamental to health, including development, reproduction, infection, wound healing, and cancer. The emergent dynamics that arise in these systems are typically thought t…
View article: Emergent collective alignment gives competitive advantage to longer cells during range expansion
Emergent collective alignment gives competitive advantage to longer cells during range expansion Open
Bacteria’s competition for nutrients and territory drives biofilm evolution (1 –4). The factors determining the outcome of competition among diverse bacterial species have a broad impact on a wide range of pathological (5), environmental (…
View article: Emergent collective alignment gives competitive advantage to longer cells during range expansion
Emergent collective alignment gives competitive advantage to longer cells during range expansion Open
Bacterial competition shapes community architecture, yet a universally conserved determinant remains elusive. We show that cell aspect ratio –a simple morphological feature– confers a competitive advantage. Using growth-based range expansi…
View article: Spontaneous self-constraint in active nematic flows
Spontaneous self-constraint in active nematic flows Open
Active processes drive biological dynamics across various scales and include subcellular cytoskeletal remodelling, tissue development in embryogenesis and the population-level expansion of bacterial colonies. In each of these, biological f…
View article: Elasticity tunes mechanical stress localization around active topological defects
Elasticity tunes mechanical stress localization around active topological defects Open
Topological defects play diverse roles in biology. We find that tuning the passive elasticity substantially changes the intensity and extent of stresses, and in active systems can invert the defect motion and stress pattern.