Amin T. Turki
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View article: Adaptation, refinement and clinical correlation of a pharmacokinetics model for patients receiving anti-T-lymphocyte globulin as part of their conditioning regimen: Advances towards individualized dosing.
Adaptation, refinement and clinical correlation of a pharmacokinetics model for patients receiving anti-T-lymphocyte globulin as part of their conditioning regimen: Advances towards individualized dosing. Open
Introduction Despite the advantages of including anti-thymocyte globulin (ATG) or anti-T-lymphocyte globulin (ATLG) in the conditioning regimen for graft-versus-host disease prophylaxis (GVHD, Admiraal et al. Blood 2016, Turki et al. Am. J…
View article: Validation of measurable residual disease as a surrogate endpoint in acute myeloid leukemia: A HARMONY Alliance study of European randomized trials
Validation of measurable residual disease as a surrogate endpoint in acute myeloid leukemia: A HARMONY Alliance study of European randomized trials Open
Introduction: Measurable residual disease (MRD) prior to consolidation therapy is a strong prognostic biomarker for relapse and long-term survival in acute myeloid leukemia (AML). Beyond its prognostic role, MRD is increasingly used to gui…
View article: Activity of Quercetin Derivatives as Antibacterial, Antioxidant and Anticancer Agents
Activity of Quercetin Derivatives as Antibacterial, Antioxidant and Anticancer Agents Open
View article: Automated ICD-O-3 Coding of Real-World Pathology Reports Using Self-Hosted Large Language Models
Automated ICD-O-3 Coding of Real-World Pathology Reports Using Self-Hosted Large Language Models Open
While large language models (LLMs) have shown promise in medical text processing, their real-world application in self-hosted clinical settings remains underexplored. Here, we evaluated five state-of-the-art self-hosted LLMs for automated …
View article: Unicorns transforming the practice of urology: value creation and allocation in the digital age
Unicorns transforming the practice of urology: value creation and allocation in the digital age Open
View article: Model‐Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation
Model‐Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation Open
Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ and transplantation‐related factors, associated with poor prognoses for poor graft function (PGF) an…
View article: Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma
Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma Open
The treatment landscape for lymphoma and multiple myeloma, which disproportionally affect older adults, has been transformed by the advent of T cell-mediated immunotherapies, including immune checkpoint inhibition, T cell-engaging bispecif…
View article: The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin
The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin Open
Acquired resistance to platinum-derived cytostatics poses major challenges in ovarian carcinoma therapy. In this work, we show a shift in the epithelial-mesenchymal transition (EMT) process towards an “ectodermal” conversion of ovarian car…
View article: Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance Open
Since 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcome of patients with acute myeloid leukemia (AML). However, even before these innovations outcomes with intensive chemotherapy hav…
View article: Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study
Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study Open
Balanced rearrangements involving the KMT2A gene ( KMT2A r) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the prognostic impact of different fusion partners. Moreover, prognos…
View article: Advances in decision support for diagnosis and early management of acute leukaemia
Advances in decision support for diagnosis and early management of acute leukaemia Open
View article: Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in onco-hematology
Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in onco-hematology Open
Onco-hematological studies are increasingly adopting statistical mixture models to support the advancement of the genomically-driven classification systems for blood cancer. Targeting enhanced patients stratification based on the sole role…
View article: A dynamic time‐to‐event model for prediction of acute graft‐versus‐host disease in patients after allogeneic hematopoietic stem cell transplantation
A dynamic time‐to‐event model for prediction of acute graft‐versus‐host disease in patients after allogeneic hematopoietic stem cell transplantation Open
Background Acute graft‐versus‐host disease (aGvHD) is a major cause of death for patients following allogeneic hematopoietic stem cell transplantation (HSCT). Effective management of moderate to severe aGvHD remains challenging despite rec…
View article: Data-driven grading of acute graft-versus-host disease
Data-driven grading of acute graft-versus-host disease Open
View article: Real-world evaluation of UK high hyperdiploidy profile using a large cohort of patients provided by HARMONY data platform
Real-world evaluation of UK high hyperdiploidy profile using a large cohort of patients provided by HARMONY data platform Open
View article: Protocol for a pilot trial to implement diagnostics for clonal hematopoiesis of indeterminate potential into routine clinical care of older patients with breast cancer
Protocol for a pilot trial to implement diagnostics for clonal hematopoiesis of indeterminate potential into routine clinical care of older patients with breast cancer Open
Background: Clonal hematopoiesis of indeterminate potential (CHIP) refers to the presence of a hematopoietic clone with a common leukemia driver mutation without diagnosis of an underlying hematopoietic disease. The prevalence of CHIP is i…
View article: P362: OUTCOMES IN PATIENTS WITH RELAPSED OR REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA RECEIVING HEMATOPOIETIC CELL TRANSPLANTATION USING REAL-WORLD DATA FROM HARMONY
P362: OUTCOMES IN PATIENTS WITH RELAPSED OR REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA RECEIVING HEMATOPOIETIC CELL TRANSPLANTATION USING REAL-WORLD DATA FROM HARMONY Open
Background: Hematopoietic cell transplantation (HSCT) is a standard consolidation treatment for patients (pts) with relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL). However, predicting post-HSCT survival and related outcome…
View article: Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in Onco-Hematology
Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in Onco-Hematology Open
Onco-hematological studies are increasingly adopting statistical mixture models to support the advancement of the genetically-driven classification systems for blood cancer. Targeting enhanced patients stratification based on the sole role…
View article: Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy
Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy Open
Introduction Anti-T-lymphocyte globulin (ATG) or post-transplant cyclophosphamide (PTCy) prevent graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), yet individual patients benefit differentially. Methods Given…
View article: Impact of chronic graft-versus-host-disease on intensive care outcome in allogeneic hematopoietic stem cell recipients
Impact of chronic graft-versus-host-disease on intensive care outcome in allogeneic hematopoietic stem cell recipients Open
Chronic graft-vs-host-disease (cGvHD) is the most relevant long-term complication after allogeneic stem cell transplantation (HSCT) with major impact on non-relapse mortality, but data on intensive care unit (ICU) outcome are missing. In t…
View article: Time‐dependent prediction of mortality and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation using machine learning
Time‐dependent prediction of mortality and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation using machine learning Open
Allogeneic hematopoietic cell transplantation (HCT) effectively treats high‐risk hematologic diseases but can entail HCT‐specific complications, which may be minimized by appropriate patient management, supported by accurate, individual ri…
View article: Early report on the severity of <scp>COVID</scp>‐19 in hematologic patients infected with the <scp>SARS‐CoV2</scp> omicron variant
Early report on the severity of <span>COVID</span>‐19 in hematologic patients infected with the <span>SARS‐CoV2</span> omicron variant Open
Introduction Patients with hematologic disease are at high risk of morbidity and mortality from COVID‐19 due to disease‐inherent and therapy‐related immunodeficiency. Whether infection with the SARS‐CoV2 omicron variant leads to attenuated…
View article: Combined Analysis of Early CD4+ T Cell Counts and CMV Serostatus May Improve CMV Risk Assessment after Allogeneic Hematopoietic Cell Transplantation
Combined Analysis of Early CD4+ T Cell Counts and CMV Serostatus May Improve CMV Risk Assessment after Allogeneic Hematopoietic Cell Transplantation Open
The incidence and severity of viral complications after cellular therapy are highly variable. Recent publications describe relevant interactions between the human Cytomegalovirus (CMV) and host immunity in recipients of allogeneic hematopo…
View article: Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG
Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG Open
Cytomegalovirus (CMV) reactivation is a frequent complication after allogeneic hematopoietic cell transplantation (HCT), whose impact on clinical outcome, in particular on leukemic relapse, is controversial. We retrospectively analyzed 687…
View article: Time-dependent prediction of mortality and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation using machine learning
Time-dependent prediction of mortality and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation using machine learning Open
Allogeneic hematopoietic cell transplantation (HCT) effectively treats high-risk hematologic diseases but can entail HCT-specific complications, which may be minimized by appropriate patient management, supported by accurate, individual ri…
View article: Real-World Efficacy of Docetaxel Plus Nintedanib After Chemo-Immunotherapy Failure in Advanced Pulmonary Adenocarcinoma
Real-World Efficacy of Docetaxel Plus Nintedanib After Chemo-Immunotherapy Failure in Advanced Pulmonary Adenocarcinoma Open
Aim: This real-world analysis evaluated docetaxel plus nintedanib in patients with advanced pulmonary adenocarcinoma after chemotherapy and immune checkpoint inhibitor failure, for whom treatment options are limited. Methods:…
View article: A bi‐centric experience of extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) for acute hypercapnic respiratory failure following allogeneic hematopoietic stem cell transplantation
A bi‐centric experience of extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) for acute hypercapnic respiratory failure following allogeneic hematopoietic stem cell transplantation Open
Acute respiratory failure (ARF) is the main reason for ICU admission following allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal CO 2 removal (ECCO 2 R) can be used as an adjunct to mechanical ventilation in patient…
View article: Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution
Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution Open
Even in the era of PCR‐based monitoring, prophylaxis, and preemptive therapy, Cytomegalovirus (CMV) viremia remains a relevant cause of non‐relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, studies…
View article: Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM
Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM Open
In hematopoietic cell transplantation (HCT), permissive HLA-DPB1 mismatches between patients and their unrelated donors are associated with improved outcomes compared with nonpermissive mismatches, but the underlying mechanism is incomplet…
View article: 1374P Docetaxel/nindetanib as efficient treatment option after failure of immune checkpoint inhibition: Real-world evidence
1374P Docetaxel/nindetanib as efficient treatment option after failure of immune checkpoint inhibition: Real-world evidence Open