Amin Tamadon
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View article: Mercury exposure, epigenetic modifications, and genetic susceptibility: insights from molecular docking and population analysis
Mercury exposure, epigenetic modifications, and genetic susceptibility: insights from molecular docking and population analysis Open
Introduction Mercury (Hg) is a major environmental contaminant and public health concern, particularly in industrial regions where metallurgical activities contribute to elevated Hg emissions. Genetic factors influencing susceptibility to …
View article: Glycocalyx and Endothelial Biomarkers as Prognostic Indicators in Sepsis: A Systematic Review and Meta‐Analysis
Glycocalyx and Endothelial Biomarkers as Prognostic Indicators in Sepsis: A Systematic Review and Meta‐Analysis Open
Sepsis‐induced endothelial dysfunction, marked by degradation of the endothelial glycocalyx and activation of endothelial cells, plays a pivotal role in the progression to organ failure and mortality. Biomarkers reflecting glycocalyx damag…
View article: Socioeconomic and demographic factors influencing dietary patterns in Aktobe: a sample of Kazakhstan’s dietary culture
Socioeconomic and demographic factors influencing dietary patterns in Aktobe: a sample of Kazakhstan’s dietary culture Open
Background Dietary patterns are shaped by a combination of cultural traditions, socioeconomic conditions, and demographic characteristics. In Kazakhstan, rapid economic growth, urbanization, and globalization are influencing food consumpti…
View article: Traditional Chinese Medicine for childhood obesity: an umbrella review of systematic reviews and meta-analyses
Traditional Chinese Medicine for childhood obesity: an umbrella review of systematic reviews and meta-analyses Open
Background Childhood obesity is a major global public health concern associated with adverse cardiometabolic outcomes and long-term health risks. While conventional treatments such as diet, exercise, and behavioral therapy remain the corne…
View article: The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis
The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis Open
Background The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been linked to various diabetic complications. However, its association with diabetic retinopathy (DR) remains inconsistent. We conducted a syst…
View article: Bibliometric Analysis of Kidney Transplantation-related Cell Therapy: Platelet-rich Plasma, Mesenchymal Stromal/Stem Cells, and Hematopoietic Stem Cells
Bibliometric Analysis of Kidney Transplantation-related Cell Therapy: Platelet-rich Plasma, Mesenchymal Stromal/Stem Cells, and Hematopoietic Stem Cells Open
View article: Distinct gut microbial species, but not phylum-to-genus composition, associate with insulin resistance: a unique perspective from the Kazakh population
Distinct gut microbial species, but not phylum-to-genus composition, associate with insulin resistance: a unique perspective from the Kazakh population Open
Objectives Links between gut microbiota and insulin resistance (IR) vary across populations. We profiled the fecal microbiota of Kazakh adults to test whether community composition associates with IR at broad (phylum → genus) and species l…
View article: Umbrella review of mesenchymal stem cell-derived extracellular vesicles in preclinical models: therapeutic efficacy across diverse conditions
Umbrella review of mesenchymal stem cell-derived extracellular vesicles in preclinical models: therapeutic efficacy across diverse conditions Open
Background Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising cell-free therapeutic strategy for various diseases due to their anti-inflammatory, anti-apoptotic, and regenerative properties. Numerous…
View article: Prognostic biomarkers for predicting decompensation in alcoholic and non-alcoholic patients with compensated cirrhosis: a systematic review and meta-analysis
Prognostic biomarkers for predicting decompensation in alcoholic and non-alcoholic patients with compensated cirrhosis: a systematic review and meta-analysis Open
Background Hepatic decompensation is a critical turning point in the progression of compensated cirrhosis, with distinct pathophysiological trajectories in alcoholic and non-alcoholic etiologies. This systematic review and meta-analysis ev…
View article: Insights into research trends on recurrent laryngeal nerve damage in thyroid surgery (1974–2024): a bibliometric review
Insights into research trends on recurrent laryngeal nerve damage in thyroid surgery (1974–2024): a bibliometric review Open
This bibliometric analysis underscores the increasing global research focus on RLN injury in thyroidectomy, highlighting the need for enhanced surgical techniques, international collaboration, and standardized practices to improve patient …
View article: Autologous and allogeneic mesenchymal stem cell-based therapies for diabetes mellitus: A systematic review and meta-analysis
Autologous and allogeneic mesenchymal stem cell-based therapies for diabetes mellitus: A systematic review and meta-analysis Open
BACKGROUND Diabetes mellitus (DM) is a global health concern, characterized by insulin resistance and β-cell dysfunction. Traditional treatments often fail to address underlying mechanisms, necessitating alternative therapies. Mesenchymal …
View article: Chemical characterization, antibacterial, and antiproliferative bioactivities of natural melanin-based quantum dots from Aplysia dactylomela sea hare ink
Chemical characterization, antibacterial, and antiproliferative bioactivities of natural melanin-based quantum dots from Aplysia dactylomela sea hare ink Open
This study focused on the extraction, isolation, and characterization of natural melanin-based quantum dots (NMQDs) derived from the ink of the sea hare Aplysia dactylomela , with an evaluation of their antibacterial and anticancer propert…
View article: Methodological Approaches for Economic Comparison of Mesenchymal Stem Cell and Exosome-based Therapies with Conventional Endodontic Treatments in Regenerative Endodontics
Methodological Approaches for Economic Comparison of Mesenchymal Stem Cell and Exosome-based Therapies with Conventional Endodontic Treatments in Regenerative Endodontics Open
Regenerative endodontics, particularly through mesenchymal stromal cell (MSC)- based and exosome-based therapies, presents innovative alternatives to traditional endodontic treatments. However, the economic feasibility of integrating these…
View article: Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice.
Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice. Open
Our findings indicate that both BMCM enriched with EVs and the administration of AT-MSCs and BM-MSCs effectively induced spermatogenesis in mice with busulfan-induced azoospermia. Specifically, BM-MSC therapy exhibited superior outcomes co…
View article: Induction of Apoptosis by Ethanol, Methanol, and Ethyl Acetate Extracts from <i>Cyperus Rotundus'</i> Leaf on <i>In Vitro</i> Human Ovarian, Cervix, and Breast Cancer Cell Lines.
Induction of Apoptosis by Ethanol, Methanol, and Ethyl Acetate Extracts from <i>Cyperus Rotundus'</i> Leaf on <i>In Vitro</i> Human Ovarian, Cervix, and Breast Cancer Cell Lines. Open
Hydroalcoholic extracts from C. rotundus' leaf may enhance the apoptosis of cancer cells by modulating the transcription, translation, and post-translation of proteins, with minimal impact on the growth and survival of non-cancerous…
View article: Uncovering Novel Anti-Lung Cancer Compounds: Insights from Marine Sponge-Derived Agents: A Bibliometric Review.
Uncovering Novel Anti-Lung Cancer Compounds: Insights from Marine Sponge-Derived Agents: A Bibliometric Review. Open
This study highlights the potential of alkaloids and sesquiterpenes derived from marine sponges as promising anti-lung cancer agents, emphasizing the need for further in vitro, in vivo, and clinical investigations to validate…
View article: Mouse brain lymphatic vessels
Mouse brain lymphatic vessels Open
The lymphatic system plays a vital role in immune function and waste removal, yet its involvement in the brain has remained largely unexplored. This study provides compelling evidence of lymphatic vessels in the mouse brain, specifically i…
View article: Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches
Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches Open
The inability to get or sustain an erection strong enough for fulfilling sexual performance is the hallmark of the common disorder known as erectile dysfunction (ED). It mostly affects a significant percentage of men worldwide, particularl…
View article: Comparison of Exosome Isolation Techniques for Clinical Applications
Comparison of Exosome Isolation Techniques for Clinical Applications Open
Exosomes are extracellular vesicles with significant potential in clinical applications, particularly in diagnostics and therapeutics. Effective exosome isolation is critical to ensuring their functionality and integrity, especially for cl…
View article: Polycystic Ovary Syndrome Herbal Treatments and Medicinal Plants: A Comprehensive Review
Polycystic Ovary Syndrome Herbal Treatments and Medicinal Plants: A Comprehensive Review Open
Polycystic ovary syndrome (PCOS) represents one of the most common endocrine disorders affecting women of reproductive age, serving as a major contributor to infertility on a global scale, with an estimated prevalence varying from 6 to 20%…
View article: Therapeutic Effects of <i>Cynodon dactylon (C. dactylon)</i> against Polycystic Ovary Syndrome Induced by Letrozole in Adult Rats: Ovarian and Uterine Aspects.
Therapeutic Effects of <i>Cynodon dactylon (C. dactylon)</i> against Polycystic Ovary Syndrome Induced by Letrozole in Adult Rats: Ovarian and Uterine Aspects. Open
C. dactylon extract could display positive effects on both the ovary and uterus of letrozole-induced PCOS rats. Therefore, C. dactylon had therapeutic effects on the ovary and uterus of PCOS-induced rat models.
View article: A Cross-Sectional Analysis of Maternal Cardiac Autonomic Function in Kazakh Pregnant Women with Gestational Diabetes
A Cross-Sectional Analysis of Maternal Cardiac Autonomic Function in Kazakh Pregnant Women with Gestational Diabetes Open
The nomogram developed in this study may prove useful for clinicians and patients in making informed clinical decisions and assessing outcomes. Notably, no significant differences in HRV were observed between women with uncomplicated pregn…
View article: Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms
Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms Open
Ulcerative colitis is a type of inflammatory bowel disease (IBD) that has risen around the world in recent years. Diet, lifestyle, genetics, stress, are the risk factors of ulcerative colitis. Indeed, oxidative stress, impairment of the in…
View article: Mapping the Landscape of Mesenchymal Stem Cell‐Derived Extracellular Vesicles: From Bench to Bedside
Mapping the Landscape of Mesenchymal Stem Cell‐Derived Extracellular Vesicles: From Bench to Bedside Open
Mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs), including exosomes, have garnered significant attention for their therapeutic potential in regenerative medicine and inflammatory disease management. This bibliometric analy…
View article: The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report.
The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report. Open
The dental pulp is essential for tooth health and sensory function. However, conventional treatments for infected or necrotic pulp, such as root canal therapy, frequently result in tooth loss and increased fracture risk. Regenerative endod…
View article: Transitioning the Journal of Infertility and Reproductive Biology (JIRB) to New Horizons
Transitioning the Journal of Infertility and Reproductive Biology (JIRB) to New Horizons Open
The Journal of Infertility and Reproductive Biology ( JIRB) is a prestigious quarterly, peer-reviewed, open-access journal dedicated to advancing research in the fields of infertility and reproductive sciences. This editorial announces the…
View article: Ligand-based Exosome Affinity Purification (LEAP) Column Chromatography: A Tool for Clinical Applications
Ligand-based Exosome Affinity Purification (LEAP) Column Chromatography: A Tool for Clinical Applications Open
Exosomes are nano-sized extracellular vesicles that play essential roles in intercellular communication, carrying biomolecules such as proteins, lipids, and RNAs that can influence physiological and pathological processes. The isolation of…
View article: Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats
Impact of alcoholic extract from sea cucumber (Holothuria parva) on letrozole–induced polycystic ovary syndrome in adult female rats Open
Objective: To explore the potential therapeutic impact of an alcoholic extract derived from the sea cucumber ( Holothuria parva ) on letrozole-induced polycystic ovary syndrome (PCOS) in adult female Sprague-Dawley rats. Methods: Sixteen f…
View article: Different storage and freezing protocols for extracellular vesicles: a systematic review
Different storage and freezing protocols for extracellular vesicles: a systematic review Open
Data emphasize the critical need for precise storage protocols for EVs to ensure reproducible research outcomes and clinical applications. Further studies using reliable methods are necessary to create specific guidelines for improving the…
View article: The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function
The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function Open
The gut-brain-metabolic axis has emerged as a critical area of research, highlighting the intricate connections between the gut microbiome, metabolic processes, and cognitive function. This review article delves into the complex interplay …