Amina Bedrat
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View article: Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity
Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity Open
Background General anesthetics have been shown to cause acute pathological changes in the developing brain, including neuronal cell death. These effects contribute to long-term cognitive and behavioral impairments observed in animal models…
View article: Monocytes in type 1 diabetes families exhibit high cytolytic activity and subset abundances that correlate with clinical progression
Monocytes in type 1 diabetes families exhibit high cytolytic activity and subset abundances that correlate with clinical progression Open
Monocytes are immune regulators implicated in the pathogenesis of type 1 diabetes (T1D), an autoimmune disease that targets insulin-producing pancreatic β cells. We determined that monocytes of recent onset (RO) T1D patients and their heal…
View article: UGDR: a generic pipeline to detect recombined regions in polyploid and complex hybrid yeast genomes
UGDR: a generic pipeline to detect recombined regions in polyploid and complex hybrid yeast genomes Open
View article: Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection Open
G-quadruplexes (G4s) are four-stranded nucleic acid structures formed by the stacking of G-tetrads. Here we investigated their formation and function during HIV-1 infection. Using bioinformatics and biophysics analyses we first searched fo…
View article: Airway Epithelial Cells Drive Airway Smooth Muscle Cell Phenotype Switching to the Proliferative and Pro-inflammatory Phenotype
Airway Epithelial Cells Drive Airway Smooth Muscle Cell Phenotype Switching to the Proliferative and Pro-inflammatory Phenotype Open
The increased mass of airway smooth muscle (ASM) in the airways of asthmatic patients may contribute to the pathology of this disease by increasing the capacity for airway narrowing. Evidence for the airway epithelium as a participant in A…
View article: Recombination in a sterile polyploid hybrid yeast upon meiotic Return-To-Growth
Recombination in a sterile polyploid hybrid yeast upon meiotic Return-To-Growth Open
The sustainable future of food industry and consumer demands meet the need to generate out-performing new yeast variants. This is addressed by using the natural yeast diversity and breeding via sexual reproduction but the recovery of recom…
View article: Global RNAseq of ocular cells reveals gene dysregulation in both asymptomatic and with Congenital Zika Syndrome infants exposed prenatally to Zika virus
Global RNAseq of ocular cells reveals gene dysregulation in both asymptomatic and with Congenital Zika Syndrome infants exposed prenatally to Zika virus Open
In 2015, Brazil reported an outbreak identified as Zika virus (ZIKV) infection associated with congenital abnormalities. To date, a total of 86 countries and territories have described evidence of Zika infection and recently the appearance…
View article: Exposure to an Environmentally Relevant Phthalate Mixture During Prostate Development Induces MicroRNA Upregulation and Transcriptome Modulation in Rats
Exposure to an Environmentally Relevant Phthalate Mixture During Prostate Development Induces MicroRNA Upregulation and Transcriptome Modulation in Rats Open
Environmental exposure to phthalates during intrauterine development might increase susceptibility to neoplasms in reproductive organs such as the prostate. Although studies have suggested an increase in prostatic lesions in adult animals …
View article: Author Correction: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand
Author Correction: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand Open
View article: Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum
Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum Open
G-quadruplexes (G4) are non-canonical DNA and/or RNA secondary structures formed in guanine-rich regions. Given their over-representation in specific regions in the genome such as promoters and telomeres, they are likely to play important …
View article: RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand
RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand Open
View article: Re-evaluation of G-quadruplex propensity with G4Hunter
Re-evaluation of G-quadruplex propensity with G4Hunter Open
Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been obtained in seminal studies performed in a variety of organisms. Four-stranded G-quadruplex DNA structures are promising drug targets as these non-cano…
View article: G4-Hunter : a new algorithm for G-quadruplexes prediction’s
G4-Hunter : a new algorithm for G-quadruplexes prediction’s Open
Biologically relevant G4 DNA structures are formed throughout the genome including immunoglobulin switch regions, promoter sequences and telomeric repeats. They can arise when single-stranded G-rich DNA or RNA sequences are exposed during …
View article: G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes
G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes Open
Des séquences compatibles avec la formation de G4 sont présentes au niveau de certaines régions clés du génome telles que les extrémités des chromosomes, mais également les régions de commutation de classe des immunoglobulines, les promote…