Amir Avan
YOU?
Author Swipe
View article: Pan‐cancer analysis and oncogenic implications of <i>MGAM</i> and <i>MGAM2</i>: Toward precision oncology and drug repurposing in colorectal cancer
Pan‐cancer analysis and oncogenic implications of <i>MGAM</i> and <i>MGAM2</i>: Toward precision oncology and drug repurposing in colorectal cancer Open
Cancer remains a major global health challenge, with high prevalence and mortality rates emphasizing the urgent need for innovative treatment strategies. Although precision oncology offers tailored therapies based on genetic profiles, the …
View article: Cytokine and growth factor profiling in patients with the metabolic syndrome – CORRIGENDUM
Cytokine and growth factor profiling in patients with the metabolic syndrome – CORRIGENDUM Open
View article: Author Correction: Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model
Author Correction: Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model Open
View article: 96P Exploiting metabolic reprogramming via targeting novel genetic variant in urocanate hydratase 1 in histidine catabolism as a potential therapeutic approach in the treatment of colorectal cancer
96P Exploiting metabolic reprogramming via targeting novel genetic variant in urocanate hydratase 1 in histidine catabolism as a potential therapeutic approach in the treatment of colorectal cancer Open
View article: 46P Targeting transforming growth factor beta (TGF-β) using pirfenidone: A potential repurposing therapeutic strategy in colorectal cancer
46P Targeting transforming growth factor beta (TGF-β) using pirfenidone: A potential repurposing therapeutic strategy in colorectal cancer Open
View article: Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions
Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions Open
Introduction The therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated. Methods In a rat UA model, Z. jujube was evaluated for its abili…
View article: Correction: Alaei et al. Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models. Cancers 2023, 15, 3939
Correction: Alaei et al. Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models. Cancers 2023, 15, 3939 Open
Error in Figure and Text [...]
View article: Repurposing Artrestan (Sacubitril/Valsartan), unveiling its anti-inflammatory and fibrinolytic properties in ulcerative colitis in rats.
Repurposing Artrestan (Sacubitril/Valsartan), unveiling its anti-inflammatory and fibrinolytic properties in ulcerative colitis in rats. Open
Our findings suggest the therapeutic potential of Artrestan in combination with mesalazine for the treatment of UC, as it modulates clinical symptoms, improves the oxidant-anti-oxidant balance, and reduces pro-inflammatory and pro-fibrotic…
View article: The diagnostic and prognostic value of <i>C1orf174 </i>in colorectal cancer
The diagnostic and prognostic value of <i>C1orf174 </i>in colorectal cancer Open
Introduction: Colorectal cancer (CRC) is among the lethal cancers, indicating the need for the identification of novel biomarkers for the detection of patients in earlier stages. RNA and microRNA sequencing were analyzed using bioinformati…
View article: Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model
Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model Open
View article: The therapeutic potential of red beetroot (<i>Beta vulgaris</i> L.) intake on muscle atrophy in immobilized mouse skeletal muscles
The therapeutic potential of red beetroot (<i>Beta vulgaris</i> L.) intake on muscle atrophy in immobilized mouse skeletal muscles Open
Skeletal muscle atrophy is the reduction in muscle mass and function caused by an imbalance in protein synthesis and degradation. Inflammation has been shown to accelerate protein degradation during periods of muscle inactivity. We investi…
View article: Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma
Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma Open
View article: The evaluation of synergistic effects of combination therapy with sulfasalazine and angiotensin-converting enzyme inhibitor in the treatment of experimental colitis in mice
The evaluation of synergistic effects of combination therapy with sulfasalazine and angiotensin-converting enzyme inhibitor in the treatment of experimental colitis in mice Open
The evaluation of synergistic effects of combination therapy with sulfasalazine and angiotensin-converting enzyme inhibitor in the treatment of experimental colitis in mice
View article: The Therapeutic Application of Hydrogen in Cancer: The Potential andChallenges
The Therapeutic Application of Hydrogen in Cancer: The Potential andChallenges Open
Hydrogen therapy has emerged as a possible approach for both preventing and treating cancer. Cancers are often associated with oxidative stress and chronic inflammation. Hydrogen, with its unique physiological functions and characteristics…
View article: G-Protein Signaling Modulator 2 as a Potential Biomarker in Colorectal Cancer: Integrative Analysis Using Genetic Profiling and Pan-Cancer Studies
G-Protein Signaling Modulator 2 as a Potential Biomarker in Colorectal Cancer: Integrative Analysis Using Genetic Profiling and Pan-Cancer Studies Open
Colorectal cancer (CRC) imposes a significant healthcare burden globally, prompting the quest for innovative biomarkers to enhance diagnostic and therapeutic strategies. This study investigates the G-protein signaling modulator (GPSM) fami…
View article: Genetic Determinants of Response to Statins in Cardiovascular Diseases
Genetic Determinants of Response to Statins in Cardiovascular Diseases Open
Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in…
View article: Microbiome as a biomarker and therapeutic target in pancreatic cancer
Microbiome as a biomarker and therapeutic target in pancreatic cancer Open
View article: Therapeutic potency of curcumin on radiodermatitis: A systematic review.
Therapeutic potency of curcumin on radiodermatitis: A systematic review. Open
Further prospective clinical trials in larger scales are warranted in order to determine the " supplemental form and dose of CUR" for RD prevention and treatment in patients receiving radiotherapy.
View article: Bioinformatics analysis and machine learning approach applied to the identification of novel key genes involved in non-alcoholic fatty liver disease
Bioinformatics analysis and machine learning approach applied to the identification of novel key genes involved in non-alcoholic fatty liver disease Open
View article: Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model
Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model Open
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic poten…
View article: Down regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer
Down regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer Open
View article: Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer Open
View article: The effects of Curcumin and Crocin on the inflammatory phase of thyroid eye disease: a randomized controlled clinical trial
The effects of Curcumin and Crocin on the inflammatory phase of thyroid eye disease: a randomized controlled clinical trial Open
Objective A randomized, triple-blinded study was designed to assess the influences of curcumin and crocin on clinical findings and serologic markers, including IL-6 and TNF-α, of the inflammatory phase of thyroid eye disease (TED). Methods…
View article: #23 Evaluation of the relationship between genetic variants of FCGR3A and ABCB1gene with the risk of cervical cancer
#23 Evaluation of the relationship between genetic variants of FCGR3A and ABCB1gene with the risk of cervical cancer Open
Introduction/Background Cervical cancer (CC) is among the most common diagnosed cancer. Several genetic variants have been identified in ABCB1(RA1128503) region with the risk of developing several cancers. Here we explored the association …
View article: The Prognostic Value of ASPHD1 and ZBTB12 in Colorectal Cancer: A Machine Learning-Based Integrated Bioinformatics Approach
The Prognostic Value of ASPHD1 and ZBTB12 in Colorectal Cancer: A Machine Learning-Based Integrated Bioinformatics Approach Open
Introduction: Colorectal cancer (CRC) is a common cancer associated with poor outcomes, underscoring a need for the identification of novel prognostic and therapeutic targets to improve outcomes. This study aimed to identify genetic varian…
View article: Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models
Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models Open
Cytochrome P450 (CYP450) enzyme has been shown to be expressed in colorectal cancer (CRC) and its dysregulation is linked to tumor progression and a poor prognosis. Here we investigated the therapeutic potential of targeting CYP450 using l…
View article: Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma
Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma Open
Malignant mesothelioma (MM) is a highly aggressive and resistant tumor. The prognostic role of key effectors of glycolytic metabolism in MM prompted our studies on the cytotoxicity of new inhibitors of glucose transporter type 1 (GLUT-1) a…
View article: Data from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells
Data from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of enhancer of Zeste homolog-2 (EZH2), which plays a pivotal role in cancer stem cell (CSC) self-renewal through methylation of histone H3 lysine-27 (H3K27me3). Aga…
View article: Data from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells
Data from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells Open
Pancreatic ductal adenocarcinoma (PDAC) is characterized by overexpression of enhancer of Zeste homolog-2 (EZH2), which plays a pivotal role in cancer stem cell (CSC) self-renewal through methylation of histone H3 lysine-27 (H3K27me3). Aga…
View article: Supplementary Figure 2 from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells
Supplementary Figure 2 from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells Open
PDF file, 117KB, Protein expression of E-cadherin, as detected by immunocytochemistry.