Amir Ghaffari Jolfayi
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View article: Applied machine learning to predict 1-year major adverse cardiovascular events in elderly patients after percutaneous coronary intervention
Applied machine learning to predict 1-year major adverse cardiovascular events in elderly patients after percutaneous coronary intervention Open
View article: Radiomics early assessment of post chemotherapy cardiotoxicity in cancer patients using 2D echocardiography imaging an interpretable machine learning study
Radiomics early assessment of post chemotherapy cardiotoxicity in cancer patients using 2D echocardiography imaging an interpretable machine learning study Open
Cardiotoxicity is the loss of the heart muscle's ability to contract effectively, often due to chemotherapy or radiation therapy. This study uses interpretable machine learning to predict post-chemotherapy cardiotoxicity using radiomics fe…
View article: Pharmacogenomics in cardiac therapy: Personalizing treatment for heart health
Pharmacogenomics in cardiac therapy: Personalizing treatment for heart health Open
Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide. Genetics factors play a significant role in the development of CVDs, which may result from monogenic or polygenic influences. These genetic contributi…
View article: Characterization of cardiac sarcoidosis in Iranian patients using cardiac magnetic resonance and positron emission tomography imaging techniques
Characterization of cardiac sarcoidosis in Iranian patients using cardiac magnetic resonance and positron emission tomography imaging techniques Open
Background: Cardiac involvement in sarcoidosis is associated with high mortality but is often underrecognized due to diagnostic challenges. Advanced imaging modalities like Cardiac Magnetic Resonance (CMR) and Fluorodeoxyglucose Positron E…
View article: Dendritic cell-based vaccines, a promising prospect for ending AIDS and eradication of HIV worldwide: A narrative review on the latest updates
Dendritic cell-based vaccines, a promising prospect for ending AIDS and eradication of HIV worldwide: A narrative review on the latest updates Open
Significant challenges are presented as a result of the ongoing HIV/AIDS pandemic, particularly given the ongoing burden of new infections and the lack of a proven treatment. Among other approaches, vaccinations based on Dendritic Cells (D…
View article: Neurological, functional, and quality of life outcomes following combined mesenchymal stem cell and Schwann cell therapy in spinal cord injury: a 9-year experience
Neurological, functional, and quality of life outcomes following combined mesenchymal stem cell and Schwann cell therapy in spinal cord injury: a 9-year experience Open
This study demonstrates significant neurological, functional, and quality of life improvements following combined cell therapy with autologous MSCs and SCs in patients with complete SCI. Future research should investigate potential synergi…
View article: Epicardial adipose tissue features as a biomarker and therapeutic target in coronary artery disease
Epicardial adipose tissue features as a biomarker and therapeutic target in coronary artery disease Open
View article: Invasive versus conservative strategies for non-ST-elevation acute coronary syndrome in the elderly: an updated systematic review and meta-analysis of randomized controlled trials
Invasive versus conservative strategies for non-ST-elevation acute coronary syndrome in the elderly: an updated systematic review and meta-analysis of randomized controlled trials Open
In elderly patients with NSTE-ACS, an invasive strategy reduces revascularization needs and, potentially, MI risk without impacting survival, but at the cost of increased bleeding risk. This supports individualized treatment decisions base…
View article: Burden of diseases attributable to excess body weight in 204 countries and territories, 1990–2019
Burden of diseases attributable to excess body weight in 204 countries and territories, 1990–2019 Open
View article: Predicting the Presence of Traumatic Chest Injuries Using Machine Learning Algorithm.
Predicting the Presence of Traumatic Chest Injuries Using Machine Learning Algorithm. Open
Our study highlights the strong potential of machine learning models, especially Random Forest and Gradient Boosting, in predicting chest trauma outcomes with high accuracy and sensitivity.
View article: Unexpected Heartbreak: A Case Report of Takotsubo Cardiomyopathy Triggered by Electroconvulsive Therapy
Unexpected Heartbreak: A Case Report of Takotsubo Cardiomyopathy Triggered by Electroconvulsive Therapy Open
A 73‐year‐old woman who suffered from major depressive disorder was candidated to receive electroconvulsive therapy (ECT) in combination with medical treatment. Shortly after ECT, she complained of severe chest pain. ECG findings revealed …
View article: Beyond the Beat, Next‐Generation Sequencing Discovery of Novel <i>RYR2</i> Gene Variant in Long QT Syndrome
Beyond the Beat, Next‐Generation Sequencing Discovery of Novel <i>RYR2</i> Gene Variant in Long QT Syndrome Open
Background: Long QT syndrome (LQTS) is an inherited cardiac channelopathy marked by QT interval prolongation and increased risk of life‐threatening arrhythmias. While variants in KCNQ1 , KCNH2 , and SCN5A explain most cases, many remain ge…
View article: Machine Learning Models for Predicting Abnormal Brain CT Scan Findings in Mild Traumatic Brain Injury Patients.
Machine Learning Models for Predicting Abnormal Brain CT Scan Findings in Mild Traumatic Brain Injury Patients. Open
XGBoost and Random Forest achieved high predictive accuracy, sensitivity, and specificity. GCS, SpO2, and respiratory rate were key predictors. These models may reduce unnecessary CT scans and optimize resource use. Further multicenter val…
View article: Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges
Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges Open
Background Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired reasoning. It is the leading cause of dementia in older adults, marked by the pathologic…
View article: Global burden of multiple sclerosis and its attributable risk factors, 1990–2019
Global burden of multiple sclerosis and its attributable risk factors, 1990–2019 Open
Background Multiple sclerosis (MS) is a progressively debilitating disorder that has seen a notable rise in prevalence in recent years. This study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, sex, and …
View article: Boosting immunotherapy efficacy: Empowering the Potency of Dendritic cells loaded with breast cancer lysates through CTLA-4 suppression
Boosting immunotherapy efficacy: Empowering the Potency of Dendritic cells loaded with breast cancer lysates through CTLA-4 suppression Open
Anticancer immunotherapies with a dendritic Cell (DC) basis are becoming more popular. However, it has been suggested that the tumor's immunosuppressive mechanisms, such as inhibitory immunological checkpoint molecules, reduce the effectiv…
View article: Value of cardiac magnetic resonance feature-tracking in Arrhythmogenic Cardiomyopathy (ACM): A systematic review and meta-analysis
Value of cardiac magnetic resonance feature-tracking in Arrhythmogenic Cardiomyopathy (ACM): A systematic review and meta-analysis Open
View article: Identification of a novel likely pathogenic <i>TPM1</i> variant linked to hypertrophic cardiomyopathy in a family with sudden cardiac death
Identification of a novel likely pathogenic <i>TPM1</i> variant linked to hypertrophic cardiomyopathy in a family with sudden cardiac death Open
Aims Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic cardiac disorder characterized by unexplained left ventricular hypertrophy. It can cause a wide spectrum of clinical manifestations, ranging from asymptomatic to heart…
View article: Kidney cancer in the Middle East and North Africa region: a 30-year analysis (1990–2019)
Kidney cancer in the Middle East and North Africa region: a 30-year analysis (1990–2019) Open
View article: Successful Percutaneous Closure of an Undiagnosed Patent Ductus Arteriosus Causing Type 2 Endoleak
Successful Percutaneous Closure of an Undiagnosed Patent Ductus Arteriosus Causing Type 2 Endoleak Open
Thoracic endovascular repair (TEVAR) is a valuable alternative to open surgical repair for aortic aneurysms, offering several benefits. However, one potential complication that demands attention is endoleak. This case report highlights a u…
View article: Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies
Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies Open
View article: Prevalence of contrast-induced nephropathy after primary percutaneous coronary intervention at a tertiary referral hospital
Prevalence of contrast-induced nephropathy after primary percutaneous coronary intervention at a tertiary referral hospital Open
While heart failure, radial access, hypercholesterolemia, elevated BUN at admission, and leukocytosis significantly influenced renal filtration deterioration post-PPCI, it's evident that CIN is multifactorial. Further studies are crucial t…
View article: A novel pathogenic variant in the carnitine transporter gene, SLC22A5, in association with metabolic carnitine deficiency and cardiomyopathy features
A novel pathogenic variant in the carnitine transporter gene, SLC22A5, in association with metabolic carnitine deficiency and cardiomyopathy features Open
Background Primary carnitine deficiency (PCD) denotes low carnitine levels with an autosomal recessive pattern of inheritance. Cardiomyopathy is the most common cardiac symptom in patients with PCD, and early diagnosis can prevent complica…
View article: Combined Mesenchymal Stem Cell and Schwann Cell Therapy in Spinal Cord Injury: A 9-Year Cohort Study
Combined Mesenchymal Stem Cell and Schwann Cell Therapy in Spinal Cord Injury: A 9-Year Cohort Study Open
View article: Hypertension in Cardio-Oncology Clinic: an update on etiology, assessment, and management
Hypertension in Cardio-Oncology Clinic: an update on etiology, assessment, and management Open
Hypertension is one of the most common comorbidity and the leading cause of cancer-related death in cancer patients. The prevalence of hypertension in cancer patients is much higher than that of the general population. In the older populat…
View article: siRNA-Mediated B7H7 Knockdown in Gastric Cancer Lysate-Loaded Dendritic Cells Amplifies Expansion and Cytokine Secretion of Autologous T Cells
siRNA-Mediated B7H7 Knockdown in Gastric Cancer Lysate-Loaded Dendritic Cells Amplifies Expansion and Cytokine Secretion of Autologous T Cells Open
Background: Gastric cancer, ranked as the fifth most common cancer worldwide, presents multiple treatment challenges. These obstacles often arise due to cancer stem cells, which are associated with recurrence, metastasis, and drug resistan…
View article: The association between heavy metal exposure and obesity: A systematic review and meta-analysis
The association between heavy metal exposure and obesity: A systematic review and meta-analysis Open
View article: The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study
The predictive value of cardiac MRI strain parameters in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction and a low fibrosis burden: a retrospective cohort study Open
Background Prompt interventions prevent adverse events (AE) in hypertrophic cardiomyopathy (HCM). We evaluated the pattern and the predictive role of feature tracking (FT)-cardiac magnetic resonance (CMR) imaging parameters in an HCM popul…
View article: Non‐spinal low back pain: Global epidemiology, trends, and risk factors
Non‐spinal low back pain: Global epidemiology, trends, and risk factors Open
Background and Aims Low back pain (LBP) is one of the most debilitating and prevalent disorders. The prevalence of LBP ranges from 30% to 80%, depending on the population, and increases with age. Causes of LBP are typically classified as s…
View article: Surgical Outcomes of Repairing Ebstein Anomaly: A Single-Center Experience
Surgical Outcomes of Repairing Ebstein Anomaly: A Single-Center Experience Open
Background: Ebstein anomaly (EA) is a rare congenital disorder of the tricuspid valve (TV), accounting for about one percent of congenital heart defects. Considering highly variable anatomy, diverse corrective surgical methods are currentl…