Explanipedia

SUN-463 Efficacy and Safety of Relacorilant in Individuals With Adrenal Hypercortisolism: Results From the Phase 3 GRACE and GRADIENT Studies Open

Ulrich Dischinger, Amer Al‐Karadsheh, Corin Badiu, Filippo Ceccato, Honey E. East , et al. · 2025

Disclosure: U. Dischinger: Recordati, Novo Nordisk, Alnylam, Merck. A. Al-Karadsheh: None. C. Badiu: Corcept Therapeutics, Lundbeck, Novo Nordisk, Ipsen, Merck, Pfizer, Inc. F. Ceccato: Novartis Pharmaceuticals, HRA Pharmaceuticals, Novo N…

OR16-08 Baxdrostat in Patients with Primary Aldosteronism: Results from the SPARK Phase 2 Trial Open

Irina Bancos, Anat Ben-Shlomo, Oksana Hamidi, Amir H. Hamrahian, Wenyu Huang , et al. · 2025

Disclosure: I. Bancos: AstraZeneca. A. Ben-Shlomo: AstraZeneca. O. Hamidi: Recordati Rare Diseases, Neurocrine Biosciences, Corcept Therapeutics, Crinetics, Camurus, Xeris. A. Hamrahian: AstraZeneca. W. Huang: None. L.S. Kirschner: Corcept…

SUN-294 Urinary Bladder Paraganglioma With POT1 and RECQL4 Mutations Almost Missed by Ga-68 DOTATATE PET/CT Open

Vidhu Vadini, Andrés Matoso, Nirmish Singla, Ronadip R. Banerjee, Amir H. Hamrahian , et al. · 2025

Disclosure: V. Vadini: None. A. Matoso: None. N. Singla: None. R.R. Banerjee: None. A.H. Hamrahian: None. S.M. Chen Cardenas: None. Background: Urinary bladder paragangliomas (UBPGL) are exceedingly rare, constituting <1% of all paragan…

MON-511 Large Bilateral Primary Adrenal Lymphoma: Anatomic and Functional Recovery of Primary Adrenal Insufficiency after R-CHOP Open

Vidisha Master, Elliot K. Fishman, Huili Li, Amir H. Hamrahian, Stanley M. Chen Cardenas · 2025

Disclosure: V. Master: None. E.K. Fishman: None. H. Li: None. A.H. Hamrahian: None. S.M. Chen Cardenas: None. Background: Primary adrenal lymphomas are exceedingly rare, with only a few hundred cases reported in the literature. Of those, a…

IPSS does not impact management in Cushing's Disease when a pituitary tumor is visible on MRI Open

Michelle D. Lundholm, Kevin M. Pantalone, Pratibha P R Rao, Amir H. Hamrahian, Varun R. Kshettry , et al. · 2025

Purpose: There is controversy surrounding the value of inferior petrosal sinus sampling (IPSS) in Cushing's Disease (CD) when there is a visible pituitary lesion on pre-operative imaging. This study compares lateralization results between …

7428 Clinical and Radiological Characterization and Outcomes of Lipid-Poor Adrenal Masses- A Multi-Center Retrospective Study Open

Vania Balderrama-Brondani, Ruaa Al-Ward, K Kiseljak-Vassiliades, Lauren Fishbein, Danielle Kirelik , et al. · 2024

Disclosure: V. Balderrama-Brondani: None. R. Al-ward: None. K. Kiseljak-Vassiliades: None. L.M. Fishbein: None. D.A. Kirelik: None. O. Hamidi: None. R. Pishdad: None. H.K. Ghayee: None. M. Sukkari: None. S.S. Bedrose: None. A.H. Hamrahian:…

6903 The Treatment May Be Worse Than The Disease: The Real-World Clinical Burden Of Disease And Treatment In Congenital Adrenal Hyperplasia Open

Wenyu Huang, R Will Charlton, Saba Sile, Christopher Dieyi, Shayna Adams , et al. · 2024

Disclosure: W. Huang: Consulting Fee; Self; Spruce Biosciences. Research Investigator; Self; Spruce Biosciences. R. Charlton: Employee; Self; Spruce Biosciences. S. Sile: Employee; Self; Spruce Biosciences. C. Dieyi: Employee; Self; STATin…

7465 Impact Of Geography And Insurance On Healthcare Utilization Preferences Of Individuals With Congenital Adrenal Hyperplasia In The United States Open

Prasanth Surampudi, Amir H. Hamrahian, Roger Charlton, P J Ramtin, Mitchell E. Geffner · 2024

Disclosure: P.N. Surampudi: Research Investigator; Self; Spruce Biosciences. A.H. Hamrahian: Consulting Fee; Self; Spruce Biosciences. Research Investigator; Self; Spruce Biosciences. R. Charlton: Employee; Self; Spruce Biosciences. P. Ram…

9294 Clinical and Radiological Characterization And Outcomes of Lipid-Poor Adrenal Masses- A Multi-Center Retrospective Study Open

Vania Balderrama-Brondani, Ruaa Al-Ward, Katja Kiseljak‐Vassiliades, Lauren Fishbein, Danielle Kirelik , et al. · 2024

Disclosure: V. Balderrama-Brondani: None. R. Al-ward: None. K. Kiseljak-Vassiliades: None. L.M. Fishbein: None. D.A. Kirelik: None. O. Hamidi: None. R. Pishdad: None. H.K. Ghayee: None. M. Sukkari: None. S.S. Bedrose: None. A.H. Hamrahian:…

Fully-automated CT derived body composition analysis reveals sarcopenia in functioning adrenocortical carcinomas Open

Prasanna Santhanam, Roshan Dinparastisaleh, Karteek Popuri, Mirza Faisal Beg, Stanley M. Chen Cardenas , et al. · 2024

Determination of body composition (the relative distribution of fat, muscle, and bone) has been used effectively to assess the risk of progression and overall clinical outcomes in different malignancies. Sarcopenia (loss of muscle mass) is…

Response to Letter to the Editor From S. I. Taylor et al: “Type B Insulin Resistance Syndrome: A Rare Cause of Hypoglycemia” Open

Salman Zahoor Bhat, Sooyoung Lim, Aniket Sidhaye, Amir H. Hamrahian · 2024

THU392 Type B Insulin Resistance: A Rare Cause Of Hypoglycemia Open

Salman Zahoor Bhat, Aniket Sidhaye, Amir H. Hamrahian · 2023

Disclosure: S.Z. Bhat: None. A. Sidhaye: None. A.H. Hamrahian: None. Introduction: Non-diabetic hypoglycemia in patients with diabetes mellitus is rare. Type B insulin resistance syndrome (TBIRS), caused by insulin receptor antibodies, pre…

Acute heart failure with incidentally found cystic adrenal mass Open

Salman Zahoor Bhat, Amir H. Hamrahian, Yubo Wu, Misop Han, Roberto Salvatori · 2023

Summary Pheochromocytomas are rare adrenal tumors characterized by excessive catecholamine secretion. Symptoms and signs associated with pheochromocytomas are usually intermittent and chronic but can rarely develop into life-threatening cr…

Type B Insulin Resistance Syndrome: A Rare Cause of Hypoglycemia Open

Salman Zahoor Bhat, Sooyoung Lim, Aniket Sidhaye, Amir H. Hamrahian · 2023

We describe a case of a Black female patient with a history of type 2 diabetes mellitus and systemic lupus erythematosus, who had a subacute onset of severe hypoglycemia that persisted after cessation of insulin therapy. Biochemical testin…

Development of an Empty Sella Open

Stanley M. Chen Cardenas, Debraj Mukherjee, Amir H. Hamrahian · 2023

The Addition of Corticotropin-Releasing Hormone to 2-day Low Dose Dexamethasone Suppression Test Provides Additional Case Detection Open

Leen Wehbeh, Ula Abed Alwahab, Alexandra Mikhael, Georgiana Dobri, Divya Yogi-Morren , et al. · 2022

PURPOSE: To assess the diagnostic value of adding a Corticotropin-Releasing Hormone (CRH) Stimulation Test to the 2-day Low Dose Dexamethasone Suppression Test (Dex-CRH Test). METHODS: We identified 65 patients with Cushing disease (CD) an…

Perioperative Evaluation and Management of Patients on Glucocorticoids Open

Stanley M. Chen Cardenas, Prasanna Santhanam, Lilah F. Morris, Roberto Salvatori, Amir H. Hamrahian · 2022

Myriad questions regarding perioperative management of patients on glucocorticoids (GCs) continue to be debated including which patients are at risk for adrenal insufficiency (AI), what is the correct dose and duration of supplemental GCs,…

ODP036 Cortisol Values During the Standard-Dose Cosyntropin Stimulation Test: Personal Experience with Elecsys Cortisol II Assay Open

Amir H. Hamrahian, Roshan Dinparastisaleh, Hasan Husni, Mohammed S. Abusamaan, Lori J. Sokoll , et al. · 2022

Background There has been debate regarding the appropriate cortisol cutoffs during the cosyntropin stimulation test (CST) when the newer cortisol assays are used. Recent studies have recommended cortisol cutoffs lower than previously recom…

PMON152 In Patients with Cushing's Disease and a Visible Tumor on MRI, IPSS does not Add to the Accuracy of Predicting Tumor Lateralization Open

Michelle D. Lundholm, Kevin M. Pantalone, Pratibha Rao, Amir H. Hamrahian, Divya Yogi-Morren · 2022

Introduction There is controversy surrounding the value of bilateral inferior petrosal sinus sampling (BIPSS) for tumor lateralization in Cushing's disease (CD). We compare lateralization results between BIPSS and pituitary imaging against…

Histopathologic Differences Between Adrenocorticotropic Hormone–Dependent and Adrenocorticotropic Hormone–Independent Adrenal Hyperplasia Causing Cushing Syndrome Open

Reza Pishdad, Ezra Baraban, Lilah F. Morris, Stanley M. Chen Cardenas, Roberto Salvatori , et al. · 2022

A 64-year-old man with cushingoid features was found to have bilateral nodular adrenal masses (left > right). Laboratory studies showed elevated 24-hour urinary free cortisol level at 64 μg (reference range, 0-50 μg), abnormal levels for t…

Cortisol values during the standard-dose cosyntropin stimulation test: Personal experience with Elecsys cortisol II assay Open

Hasan Husni, Mohammed S. Abusamaan, Roshan Dinparastisaleh, Lori J. Sokoll, Roberto Salvatori , et al. · 2022

Purpose There has been debate regarding the appropriate cortisol cutoff during the cosyntropin stimulation test (CST) when newer cortisol assays are used. We aimed to evaluate the proper cortisol values during the standard dose CST in pati…

Pasireotide use for the treatment of endogenous hyperinsulinemic hypoglycemia refractory to conventional medical therapy: A case report and review of the literature Open

Hasan Husni, Sara Atiq Khan, Buraq Alghaieb, Mohammed S. Abusamaan, Thomas Donner , et al. · 2022

Insulinomas are rare neuroendocrine pancreatic tumors that can be associated with severe episodes of hypoglycemia, leading to significant morbidity and mortality. These tumors are often difficult to localize, and hypoglycemia control can b…

Response to Letter to the Editor From Lukas Andereggen: “Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review” Open

Jordan E. Perlman, Robert J. Weil, Ferdinand Hui, Pablo F. Recinos, Gary L. Gallia , et al. · 2021

The Dexamethasone-CRH Stimulation Test: A Single-Center Experience Open

Leen Wehbeh, Ula Abed Alwahab, Alexandra Mikhael, Georgiana Dobri, Laurence Kennedy , et al. · 2021

Background: The diagnostic value of adding a Corticotropin Releasing Hormone (CRH) Stimulation Test to the 2-day Low Dose Dexamethasone Suppression Test (Dex-CRH Test) has been debated in the literature. We hypothesized that adding CRH to …

Dural Tail Sign in Meningiomas Open

Hasan Husni, Amir H. Hamrahian · 2021

A 36-year-old woman with a history of migraine was referred to our clinic for evaluation of the hypothalamic-pituitary axis. She complained of dizziness and decreased visual acuity 4 months prior to the presentation. Brain magnetic resonan…

Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review Open

Jordan E. Perlman, Philip C Johnston, Ferdinand Hui, Guy B. Mulligan, Robert J. Weil , et al. · 2021

Context Inferior petrosal sinus sampling (IPSS) helps differentiate the source of ACTH-dependent hypercortisolism in patients with inconclusive biochemical testing and imaging, and is considered the gold standard for distinguishing Cushing…

Preoperative BMI Predicts Postoperative Weight Gain in Adult-onset Craniopharyngioma Open

Daisy Duan, Leen Wehbeh, Debraj Mukherjee, Amir H. Hamrahian, Fausto J. Rodríguez , et al. · 2021

Context Craniopharyngiomas, while benign, have the highest morbidity of all nonmalignant sellar tumors. Studies on weight and metabolic outcomes in adult-onset craniopharyngioma (AOCP) remain sparse. Objective To examine postsurgical weigh…

American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach Open

Katja Kiseljak‐Vassiliades, Irina Bancos, Amir H. Hamrahian, Mouhammed Amir Habra, Anand Vaidya , et al. · 2020

Acromegaly: a clinical perspective Open

Lima Lawrence, Kenda Alkwatli, James Bena, Richard A. Prayson, Varun R. Kshettry , et al. · 2020

Background To examine the clinical and hormonal profiles, comorbidities, treatment patterns, surgical pathology and clinical outcomes of patients diagnosed with acromegaly at the Cleveland Clinic over a 15-year period. Methods A retrospect…

Unusual Combination of MEN-1 and the Contiguous Gene Deletion Syndrome of CAH and Ehlers-Danlos Syndrome (CAH-X) Open

Stanley M. Chen Cardenas, Samer El-Kaissi, Ola Jarad, Muneezeh Liaqat, Márta Korbonits , et al. · 2020

The contiguous gene deletion syndrome of congenital adrenal hyperplasia and Ehlers-Danlos syndrome, named CAH-X, is a rare entity that occurs because of a deletion of a chromosomal area containing 2 neighboring genes, TNXB and CYP21A. Here…

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