Majid Sadeghizadeh
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View article: Nano-curcumin enhances the sensitivity of tamoxifen-resistant breast cancer cells via the Cyclin D1-DILA1 axis and the PI3K/AKT/mTOR pathway downregulation
Nano-curcumin enhances the sensitivity of tamoxifen-resistant breast cancer cells via the Cyclin D1-DILA1 axis and the PI3K/AKT/mTOR pathway downregulation Open
This research investigates the effects of nano-curcumin on the expression of Cyclin D1 and DILA1 genes, as well as on the PI3K/AKT/mTOR pathway, in tamoxifen-sensitive and resistant MCF-7 breast cancer cell lines. The IC50 values were dete…
View article: Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in <i>Staphylococcus aureus</i> Isolated from Burn Wounds.
Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in <i>Staphylococcus aureus</i> Isolated from Burn Wounds. Open
Nanocurcumin inhibits S. aureus virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on fnbA and ftsZ, requiring further research.
View article: Novel curcumin nanocarrier for targeting drug delivery of mitochondria proves efficacy in in vivo experiments on hepatocellular carcinoma mice models
Novel curcumin nanocarrier for targeting drug delivery of mitochondria proves efficacy in in vivo experiments on hepatocellular carcinoma mice models Open
Hepatocellular carcinoma (HCC) remains difficult to treat due to systemic toxicity of non-selective therapies. To address this, we hypothesized that targeting the highly active mitochondria of cancer cells, which have considerably increase…
View article: Predicting Condominium Prices in Malaysia: A Comparative Analysis of Machine Learning Models
Predicting Condominium Prices in Malaysia: A Comparative Analysis of Machine Learning Models Open
View article: Dual functions of the ΔNp63-miR-141-3p-YAP1 regulatory axis in cervical cancer progression are dependent on histological subtype
Dual functions of the ΔNp63-miR-141-3p-YAP1 regulatory axis in cervical cancer progression are dependent on histological subtype Open
View article: Development of a multi-neoepitope vaccine targeting non-small cell lung cancer through reverse vaccinology and bioinformatics approaches
Development of a multi-neoepitope vaccine targeting non-small cell lung cancer through reverse vaccinology and bioinformatics approaches Open
Introduction Lung cancer, predominantly non-small cell lung cancer (NSCLC), is the leading cause of cancer-related mortality worldwide. Among immunotherapeutic strategies, the personalized multi-neoepitope vaccine (MNEV) offers a promising…
View article: Inaccuracy of An Examination of Grammatical Error
Inaccuracy of An Examination of Grammatical Error Open
When it comes to the construction of a communication process, grammar plays a significant part. It is utilized to make a clear declaration about the time at which a verb happens. The purpose of this study is to identify grammatical faults …
View article: Restoring Tamoxifen Sensitivity in Breast Cancer: The Role of lncRNA MALAT1 and NanoCurcumin as Modulators of Drug Resistance
Restoring Tamoxifen Sensitivity in Breast Cancer: The Role of lncRNA MALAT1 and NanoCurcumin as Modulators of Drug Resistance Open
Background: Tamoxifen resistance remains a major clinical challenge in estrogen receptor–positive (ER+) breast cancer, contributing to recurrence and poor prognosis. Long noncoding RNAs (lncRNAs), including MALAT1, UCA1, CYTOR, GAS5, and H…
View article: Intelligent guide RNA: dual toehold switches for modulating luciferase in the presence of trigger RNA
Intelligent guide RNA: dual toehold switches for modulating luciferase in the presence of trigger RNA Open
View article: Dendrosomal Curcumin Showed Cytotoxic Effects on Breast Cancer Cell Line by Inducing Mitochondrial Apoptosis Pathway and Cell Division Arrest
Dendrosomal Curcumin Showed Cytotoxic Effects on Breast Cancer Cell Line by Inducing Mitochondrial Apoptosis Pathway and Cell Division Arrest Open
Background: Mutations in the p53 gene have been linked to the initiation and progression of breast cancer, as well as resistance to chemotherapy. Therefore, the development of novel treatment approaches is essential to combat this disease.…
View article: Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model
Preventive and treatment efficiency of dendrosomal nano-curcumin against ISO-induced cardiac fibrosis in mouse model Open
Cardiac fibrosis (c-fibrosis) is a critical factor in cardiovascular diseases, leading to impaired cardiac function and heart failure. This study aims to optimize the isoproterenol (ISO)-induced c-fibrosis model and evaluate the therapeuti…
View article: Synergistic effect of curcumin and tamoxifen loaded in pH-responsive gemini surfactant nanoparticles on breast cancer cells
Synergistic effect of curcumin and tamoxifen loaded in pH-responsive gemini surfactant nanoparticles on breast cancer cells Open
View article: Dual roles of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines
Dual roles of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines Open
Cervical cancer (CC) represents a substantial public health burden, requiring the development of inventive therapeutic approaches. This study explored the functional relationship between the p63 isoform (ΔNp63) and miR-141-3p in modulating…
View article: Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines
Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines Open
Cervical cancer (CC) represents a substantial public health burden, requiring the development of inventive therapeutic approaches. This study explored the functional relationship between the p63 isoform (ΔNp63) and miR-141-3p in modulating…
View article: Evaluation of the Expression Level of Some Coding and Non-coding Genes in Breast Cancer Samples Based on Bioinformatics and Laboratory Studies
Evaluation of the Expression Level of Some Coding and Non-coding Genes in Breast Cancer Samples Based on Bioinformatics and Laboratory Studies Open
Background: Breast cancer (BC) is the leading cause of cancer-associated mortality in women worldwide. However, the molecular mechanism underlying the process is still unclear. In this regard, bioinformatics studies play a decisive role in…
View article: Encapsulation of propolis extracted with methylal in the chitosan nanoparticles and its antibacterial and cell cytotoxicity studies
Encapsulation of propolis extracted with methylal in the chitosan nanoparticles and its antibacterial and cell cytotoxicity studies Open
In this study we develop novel type of antibacterial chitosan-propolis NPs to improve theantimicrobial activity against various pathogens. To this aim, we primarily extracted propolis with methylal and ethanol as green solvents and its enc…
View article: Intra-abdominal transplantation of PLGA/PCL/M13 phage electrospun scaffold induces self-assembly of lymphoid tissue-like structure
Intra-abdominal transplantation of PLGA/PCL/M13 phage electrospun scaffold induces self-assembly of lymphoid tissue-like structure Open
Lymphoid organs are the main structural components of the immune system. In the current research, the mixture of poly lactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and M13 phage or its RGD-modified form was used in the constructi…
View article: MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways
MicroRNA-203a inhibits breast cancer progression through the PI3K/Akt and Wnt pathways Open
MicroRNA expression in breast cancer (BC) is explored both as a potential biomarker and for therapeutic purposes. Recent studies have revealed that miR-203a-3p is involved in BC, and importantly contributes to BC chemotherapy responses; ho…
View article: Intelligent Guide RNA: Harboring Dual Toe-Hold Switches for Luciferase Reporter Modulation in the Presence of Trigger RNA
Intelligent Guide RNA: Harboring Dual Toe-Hold Switches for Luciferase Reporter Modulation in the Presence of Trigger RNA Open
The CRISPR system has been extensively utilized in various aspects of molecular biology for over a decade. However, its continuous activity can result in undesirable effects. Nevertheless, implementing programmable CRISPR/Cas9 function usi…
View article: CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in glioblastoma multiforme
CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in glioblastoma multiforme Open
Background GBM is the most frequent malignant primary brain tumor in humans. The CLEC19A is a member of the C-type lectin family, which has a high expression in brain tissue. Herein, we sought to carry out an in-depth analysis to pinpoint …
View article: The Effect of Dendrosomal Nanocurcumin on Wnt/Β-Catenin Signaling Pathway Via Piwil2 in Mcf-7 Breast Cancer Cells
The Effect of Dendrosomal Nanocurcumin on Wnt/Β-Catenin Signaling Pathway Via Piwil2 in Mcf-7 Breast Cancer Cells Open
View article: Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions Open
Mesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a variety of adult tissues. MSCs possess a remarkable ability to migrate towards tumor sites, known as homing. This homing process is mediated by various f…
View article: CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in Glioblastoma Multiforme
CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in Glioblastoma Multiforme Open
Background: GBM is the most frequent malignant primary brain tumor in humans. The CLEC19A is a member of the C-type lectin family, which has a high expression in brain tissue. Herein, we sought to carry out an in-depth analysis to pinpoint…
View article: Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis
Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis Open
Background Hepatocellular Carcinoma (HCC) is a prevalent form of liver cancer that causes significant mortality in numerous individuals worldwide. This study compared the effects of milk thistle (MT) and nano-milk thistle (N-MT) on the exp…
View article: Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies
Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies Open
View article: <scp><i>LINC01116</i></scp> affects patient survival differently and is dissimilarly expressed in <scp>ER</scp>+ and <scp>ER</scp>− breast cancer samples
<span><i>LINC01116</i></span> affects patient survival differently and is dissimilarly expressed in <span>ER</span>+ and <span>ER</span>− breast cancer samples Open
Background Breast cancer is the most commonly detected cancer and one of the leading causes of cancer mortality. Emerging evidence supports that aberrant expression of lncRNAs is correlated with tumor progression and various aspects of tum…
View article: Mir-183 functions as an oncogene via decreasing PTEN in breast cancer cells
Mir-183 functions as an oncogene via decreasing PTEN in breast cancer cells Open
View article: OCT4B1 Dysregulation Is a Key Factor in Different Sensitivity of Normal Cells and Breast Cancer Cells to the Curcumin
OCT4B1 Dysregulation Is a Key Factor in Different Sensitivity of Normal Cells and Breast Cancer Cells to the Curcumin Open
OCT4B1 Dysregulation Is a Key Factor in Different Sensitivity of Normal Cells and Breast Cancer Cells to the Curcumin
View article: Dendrosomal nanocurcumin prevents EBV-associated cell transformation by targeting the lytic cycle genes of the Epstein-Barr virus in the generation of lymphoblastoid cell line.
Dendrosomal nanocurcumin prevents EBV-associated cell transformation by targeting the lytic cycle genes of the Epstein-Barr virus in the generation of lymphoblastoid cell line. Open
Overall, these findings show that DNC reduces the expression of the viral lytic cycle genes and also the induction of cell apoptosis and finally prevents the generation of LCL.
View article: Mir-183 functions as an oncogene via decreasing PTEN in breast cancer cells
Mir-183 functions as an oncogene via decreasing PTEN in breast cancer cells Open
Regarding the important role of microRNAs in breast cancer, investigating the molecular mechanisms of miRs and their impacts on breast cancer progression is critical. Thus, the present work aimed to investigate the molecular mechanism of m…