Amir Atashi
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View article: Stage-Specific Effects of Maternal Circadian Rhythm Disruption during Pre-Pregnancy, Pregnancy, and Lactation on Behavioral and Neurobiological Outcomes in Male Rat Offspring
Stage-Specific Effects of Maternal Circadian Rhythm Disruption during Pre-Pregnancy, Pregnancy, and Lactation on Behavioral and Neurobiological Outcomes in Male Rat Offspring Open
Maternal circadian rhythm disruption (CRD) during reproduction is increasingly recognized as a risk factor for long-term neurobehavioral disturbances in offspring. However, the stage-specific consequences of maternal CRD remain poorly unde…
View article: Assessing the prognostic value of long non-coding RNAs in glioblastoma patients: findings from a systematic review and meta-analysis
Assessing the prognostic value of long non-coding RNAs in glioblastoma patients: findings from a systematic review and meta-analysis Open
View article: Investigating the prognostic value of non-coding RNAs in chronic lymphocytic leukemia: insights from a systematic review and meta-analysis
Investigating the prognostic value of non-coding RNAs in chronic lymphocytic leukemia: insights from a systematic review and meta-analysis Open
Background Non-coding RNA (ncRNA) expression dysregulation has been implicated in the prognosis of various cancers. Several mechanisms have been associated with altered expression of the ncRNAs with the progression of chronic lymphocytic l…
View article: <i>In Vivo</i> Therapeutic Potential of Next-Generation Probiotic <i>Akkermansia muciniphila</i> and Butyrate Combination Therapy in Diabetes
<i>In Vivo</i> Therapeutic Potential of Next-Generation Probiotic <i>Akkermansia muciniphila</i> and Butyrate Combination Therapy in Diabetes Open
Recent studies have found that gut microbiota is closely related to the initiation and progression of T1DM. This study aimed to examine the effects of sodium butyrate and Akkermansia muciniphila (AKK), both individually and combined…
View article: Non-coding RNAs in chronic lymphocytic leukemia: A systematic review and meta-analysis to decode the diagnostic potential
Non-coding RNAs in chronic lymphocytic leukemia: A systematic review and meta-analysis to decode the diagnostic potential Open
Both miRNAs and CircRNAs appear to hold promise as non-invasive diagnostic biomarkers in CLL, with miRNAs demonstrating higher diagnostic performance. However, based on the GRADE assessments, the certainty of evidence may undermine the rel…
View article: Engineered exosomes: advanced nanocarriers for targeted therapy and drug delivery in hematological malignancies
Engineered exosomes: advanced nanocarriers for targeted therapy and drug delivery in hematological malignancies Open
Hematological malignancies present significant therapeutic challenges, often complicated by drug resistance, poor bioavailability, and systemic toxicity of conventional treatments. Engineered exosomes have emerged as promising therapeutic …
View article: Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies
Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies Open
View article: The Relationship between the Number of Stem Cells and the Concentration of Stromal Cell-Derived Factor-1 with Disease Severity in Patients with Liver Cirrhosis
The Relationship between the Number of Stem Cells and the Concentration of Stromal Cell-Derived Factor-1 with Disease Severity in Patients with Liver Cirrhosis Open
Background: The chemokine stromal cell-derived factor 1 (SDF-1) is important in tissue repair. In this study, we aimed to investigate the relationship between the number of stem cells in the blood and the blood concentration of stromal cel…
View article: Effect of fibrin on the expression of adhesion molecules (ICAM-1, ITGAV, and ITGB3) in unrestricted somatic stem cells
Effect of fibrin on the expression of adhesion molecules (ICAM-1, ITGAV, and ITGB3) in unrestricted somatic stem cells Open
Our study revealed that fibrin has a positive impact on the expression of ITGAV, which plays a crucial role in direct cell-cell interactions affecting hematopoietic stem cell expansion.
View article: Prognostic value of circular RNAs expression and their correlation with clinicopathological features in acute myeloid leukemia: a systematic review and meta-analysis
Prognostic value of circular RNAs expression and their correlation with clinicopathological features in acute myeloid leukemia: a systematic review and meta-analysis Open
View article: Tumor microenvironment as a novel therapeutic target for lymphoid leukemias
Tumor microenvironment as a novel therapeutic target for lymphoid leukemias Open
Lymphoid leukemias represent a significant global health burden, leading to substantial morbidity and mortality. The intricate interplay between leukemic cells and their surrounding tumor microenvironment (TME) is pivotal in disease initia…
View article: SNHG14 lncRNA as a Prognostic Biomarker in Adult Non-M3 AML Patients
SNHG14 lncRNA as a Prognostic Biomarker in Adult Non-M3 AML Patients Open
Background and Objectives Acute myeloid leukemia (AML) is one of the most common blood malignancies in adults, characterized by the involvement of hematopoietic myeloid progenitors. Numerous studies have demonstrated the involvement of lon…
View article: Anti-cancer effects of frankincense methanolic extract on brain metastatic breast cancer cells.
Anti-cancer effects of frankincense methanolic extract on brain metastatic breast cancer cells. Open
Our findings indicated that frankincense extract has a potent cytotoxic effect on brain metastatic tumor cells and induces apoptosis in these cells. Unlike many anti-cancer drugs which have very little ability to combat and kill brain meta…
View article: Circular RNAs: history, metabolism, mechanisms of function, and regulatory roles at a glance
Circular RNAs: history, metabolism, mechanisms of function, and regulatory roles at a glance Open
Circular RNAs (circRNAs) are non-coding RNA (ncRNA) molecules that, due to their covalent ring structure and lack of free ends, have a very high intracellular stability compared to their linear counterparts. In general, circRNAs are expres…
View article: Experimental and Numerical Investigation of Cold Joint Effects on Intermediate Concrete Moment Frame Under Cyclic Loading
Experimental and Numerical Investigation of Cold Joint Effects on Intermediate Concrete Moment Frame Under Cyclic Loading Open
This study investigates the seismic behavior of reinforced concrete flexural frames with a focus on the impact of cold joints (CJs). Three one-bay concrete frames, scaled to 2:3 according to ACI 318-19(22), were tested under axial and cycl…
View article: GATA1 transcription factor targets the gene expression of B19 virus in HEK293 cell line
GATA1 transcription factor targets the gene expression of B19 virus in HEK293 cell line Open
Background/Aim: B19 virus (B19V) is a single-strand DNA virus that has specific tropism to erythroid progenitor cells (EPCs). The virus enters the cells via P antigen and coreceptors and induces infection and cell apoptosis. GATA1 has a hi…
View article: Integrins linked kinase and focal adhesion kinase as the key signaling mediators of vascular mimicry in metastatic breast tumor cells
Integrins linked kinase and focal adhesion kinase as the key signaling mediators of vascular mimicry in metastatic breast tumor cells Open
View article: Investigating the relationship between lymphocyte cells apoptosis and DNA damage and oxidative stress and therapeutic and clinical outcomes of COVID-19 elderly patients
Investigating the relationship between lymphocyte cells apoptosis and DNA damage and oxidative stress and therapeutic and clinical outcomes of COVID-19 elderly patients Open
It shows that the apoptosis of lymphocyte cells, DNA damage, and oxidative stress can be effective in prognostic decisions and is a suitable predictor for diagnosing the condition of patients with viral infections such as COVID-19 and infl…
View article: Concise review: breast cancer stems cells and their role in metastases
Concise review: breast cancer stems cells and their role in metastases Open
Background: Breast cancer stem cells (BCSCs) have been suggested to be responsible for the development of Breast cancer (BC). The aim of this study was to evaluate BCSCs and the target organs microenvironment immunophenotyping markers in c…
View article: NETosis and SARS-COV-2 Infection-Related Autoimmunity: A Narrative Review
NETosis and SARS-COV-2 Infection-Related Autoimmunity: A Narrative Review Open
Background: Neutrophil extracellular traps (NETs) are crucial for antimicrobial defense in sepsis, trapping and neutralizing pathogens while minimizing damage to host cells. Neutrophil extracellular traps, comprising nuclear chromatin, his…
View article: Survival, Adhesion and Migration of Metastatic Breast Tumor Cells: Roles of Parvins (PARVA and PARVB)
Survival, Adhesion and Migration of Metastatic Breast Tumor Cells: Roles of Parvins (PARVA and PARVB) Open
Changes in cell-ECM interaction can lead to the anchorage-independent proliferation, resistance to apoptosis, and improved motility that characterize breast metastatic cells. The parvin, alpha (Parva) and parvin, beta (Parvb) localizes to …
View article: Unraveling Hematopoietic Stem Cell Expansion: A Microfluidic 3D Co-culture Approach on Demineralized Bone Matrix
Unraveling Hematopoietic Stem Cell Expansion: A Microfluidic 3D Co-culture Approach on Demineralized Bone Matrix Open
Background Hematopoietic stem cell transplantation (HSCT) is a well-established therapy for various hematological malignancies. Umbilical cord blood (UCB) HSCs offer an alternative source but are limited by a small number of CD34 + cells, …
View article: Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A
Biological study of skin wound treated with Alginate/Carboxymethyl cellulose/chorion membrane, diopside nanoparticles, and Botox A Open
View article: Effects of Tumor Microenvironment on the Primo Vascular Pattern in the Mouse Model of Metastatic Breast Cancer
Effects of Tumor Microenvironment on the Primo Vascular Pattern in the Mouse Model of Metastatic Breast Cancer Open
: For the first time, our data gave significant new information about the PVS in TNBC. Creating new anti-cancer treatments may be made possible by a better understanding of the biological characteristics of the TME and PVS.
View article: Prognostic value of circular RNAs expression and correlation with clinicopathological features in acute myeloid leukemia; a comprehensive systematic review and meta-analysis
Prognostic value of circular RNAs expression and correlation with clinicopathological features in acute myeloid leukemia; a comprehensive systematic review and meta-analysis Open
Background Acute myeloid leukemia (AML) prognosis is affected by unique factors to each individual and studies have indicated that dysregulated expression of circRNAs may serve as prognostic biomarkers for AML. Therefore, we conducted this…
View article: Injectable multifunctional hydrogel containing Sphingosine 1-phosphate and human acellular amniotic membrane for skin wound healing.
Injectable multifunctional hydrogel containing Sphingosine 1-phosphate and human acellular amniotic membrane for skin wound healing. Open
This study demonstrates the effectiveness of the CMC/Gel/EDC hydrogel with S1P as a wound dressing. Additionally, hAAM exhibits excellent characteristics as a protective layer for the treatment of acute wounds.
View article: Upregulation of Matrix Metalloproteinases in the Metastatic Cascade of Breast Cancer to the Brain
Upregulation of Matrix Metalloproteinases in the Metastatic Cascade of Breast Cancer to the Brain Open
These results offer significant information about the massive alteration of MMPs expression in the brain metastasis of TNBC. By analyzing the molecular characteristics of brain metastatic tumor cells, we can understand the molecular and ge…
View article: Downregulation of circ-Foxo3 in breast cancer stem-like cells
Downregulation of circ-Foxo3 in breast cancer stem-like cells Open
Objective Cancer cells having stem cell characteristics are linked to metastasis and relapse in breast cancer. Circ-Foxo3, as a circular RNA, has been linked to the breast cancer lethal traits. This study’s objective was to assess circ-Fox…
View article: SNHG14 lncRNA as a tumor suppressor in adult non-M₃ AML patients; The diagnostic biomarker
SNHG14 lncRNA as a tumor suppressor in adult non-M₃ AML patients; The diagnostic biomarker Open
Acute myeloid leukemia (AML) is one of the most common adult blood malignancies that engages hematopoietic myeloid progenitors. A large number of studies have shown the involvement of long non-coding RNAs (lncRNAs) in AML pathogenesis. Thi…
View article: Recent advances on 3D-printed PCL-based composite scaffolds for bone tissue engineering
Recent advances on 3D-printed PCL-based composite scaffolds for bone tissue engineering Open
Population ageing and various diseases have increased the demand for bone grafts in recent decades. Bone tissue engineering (BTE) using a three-dimensional (3D) scaffold helps to create a suitable microenvironment for cell proliferation an…