Amir Rattner
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View article: Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation Open
In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous syste…
View article: Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation Open
In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous syste…
View article: Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation Open
In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for transforming growth factor-beta receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous syste…
View article: Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation Open
In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous syste…
View article: Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution
Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution Open
The lacrimal gland is of central interest in ophthalmology both as the source of the aqueous component of tear fluid and as the site of autoimmune pathology in the context of Sjogren’s syndrome (SjS). To provide a foundational description …
View article: Bacterial meningitis in the early postnatal mouse studied at single-cell resolution
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution Open
Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here, we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using sin…
View article: Author response: Bacterial meningitis in the early postnatal mouse studied at single-cell resolution
Author response: Bacterial meningitis in the early postnatal mouse studied at single-cell resolution Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Bacteri…
View article: Bacterial meningitis in the early postnatal mouse studied at single-cell resolution
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution Open
Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using sing…
View article: Signaling Pathways in Neurovascular Development
Signaling Pathways in Neurovascular Development Open
During development, the central nervous system (CNS) vasculature grows to precisely meet the metabolic demands of neurons and glia. In addition, the vast majority of the CNS vasculature acquires a unique set of molecular and cellular prope…
View article: Author response: A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation
Author response: A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The iris controls the …
View article: A transcriptome atlas of the mouse iris at single cell resolution defines cell types and the genomic response to pupil dilation
A transcriptome atlas of the mouse iris at single cell resolution defines cell types and the genomic response to pupil dilation Open
The iris controls the level of retinal illumination by controlling pupil diameter. It is a site of diverse ophthalmological diseases and it is a potential source of cells for ocular auto-transplantation. The present study provides foundati…
View article: Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus
Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus Open
In the hippocampus, a widely accepted model posits that the dentate gyrus improves learning and memory by enhancing discrimination between inputs. To test this model, we studied conditional knockout mice in which the vast majority of denta…
View article: Roles of HIFs and VEGF in angiogenesis in the retina and brain
Roles of HIFs and VEGF in angiogenesis in the retina and brain Open
Vascular development in the mammalian retina is a paradigm for CNS vascular development in general, and its study is revealing fundamental mechanisms that explain the efficacy of antiangiogenic therapies in retinal vascular disease. During…
View article: Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution Open
The mammalian CNS is capable of tolerating chronic hypoxia, but cell type-specific responses to this stress have not been systematically characterized. In the Norrin KO ( Ndp KO ) mouse, a model of familial exudative vitreoretinopathy (FEV…
View article: Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures Open
The brain, spinal cord, and retina are supplied by capillaries that do not permit free diffusion of molecules between serum and parenchyma, a property that defines the blood-brain and blood-retina barriers. Exceptions to this pattern are f…
View article: Author response: Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
Author response: Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The brain, spinal cord, and retina are sup…
View article: Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions
Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions Open
Defining protein-protein interactions (PPIs) is central to the biological sciences. Here, we present a novel platform - Affinity Capture of Polyribosomes followed by RNA sequencing (ACAPseq) - for identifying PPIs. ACAPseq harnesses the po…
View article: Author response: Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions
Author response: Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Defining protein-protein interactions (PPI…
View article: Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells Open
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular and cellular specializations. To explore genomic mechanisms that control this specialization, we have analyzed and compared the transcriptome, accessib…
View article: Author response: Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Author response: Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Vascular endothelial cell (EC) function de…