Explanipedia

Telehealth pulmonary rehabilitation enhances functional capacity and quality of life in veterans with chronic obstructive pulmonary disease: a 12-week single-arm intervention study Open

Mehrnaz Azarian, Mon S. Bryant, Christina Nguyen, Naima Rodriguez, Amir Sharafkhaneh , et al. · 2025

Traditional in-person pulmonary rehabilitation protocols enhance respiratory health and functional capacity in Chronic Obstructive Pulmonary Disease (COPD) patients but face scalability issues due to high dropout rates and poor acceptabili…

Changes in Self‐Reported Excessive Daytime Sleepiness Are Associated With 5‐Year All‐Cause Mortality Risk Among Veterans Open

Katherine G. Bay, Arash Maghsoudi, Amin Ramezani, Drew A. Helmer, Amir Sharafkhaneh , et al. · 2025

Excessive daytime sleepiness (EDS) is linked to adverse clinical outcomes. This study evaluated changes in a validated tool to assess EDS, the Epworth Sleepiness Scale (ESS) and mortality risk. This retrospective cohort study included Vete…

Virtual Pulmonary Rehabilitation in the United States: Clinical Practice Experience Open

Mon S. Bryant, Venkata Bandi, Shahram Moghtader, Amir Sharafkhaneh · 2025

Advancing Narcolepsy Advocacy: Bridging Patient Narratives and Systemic Change Open

Ahmed S. BaHammam, Lindsay Jesteadt, Hamza O. Dhafar, Amir Sharafkhaneh · 2025

We introduce the Stigma-to-Structure Advocacy Framework, a novel, evidence-based model designed to transform narcolepsy advocacy by systematically bridging patient narratives with structural change. Narcolepsy remains a profoundly underdia…

Identification of Frailty Clusters Using Cross-Sectional Frailty and Frailty Trajectory Open

Javad Razjouyan, Saeed Tofighi, Ariela R. Orkaby, Biykem Bozkurt, Amir Sharafkhaneh , et al. · 2025

Integrating cross-sectional FI and longitudinal FT offers a comprehensive assessment of frailty in HF patients, improving risk stratification and disease management.

0948 Total Sleep Time Modulates the Association Between Sleep Efficiency and Mortality: Insights from Big Data Open

Arash Maghsoudi, Amir Sharafkhaneh, Javad Razjouyan · 2025

Introduction Sleep efficiency (SE) and total sleep time (TST) are crucial parameters for sleep quality and quantity and affect health outcomes. Previous studies suggest an association between poor sleep metrics and increased mortality. Thi…

0455 Use of Natural Language Processing to Identify Patients with Diagnosis of Narcolepsy Open

Malihehsadat Chavooshi, Amin Ramezani, Shahram Moghtader, Amir Sharafkhaneh, Javad Razjouyan · 2025

Introduction Narcolepsy is a rare chronic neurological disorder that requires precise identification for timely diagnosis and intervention. It is undocumented or underdiagnosed in the electronic health records due to lack of standardized t…

0494 Age and Gender-Specific Associations Between Severe Sleep Apnea and All-Cause Mortality in Female Veterans: Insights from a Retrospective Cohort Study Open

Amin Ramezani, Mehrnaz Azarian, Arash Maghsoudi, Susan Redline, Thomas Penzel , et al. · 2025

Introduction Sleep apnea (SA) is a prevalent sleep disorder associated with increased health risks, including mortality. While previous studies largely focused on male populations, gender-specific associations remain underexplored. This st…

0667 Gender-Specific Insights: Association Between Sleep Apnea Severity and Mortality in Female Veterans, Accounting for Race, Ethnicity, and Age Open

Mehrnaz Azarian, Amin Ramezani, Arash Maghsoudi, Amir Sharafkhaneh, Javad Razjouyan · 2025

Introduction Our previous study in an overwhelmingly male population demonstrated a U-shaped relationship between sleep apnea (SA) and mortality, with mild to moderate SA associated with the lowest mortality risk. We aim to investigate the…

0893 Expert Annotation of Free-text Descriptions of Dream Enactment Behaviors Associated with REM Sleep Behavior Disorder Open

Melissa B. Jones, Arash Maghsoudi, Taryn White, Amir Sharafkhaneh, Javad Razjouyan , et al. · 2025

Introduction We developed a database of free-text descriptions of dream enactment behavior (DEBs) from unstructured clinical notes of Veterans with electronic diagnoses of rapid eye movement sleep behavior disorder (RBD). We additionally e…

0929 Excessive Daytime Sleepiness and All-Cause Mortality in Female Veterans: A Retrospective Cohort Analysis Open

Arash Maghsoudi, Kalli McWhinney, Mehrnaz Azarian, Amin Ramezani, Javad Razjouyan , et al. · 2025

Introduction Excessive Daytime Sleepiness (EDS) has been associated with all-cause mortality in previous studies, which primarily focused on male populations. This study aims to examine the presence of this relationship in a large cohort o…

0663 Mortality Associated with Sleep Apnea, Insomnia, and COMISA May Be Lower for Treated Racial and Ethnic Minoritized Veterans Open

Douglas M. Wallace, Alexander Sweetman, Luis F. Buenaver, Javad Razjouyan, Charles Crew , et al. · 2025

Introduction Few data exist exploring the relationship between treatment of sleep apnea (SA), insomnia, comorbid insomnia and sleep apnea (COMISA) with mortality among racial and ethnic minoritized (REM) US veterans receiving sleep care. W…

A clinical algorithm for diagnosis and treatment of insomnia in adults: an updated review Open

Habibolah Khazaie, Amir Sharafkhaneh, Ali Zakiei, Earl Charles Crew · 2024

Difficulty falling asleep and/or maintaining sleep are common complaints in patients visiting medical clinics. Insomnia can occur alone or in combination with other medical or psychiatric disorders. Diagnosis and management of insomnia at …

The Saga of COVID-19 in Chronic Lung Disease: History Repeats Itself Open

Amir Sharafkhaneh, Javad Razjouyan · 2024

Age modifies the association between severe sleep apnea and all-cause mortality Open

Amin Ramezani, Mehrnaz Azarian, Amir Sharafkhaneh, Arash Maghsoudi, Melissa B. Jones , et al. · 2024

Effects of COVID-19 on Sleep Services Use and Its Recovery Open

Amin Ramezani, Amir Sharafkhaneh, Ahmed S. BaHammam, Samuel T. Kuna, Javad Razjouyan · 2024

Sleep testing services utilization recovered differentially during the pandemic (PSG vs HSAT), including a surge in HSAT utilization post-vaccination.

Identification of sleep phenotypes in COPD using machine learning-based cluster analysis Open

Javad Razjouyan, Nicola A. Hanania, Sara Nowakowski, Ritwick Agrawal, Amir Sharafkhaneh · 2024

Validation of electronic diagnostic codes for rapid eye movement sleep behavior disorder Open

Melissa B. Jones, Carlos H. Schenck, Mehrnaz Azarian, Ricardo E. Jorge, Amir Sharafkhaneh , et al. · 2024

Identification of Sleep Phenotypes in COPD Using Machine Learning-Based Cluster Analysis Open

Javad Razjouyan, Nicola A. Hanania, Sara Nowakowski, Ritwick Agrawal, Amir Sharafkhaneh · 2024

A Comparative Machine Learning Analysis for Early Atrial Fibrillation Prediction Open

Badrosadat Nategholeslam Shirazi, Shiva Naghsh, Afsaneh Safavi, Amir Sharafkhaneh · 2024

Cardiovascular Diseases (CVD) are significant global cause of mortality. This paper focuses on early detection of a specific type of CVD, Atrial Fibrillation (AF), through a simple approach. The methodology is based on efficient risk asses…

Mortality Trends in Insomnia, Sleep Apnea and Comorbid Insomnia and Sleep Apnea (COMISA) Open

Javad Razjouyan, Alexander Sweetman, Earl Crew, Mehrnaz Azarian, Pegah Soltani , et al. · 2024

Risk of 30-Day All-Cause Readmission in Interstitial Lung Disease Patients after COVID-19: National-Level Data Open

Ali Vaeli Zadeh, Roshan Dinparastisaleh, Atefeh Vaezi, Debabrata Bandyopadhyay, Israel Rubinstein , et al. · 2023

Rationale: Hospital readmission within 30 days poses challenges for healthcare providers, policymakers, and patients because of its impact on care quality, costs, and outcomes. Patients with interstitial lung disease (ILD) are parti…

SWEET DREAMS INTERRUPTED: HOW COVID-19 CHANGED THE LANDSCAPE OF SLEEP SERVICES UTILIZATION ON AGING POPULATION Open

Javad Razjouyan, Samuel T. Kuna, Amir Sharafkhaneh · 2023

We evaluated the impact of the pandemic on sleep test utilization, i.e., home sleep apnea testing (HSAT) and in-laboratory polysomnography (PSG), among aging veterans. We conducted an observational before and during the pandemic study usin…

Pimavanserin 34 mg at Bedtime for the Treatment of Insomnia in 6 Veterans With Posttraumatic Stress Disorder Open

Melissa B. Jones, Ritwick Agrawal, Amir Sharafkhaneh, Gursimrat Bhatti, Ruosha Li , et al. · 2023

TRENDS IN SLEEP APNEA AND HEART FAILURE-RELATED MORTALITY IN THE UNITED STATES FROM 1999 TO 2019 Open

Aleezay Asghar, Khawaja M. Talha, Eisha Waqar, Laurence Sperling, Ernest DiNino , et al. · 2023

Obesity paradox or hypoxia preconditioning: How obstructive sleep apnea modifies the Obesity-MI relationship Open

Amir Sharafkhaneh, Ritwick Agrawal, Vijay Nambi, Ahmed S. BaHammam, Javad Razjouyan · 2023

0357 Pimavanserin 34mg at Bedtime for Insomnia in Veterans with Post-traumatic Stress Disorder: Open-label Case Series Open

Melissa B. Jones, Ritwick Agrawal, Amir Sharafkhaneh, Mohamed Elammari, Zhao Zhifang , et al. · 2023

Introduction There is a critical need for effective and feasible interventions to address insomnia associated with post-traumatic stress disorder (PTSD). Several lines of evidence suggest that pimavanserin, a 5-HT2A inverse agonist approve…

0495 Epworth Sleepiness Scale Worth for Sleep Apnea Screening: A Large Cohort of Polysomnographies via Natural Language Processing Open

Arash Maghsoudi, Sara Nowakowski, Mahbubur Rahman, Trung Nguyen, Ritwick Agrawal , et al. · 2023

Introduction Obstructive sleep apnea (OSA) is a major sleep disorder that presents with excessive daytime sleepiness (EDS). Epworth Sleepiness Scale (ESS) as a measure of EDS is used to monitor population sleep health. We aim to assess the…

Obstructive sleep apnea modulates clinical outcomes post-acute myocardial infarction: A large longitudinal veterans’ dataset report Open

Ritwick Agrawal, Amir Sharafkhaneh, Vijay Nambi, Ahmed S. BaHammam, Javad Razjouyan · 2023

Inflammatory Biomarkers Differ among Hospitalized Veterans Infected with Alpha, Delta, and Omicron SARS-CoV-2 Variants Open

Catherine Park, Shahriar Tavakoli–Tabasi, Amir Sharafkhaneh, Benjamin Seligman, Bret Hicken , et al. · 2023

Mortality due to COVID-19 has been correlated with laboratory markers of inflammation, such as C-reactive protein (CRP). The lower mortality during Omicron variant infections could be explained by variant-specific immune responses or host …

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