Amira A. H. Ali
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View article: Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice
Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice Open
Introduction Glutamate represents the dominant neurotransmitter that conveys the light information to the brain, including the suprachiasmatic nucleus (SCN), the central pacemaker for the circadian system. The neuronal and astrocytic gluta…
View article: Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus
Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus Open
Background: Chronic liver diseases such as hepatic tumors can affect the brain through the liver–brain axis, leading to neurotransmitter dysregulation and behavioral changes. Cancer patients suffer from fatigue, which can be associated wit…
View article: Timing of Deep and REM Sleep Based on Fitbit Sleep Staging in Young Healthy Adults under Real-Life Conditions
Timing of Deep and REM Sleep Based on Fitbit Sleep Staging in Young Healthy Adults under Real-Life Conditions Open
Sleep timing is controlled by intrinsic homeostatic and circadian components. The circadian component controls the chronotype, which is defined by the propensity to sleep at a particular clock time. However, sleep timing can be significant…
View article: Sexual Dimorphism of Dopaminergic Neurons and Microglia in The Basal Ganglia of Adult Mice
Sexual Dimorphism of Dopaminergic Neurons and Microglia in The Basal Ganglia of Adult Mice Open
View article: Anticonvulsant Luminal Affects the Arginine-Vasopressin Expression in Hypothalamus and the Locomotor Behaviour of Male Mice
Anticonvulsant Luminal Affects the Arginine-Vasopressin Expression in Hypothalamus and the Locomotor Behaviour of Male Mice Open
View article: Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus
Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus Open
Circadian rhythms in behavior and physiology such as rest/activity and hormones are driven by an internal clock and persist in the absence of rhythmic environmental cues. However, the period and phase of the internal clock are entrained by…
View article: Radiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus
Radiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus Open
Chronic liver diseases including hepatocellular carcinoma (HCC) create a state of chronic inflammation that affects the brain via the liver–brain axis leading to an alteration of neurotransmission and cognition. However, little is known ab…
View article: Neuroprotective and therapeutic effects of calcitriol in rotenone-induced Parkinson’s disease rat model
Neuroprotective and therapeutic effects of calcitriol in rotenone-induced Parkinson’s disease rat model Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Treatment of PD is challenging, as current treatment strategies are only symptomatic and do not stop disease development. Recent studies reported neuroprotective…
View article: Adult Neurogenesis under Control of the Circadian System
Adult Neurogenesis under Control of the Circadian System Open
The mammalian circadian system is a hierarchically organized system, which controls a 24-h periodicity in a wide variety of body and brain functions and physiological processes. There is increasing evidence that the circadian system modula…
View article: Does timing matter in radiotherapy of hepatocellular carcinoma? An experimental study in mice
Does timing matter in radiotherapy of hepatocellular carcinoma? An experimental study in mice Open
This study investigates whether a chronotherapeutic treatment of hepatocellular carcinoma (HCC) may improve treatment efficacy and mitigate side effects on non‐tumoral liver (NTL). HCC was induced in Per2 :: luc mice which were irradiated …
View article: Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus
Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus Open
ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and path…
View article: Citrus sinensis Extract as a Green Inhibitor for the Corrosion of Carbon Steel in Sulphuric Acid Solution
Citrus sinensis Extract as a Green Inhibitor for the Corrosion of Carbon Steel in Sulphuric Acid Solution Open
Citrus sinensis extract is considered a good inhibitor to protect the carbon steel in half of molar of sulfuric acid from corrosion, as it was found from the results of chemical methods such as the weight loss (ML) method and also from the…
View article: Does a Red House Affect Rhythms in Mice with a Corrupted Circadian System?
Does a Red House Affect Rhythms in Mice with a Corrupted Circadian System? Open
The circadian rhythms of body functions in mammals are controlled by the circadian system. The suprachiasmatic nucleus (SCN) in the hypothalamus orchestrates subordinate oscillators. Time information is conveyed from the retina to the SCN …
View article: Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model Open
Cancer‐related fatigue (CRF) and stress are common symptoms in cancer patients and represent early side effects of cancer treatment which affect the life quality of the patients. CRF may partly depend on disruption of the circadian rhythm.…
View article: Does Timing Matter in Radiotherapy of Hepatocellular Carcinoma?
Does Timing Matter in Radiotherapy of Hepatocellular Carcinoma? Open
This study investigates whether a chronotherapeutic treatment of hepatocellular carcinoma (HCC) may improve treatment efficacy and mitigate side effects on healthy liver (HL). HCC was induced in Per2::luc mice which were irradiated at four…
View article: The Role of Purinergic Receptors in the Circadian System
The Role of Purinergic Receptors in the Circadian System Open
The circadian system is an internal time-keeping system that synchronizes the behavior and physiology of an organism to the 24 h solar day. The master circadian clock, the suprachiasmatic nucleus (SCN), resides in the hypothalamus. It rece…
View article: Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function
Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function Open
The circadian system is an endogenous timekeeping system that synchronizes physiology and behavior with the 24 h solar day. Mice with total deletion of the core circadian clock gene Bmal1 show circadian arrhythmicity, cognitive deficits, a…
View article: Bmal1‐deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes
Bmal1‐deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes Open
Bmal1 is an essential component of the molecular clockwork, which drives circadian rhythms in cell function. In Bmal1‐deficient (Bmal1−/−) mice, chronodisruption is associated with cognitive deficits and progressive brain pathology includi…
View article: Connexin30 and Connexin43 show a time-of-day dependent expression in the mouse suprachiasmatic nucleus and modulate rhythmic locomotor activity in the context of chronodisruption
Connexin30 and Connexin43 show a time-of-day dependent expression in the mouse suprachiasmatic nucleus and modulate rhythmic locomotor activity in the context of chronodisruption Open
Circadian fluctuation of Cx30 and Cx43 protein expression in the SCN is differently regulated. Cx30 and astroglial Cx43 play a role in rhythm stability and re-entrainment under challenging conditions.
View article: Deficiency of the clock gene Bmal1 affects neural progenitor cell migration
Deficiency of the clock gene Bmal1 affects neural progenitor cell migration Open
View article: Sex-Dependent Effects of Bmal1-Deficiency on Mouse Cerebral Cortex Infarction in Response to Photothrombotic Stroke
Sex-Dependent Effects of Bmal1-Deficiency on Mouse Cerebral Cortex Infarction in Response to Photothrombotic Stroke Open
Stroke is a leading cause of disability and death worldwide. There is increasing evidence that occurrence of ischemic stroke is affected by circadian system and sex. However, little is known about the effect of these factors on structural …
View article: Time-of-day-dependent expression of purinergic receptors in mouse suprachiasmatic nucleus
Time-of-day-dependent expression of purinergic receptors in mouse suprachiasmatic nucleus Open
Purinergic P2X and P2Y receptors are involved in mediating intercellular signalling via purines such as adenosine triphosphate (ATP). P2X and P2Y receptors have been implicated in numerous body functions including learning, memory and slee…
View article: Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice
Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice Open
Hippocampal neurogenesis undergoes dramatic age-related changes. Mice with targeted deletion of the clock geneBmal1 (Bmal1(-/-)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cog…