Amira Abood
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View article: “Triazole-linked thiazolidinedione-Benzothiazole hybrids: Design and biological evaluation as AChE inhibitors”
“Triazole-linked thiazolidinedione-Benzothiazole hybrids: Design and biological evaluation as AChE inhibitors” Open
Novel 2,4-thiazolidinedione-benzothiazole-triazole hybrids (7a-7l) were designed and synthesized as therapeutic agents with pleotropic activity for Alzheimer's disease (AD). These compounds were evaluated for their acetylcholinesterase (AC…
View article: <i>Parascedosporium putredinis</i> NO1 tailors its secretome for different lignocellulosic substrates
<i>Parascedosporium putredinis</i> NO1 tailors its secretome for different lignocellulosic substrates Open
Parascedosporium putredinis NO1 is a plant biomass-degrading ascomycete with a propensity to target the most recalcitrant components of lignocellulose. Here we applied proteomics and activity-based protein profiling (ABPP) to investigate t…
View article: Identification of sulphonamide-tethered <i>N</i> -((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
Identification of sulphonamide-tethered <i>N</i> -((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease Open
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health and economy. Till producing successful vaccination strategies, the healthcare sectors suffered from the lack of effective therapeutic agents that could co…
View article: Recent Advances in Discovery, Biosynthesis and Therapeutic Potentialities of Isocoumarins Derived from Fungi: A Comprehensive Update
Recent Advances in Discovery, Biosynthesis and Therapeutic Potentialities of Isocoumarins Derived from Fungi: A Comprehensive Update Open
Microorganisms still remain as main hotspots in the global drug discovery avenue. In particular, fungi are highly prolific producers of a vast of structurally divers specialised secondary metabolites, which have displayed a myriad of biome…
View article: Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: a comprehensive update
Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: a comprehensive update Open
This review article provides an intensive state-of-the-art over the period 2000–2022 centred around the discovery, classifications, biosynthetic pathways and therapeutic potentialities of 351 structurally diverse fungal containing-isocouma…
View article: A multi-omics approach to lignocellulolytic enzyme discovery reveals a new ligninase activity from <i>Parascedosporium putredinis</i> NO1
A multi-omics approach to lignocellulolytic enzyme discovery reveals a new ligninase activity from <i>Parascedosporium putredinis</i> NO1 Open
Significance Lignocellulose, in the form of crop residues, presents an attractive alternative to crude oil for both the production of renewable fuels and chemicals. Its large-scale application as a feedstock, however, remains limited. A bo…
View article: CCDC 1951700: Experimental Crystal Structure Determination
CCDC 1951700: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …