Amira Adly
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View article: Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective
Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective Open
In general, a complete clinical and radiological assessment and some laboratory tests are indicated at the initial diagnosis to confirm a thrombotic disorder and to further choose the type of workup required. Future research should report …
View article: Probiotic Supplementation Improves Glucose Homeostasis and Modulates Interleukin (IL)-21 and IL-22 Levels in Pediatric Patients with Type 1 Diabetes: A Randomized Placebo-Controlled Trial
Probiotic Supplementation Improves Glucose Homeostasis and Modulates Interleukin (IL)-21 and IL-22 Levels in Pediatric Patients with Type 1 Diabetes: A Randomized Placebo-Controlled Trial Open
Background: Probiotics alter gut microbiota and have beneficial effects on immune homeostasis. The role of probiotics in diabetes has been shown in some studies. Interleukin (IL)-21 and IL-22 have been implicated in the pathogenesis of typ…
View article: A change in risk factors and prevalence of iron-deficiency anemia among Egyptian infants 6–24 months old in Cairo, compared to a decade ago
A change in risk factors and prevalence of iron-deficiency anemia among Egyptian infants 6–24 months old in Cairo, compared to a decade ago Open
Background Iron-deficiency anemia (IDA) is common among children aged 6–24 months, primarily due to inadequate iron intake. Since the publication of prevalence data on ID and IDA in 2012, changes in risk factors will be highlighted in this…
View article: Clinical validity of fluorescence-based devices versus visual-tactile method in detection of secondary caries around resin composite restorations: diagnostic accuracy study
Clinical validity of fluorescence-based devices versus visual-tactile method in detection of secondary caries around resin composite restorations: diagnostic accuracy study Open
View article: A 6‐month randomized controlled trial for vitamin E supplementation in pediatric patients with Gaucher disease: Effect on oxidative stress, disease severity and hepatic complications
A 6‐month randomized controlled trial for vitamin E supplementation in pediatric patients with Gaucher disease: Effect on oxidative stress, disease severity and hepatic complications Open
Enzymatic deficiency in Gaucher disease (GD) may induce oxidative stress. Vitamin E is the nature's most effective lipid‐soluble antioxidant. This prospective clinical trial assessed the oxidant‐antioxidant status in Egyptian patients with…
View article: Diagnosis and management of patients with Gaucher disease: an Egyptian expert opinion
Diagnosis and management of patients with Gaucher disease: an Egyptian expert opinion Open
Background Gaucher disease (GD), an autosomal recessive, lysosomal storage disorder, is caused due to mutations in the glucocerebrosidase ( GBA ) gene. GD can occur at any age and is classified as type 1 (non-neurologic), type 2 (infantile…
View article: Egyptian Pediatric Guidelines for the Management of Children with Isolated Thrombocytopenia Using the Adapted ADAPTE Methodology—A Limited-Resource Country Perspective
Egyptian Pediatric Guidelines for the Management of Children with Isolated Thrombocytopenia Using the Adapted ADAPTE Methodology—A Limited-Resource Country Perspective Open
Background: Thrombocytopenia is a prevalent presentation in childhood with a broad spectrum of etiologies, associated findings, and clinical outcomes. Establishing the cause of thrombocytopenia and its proper management have obvious clinic…
View article: Transfusion of blood components in pediatric age groups: an evidence-based clinical practice guideline adapted for the use in Egypt using ‘Adapted ADAPTE’
Transfusion of blood components in pediatric age groups: an evidence-based clinical practice guideline adapted for the use in Egypt using ‘Adapted ADAPTE’ Open
View article: Alarming signs of localized and generalized lymphadenopathy referred to two pediatric tertiary centers
Alarming signs of localized and generalized lymphadenopathy referred to two pediatric tertiary centers Open
Background Lymphadenopathy (LN) affects as many as 90% of young children. A common cause of cervical LN is viral agents. The second most common cause is bacterial infections. While cancer is the most feared cause of generalized LN [2]. Obj…
View article: ALL-036 Efficacy and Safety of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist in Children With Chemotherapy-Induced Hyperglycemia
ALL-036 Efficacy and Safety of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist in Children With Chemotherapy-Induced Hyperglycemia Open
View article: POSTER: ALL-036 Efficacy and Safety of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist in Children With Chemotherapy-Induced Hyperglycemia
POSTER: ALL-036 Efficacy and Safety of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist in Children With Chemotherapy-Induced Hyperglycemia Open
View article: ALL-020 Localized and Generalized Lymphadenopathy Referred to 3 Tertiary Pediatric Centers Over 6 Years: The Alarming Signs
ALL-020 Localized and Generalized Lymphadenopathy Referred to 3 Tertiary Pediatric Centers Over 6 Years: The Alarming Signs Open
View article: PB2493: PERIPHERAL NEUROPATHY A HIDDEN CAUSE FOR PAIN IN GAUCHER DISEASE.A CASE REPORT AND REVIEW OF LITERATURE
PB2493: PERIPHERAL NEUROPATHY A HIDDEN CAUSE FOR PAIN IN GAUCHER DISEASE.A CASE REPORT AND REVIEW OF LITERATURE Open
Topic: 23. Hematopoiesis, stem cells and microenvironment Background: Pain is one of the disabling symptom in Gaucher disease, many studies investigated its etiology especially in Gaucher disease type 1.Peripheral neuropathy is a well esta…
View article: P1462: NEUROCOGNITIVE FUNCTION AND PSYCHOLOGICAL ASSESSMENT IN TRANSFUSION-DEPENDENT BETA-THALASSEMIA PATIENTS: RELATION TO BRAIN IRON CONTENT
P1462: NEUROCOGNITIVE FUNCTION AND PSYCHOLOGICAL ASSESSMENT IN TRANSFUSION-DEPENDENT BETA-THALASSEMIA PATIENTS: RELATION TO BRAIN IRON CONTENT Open
Topic: 27. Thalassemias Background: Neurological complications in β-thalassemia patients remain subclinical and detected only during neuroimaging evaluation. Cognitive impairment, abnormal findings on evoked potentials and cerebrovascular …
View article: Efficacy and safety of early‐start deferiprone in infants and young children with transfusion‐dependent beta thalassemia: Evidence for iron shuttling to transferrin in a randomized, double‐blind, placebo‐controlled, clinical trial (<scp>START</scp>)
Efficacy and safety of early‐start deferiprone in infants and young children with transfusion‐dependent beta thalassemia: Evidence for iron shuttling to transferrin in a randomized, double‐blind, placebo‐controlled, clinical trial (<span>START</span>) Open
Children with transfusion‐dependent thalassemia (TDT) require regular blood transfusions that, without iron‐chelation therapy, lead to iron‐overload toxicities. Current practice delays chelation therapy (late‐start) until reaching iron ove…
View article: New nutritional challenge in glucose-6-phosphate dehydrogenase-deficient patients: Prospective study with genotype–phenotype correlation
New nutritional challenge in glucose-6-phosphate dehydrogenase-deficient patients: Prospective study with genotype–phenotype correlation Open
Objectives Glucose-6-phosphate dehydrogenase (G6PD) deficiency adds a burden on patients and their families in Egypt and Middle East due to lifelong diet restriction. Thus, the current study aimed to investigate the challenge with non-fava…
View article: Deferiprone for transfusional iron overload in sickle cell disease and other anemias: open-label study of up to 3 years
Deferiprone for transfusional iron overload in sickle cell disease and other anemias: open-label study of up to 3 years Open
Long-term safety and efficacy data on the iron chelator deferiprone in sickle cell disease (SCD) and other anemias are limited. FIRST-EXT was a 2-year extension study of FIRST (Ferriprox in Patients With Iron Overload in Sickle Cell Diseas…
View article: S123: SAFETY AND EFFICACY OF EARLY-START DEFERIPRONE IN INFANTS AND YOUNG CHILDREN WITH BETA-THALASSEMIA (START STUDY)
S123: SAFETY AND EFFICACY OF EARLY-START DEFERIPRONE IN INFANTS AND YOUNG CHILDREN WITH BETA-THALASSEMIA (START STUDY) Open
Background: Patients with beta-thalassemia may need regular red blood cell transfusions in infancy.1 In the absence of iron chelation therapy, frequent transfusions cause iron to accumulate, which can lead to morbidity, organ damage, and d…
View article: Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study
Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study Open
Many people with sickle cell disease (SCD) or other anemias require chronic blood transfusions, which often causes iron overload that requires chelation therapy. The iron chelator deferiprone is frequently used in individuals with thalasse…
View article: Poster: ALL-098: COVID-19 in Children with Cancer: What We Learned from the First Wave
Poster: ALL-098: COVID-19 in Children with Cancer: What We Learned from the First Wave Open
View article: ALL-098: COVID-19 in Children with Cancer: What We Learned from the First Wave
ALL-098: COVID-19 in Children with Cancer: What We Learned from the First Wave Open
View article: Management of children with <scp>glucose‐6‐phosphate</scp> dehydrogenase deficiency presenting with acute haemolytic crisis during the <scp>SARs‐COV</scp>‐2 pandemic
Management of children with <span>glucose‐6‐phosphate</span> dehydrogenase deficiency presenting with acute haemolytic crisis during the <span>SARs‐COV</span>‐2 pandemic Open
Background and Objectives Shortage of blood during the severe acute respiratory syndrome‐COV‐2 (SARs‐COV‐2) pandemic impacted transfusion practice. The primary aim of the study is to assess management of acute haemolytic crisis (AHC) in gl…
View article: Significance and relation of vitamin D levels in head and neck cancers
Significance and relation of vitamin D levels in head and neck cancers Open
Background Vitamin D and its metabolites reduce the incidence of various cancers including head and neck SCC by inhibiting tumor angiogenesis, stimulating mutual adherence of cells, and enhancing intercellular communication, thereby streng…
View article: Predictors of future microalbuminuria in children and adolescents with type 1 diabetes mellitus in Egypt
Predictors of future microalbuminuria in children and adolescents with type 1 diabetes mellitus in Egypt Open
Introduction The present study was designed to assess the validity and efficacy of urinary markers (NAG, RBP, transferrin, α1-microglobulin, and plasma homocysteine) as early predictors of microalbuminuria in diabetic nephropathy in childr…
View article: PB2316 EFFECT OF VITAMIN D SUPPLEMENTATION ON CLINICAL OUTCOMES OF SICKLE CELL DISEASE
PB2316 EFFECT OF VITAMIN D SUPPLEMENTATION ON CLINICAL OUTCOMES OF SICKLE CELL DISEASE Open
Background: Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathy. Vitamin D deficiency has emerged as a public health focus in recent years and it is one of the most common nutritional conditions among persons wi…
View article: PS1570 PENTRAXIN-3 LEVEL AS A NOVEL VASCULAR ENDOTHELIAL MARKER IN NEWLY DIAGNOSED AND MULTI-TRANSFUSED PATIENTS WITH B-THALASSEMIA MAJOR: RELATION TO OXIDATIVE STRESS AND SUB-CLINICAL ATHEROSCLEROSIS
PS1570 PENTRAXIN-3 LEVEL AS A NOVEL VASCULAR ENDOTHELIAL MARKER IN NEWLY DIAGNOSED AND MULTI-TRANSFUSED PATIENTS WITH B-THALASSEMIA MAJOR: RELATION TO OXIDATIVE STRESS AND SUB-CLINICAL ATHEROSCLEROSIS Open
Background: It is suggested that PTX-3 increases oxidant stress and can be used as an early diagnostic marker for inflammation. PTX3 is a sensitive and specific biomarker for the diagnosis of cardiovascular diseases such as acute coronary …
View article: PS1486 INTERLEUKIN‐33 IN PEDIATRIC PATIENTS WITH IMMUNE THROMBOCYTOPENIA: RELATION TO PROGNOSIS AND TREATMENT OUTCOME
PS1486 INTERLEUKIN‐33 IN PEDIATRIC PATIENTS WITH IMMUNE THROMBOCYTOPENIA: RELATION TO PROGNOSIS AND TREATMENT OUTCOME Open
Background: The pathogenesis of thrombocytopenia in immune thrombocytopenia (ITP) has shifted from the traditional view of increased platelet destruction mediated by autoantibodies to more complex mechanisms where both impaired platelet pr…
View article: PB2390 THE ROLE OF T REGULATORY CELLS IN THE PATHOGENS AND IMMUNITY OF BETA‐THALASSEMIA MAJOR PATIENTS
PB2390 THE ROLE OF T REGULATORY CELLS IN THE PATHOGENS AND IMMUNITY OF BETA‐THALASSEMIA MAJOR PATIENTS Open
Background: The basis of the pathogenesis of the immunodeficiency in thalassemia is iron overload and allogenic stimulation caused by multiple blood transfusions. T regulatory cells (Tregs) are a component of the immune system that constit…
View article: Evaluation of continuous glucose monitoring system for detection of alterations in glucose homeostasis in pediatric patients with β-thalassemia major
Evaluation of continuous glucose monitoring system for detection of alterations in glucose homeostasis in pediatric patients with β-thalassemia major Open
The use of CGMS in the diagnosis of early glycemic abnormalities among pediatric patients with β-TM appears to be superior to other known diagnostic modalities.
View article: Safety and efficacy of early start of iron chelation therapy with deferiprone in young children newly diagnosed with transfusion‐dependent thalassemia: A randomized controlled trial
Safety and efficacy of early start of iron chelation therapy with deferiprone in young children newly diagnosed with transfusion‐dependent thalassemia: A randomized controlled trial Open
Iron overload is inevitable in patients who are transfusion dependent. In young children with transfusion‐dependent thalassemia (TDT), current practice is to delay the start of iron chelation therapy due to concerns over toxicities, which …