Amira E. M. Abdallah
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View article: Multicomponent reactions of cyanoacetanilide derivatives: Synthesis of coumarin and quinoline derivative and evaluations of their cytotoxicity
Multicomponent reactions of cyanoacetanilide derivatives: Synthesis of coumarin and quinoline derivative and evaluations of their cytotoxicity Open
In this study, several fused heterocyclic systems involving tetrahydrobenzopyrans 7a-i and tetrahydrobenzopyridines 9a-i were synthesized. The reactions proceed via a multicomponent reaction of different aromatic aldehydes, cyanoacetanilid…
View article: Pyrimidine-5-carbonitrile derivatives as sprout for CQDs proveniences: Antitumor and anti-inflammatory potentiality
Pyrimidine-5-carbonitrile derivatives as sprout for CQDs proveniences: Antitumor and anti-inflammatory potentiality Open
A comparative study is proposed to show the effect of variation in the heteroatoms in the main skeleton of CQDs proveniences, on their affinity for nucleation of CQDs, as anti-inflammatory and anticancer drugs. Heterocyclic-based CQDs spro…
View article: Multi-component synthesis of pyrazolo[1,5-a]quinazoline, thiazole and thiophene derivatives as cytotoxic agents
Multi-component synthesis of pyrazolo[1,5-a]quinazoline, thiazole and thiophene derivatives as cytotoxic agents Open
This study demonstrated the synthesis of a number of pyrazolo[1,5-a]quinazoline derivatives about 24 products based on the starting material 4-(2-phenylhydrazono)-4H-pyrazol-3-amine derivatives 1a-f. Moreover, other ring systems including …
View article: Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity
Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity Open
Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as re…
View article: Novel Fluorescent Benzothiazolyl-Coumarin Hybrids as Anti-SARS-COVID-2 Agents Supported by Molecular Docking Studies: Design, Synthesis, X-ray Crystal Structures, DFT, and TD-DFT/PCM Calculations
Novel Fluorescent Benzothiazolyl-Coumarin Hybrids as Anti-SARS-COVID-2 Agents Supported by Molecular Docking Studies: Design, Synthesis, X-ray Crystal Structures, DFT, and TD-DFT/PCM Calculations Open
This study revealed the design and preparation of new 3-(benzo[d]thiazol-2-yl)-2H-chromen-2-one derivatives 9a-h. The structures of the synthesized products were elucidated by their spectroscopic data and X-ray crystallography for compound…
View article: Crystal structure of 3-(benzo[<i>d</i>]thiazol-2-yl)-6-methyl-2<i>H</i>-chromen-2-one
Crystal structure of 3-(benzo[<i>d</i>]thiazol-2-yl)-6-methyl-2<i>H</i>-chromen-2-one Open
The molecule of the title compound, C 17 H 11 NO 2 S, is almost planar, with an interplanar angle of 3.01 (3)° between the benzothiazole and chromene ring systems. A short intramolecular S...O=C contact of 2.727 (2) Å is observed. The crys…
View article: Crystal structure of <i>N</i>-[3-(benzo[<i>d</i>]thiazol-2-yl)-6-bromo-2<i>H</i>-chromen-2-ylidene]-4-methylbenzenamine
Crystal structure of <i>N</i>-[3-(benzo[<i>d</i>]thiazol-2-yl)-6-bromo-2<i>H</i>-chromen-2-ylidene]-4-methylbenzenamine Open
The title compound, C 23 H 15 BrN 2 OS, was the unexpected product in an attempted synthesis of the isomeric 3-(benzo[ d ]thiazol-2-yl)-6-bromo-1- p -tolylquinolin-2(1 H )-one. The C chromene =N—C angle is wide [125.28 (8)°]. The benzothia…
View article: Multi-component reactions for the synthesis of pyrazolo [1,5-a]quinoline derivatives together with their cytotoxic evaluations
Multi-component reactions for the synthesis of pyrazolo [1,5-a]quinoline derivatives together with their cytotoxic evaluations Open
A new approaches for the synthesis of novel pyrazolo[1,5-a]quinazoline 8a-f and pyrazolo[1,5-a]quinazolin-6-one 10a-s and 12a-s derivatives were obtained using 4-(2-phenylhydrazono)-4H-pyrazol-3-amine derivatives 5a-f via their multi-compo…
View article: 3-(Benzo[<i>d</i>]thiazol-2-yl)-2<i>H</i>-chromen-2-one
3-(Benzo[<i>d</i>]thiazol-2-yl)-2<i>H</i>-chromen-2-one Open
In the title compound, C 16 H 9 NO 2 S, the interplanar angle is 6.47 (6)°. An intramolecular S...O=C contact of 2.727 (2) Å is observed. The packing is determined by several types of weak interaction (`weak' hydrogen bonds, S...S contacts…
View article: Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine
Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine Open
Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied. The structure of the newly synthesized compounds was establi…
View article: Synthesis, Docking and Antimicrobials Evaluation of Novel Pyrazolotriazines as RNA Polymerase Inhibitors
Synthesis, Docking and Antimicrobials Evaluation of Novel Pyrazolotriazines as RNA Polymerase Inhibitors Open
Aims: Producing novel pyrazolotriazines such as pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[5,1-c][1,2,4]triazine derivatives and evaluate their biological activity as antimicrobial agents followed by the Minimum Inhibitory Concentration (…
View article: Novel Homo-and Co-polymers Based on 7-Methacryloyloxy-4-methylcoumarin: Synthesis, Antimicrobial Activity, Pour-Point Depressants and Their Effects on the Rheology of the Waxy Crude Oil
Novel Homo-and Co-polymers Based on 7-Methacryloyloxy-4-methylcoumarin: Synthesis, Antimicrobial Activity, Pour-Point Depressants and Their Effects on the Rheology of the Waxy Crude Oil Open
This study aimed to synthesize new polymeric additives including homo- and co-polymers based on 4-methyl-2-oxo-2H-chromen-7-yl methacrylate monomer and evaluating their activity as potential antimicrobials and as pour-point depressants for…
View article: Novel Melatonin Derivatives: Synthesis, Anticancer Evaluations and Molecular-Docking Study
Novel Melatonin Derivatives: Synthesis, Anticancer Evaluations and Molecular-Docking Study Open
Many studies mentioned that Melatonin considers an anti-cancer agent. So in this study, a lot of novel Melatonin derivatives incorporated different heterocyclic ring systems such as triazole, thiadiazole, tetrazole, thiazole, thiophene and…
View article: Synthesis of Thiophenyl, Thiazolyl, and Pyridinyl Androstane Derivatives: A Novel Class of Potent Anti-inflammatory and Anti-ulcerogenic Heterocyclic Steroids
Synthesis of Thiophenyl, Thiazolyl, and Pyridinyl Androstane Derivatives: A Novel Class of Potent Anti-inflammatory and Anti-ulcerogenic Heterocyclic Steroids Open
The investigation of drugs used for the treatment of inflammatory diseases with limited side effects becomes an urgent need for inflammation patients.This search aimed at the preparation of novel hybrid heterosteroids with structures espec…
View article: <p>Pyridine azo disperse dye derivatives and their selenium nanoparticles (SeNPs): synthesis, fastness properties, and antimicrobial evaluations</p>
Pyridine azo disperse dye derivatives and their selenium nanoparticles (SeNPs): synthesis, fastness properties, and antimicrobial evaluations Open
Finally, all the (SeNPs) compounds revealed higher activity against bacterial and fungal strains than the other synthesized compounds.
View article: Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-<em>a</em>]pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs
Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-<em>a</em>]pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs Open
About twenty two novel pyrazolo[1,5-a]pyrimidine derivatives and their corresponding cycloalkane ring-fused derivatives were prepared through the reaction of 5-aminopyrazoles 2 with different sodium salts of (hydroxymethylene) cycloalkanon…
View article: Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile
Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile Open
Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo…
View article: Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents
Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents Open
Attempting to produce cyclized systems with potential anti-proliferative activity, a series of novel thiophene and benzothiophene derivatives were designed and synthesized. The reactivity of the latter derivatives towards different chemica…