AmirAli Toghani
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View article: The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in <i>Nicotiana benthamiana prf</i> mutants
The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in <i>Nicotiana benthamiana prf</i> mutants Open
Nucleotide-binding and leucine-rich repeat immune receptors of the NRC clade act in one direction, with autoactive helpers able to trigger hypersensitive cell death without their sensor partners.
View article: A conserved small RNA-generating gene cluster undergoes sequence diversification and contributes to plant immunity
A conserved small RNA-generating gene cluster undergoes sequence diversification and contributes to plant immunity Open
Small RNA-mediated gene silencing contributes to plant immunity. The secondary small interfering RNA (siRNA) pathway promotes defense by silencing target genes in invading fungal and oomycete pathogens. Many secondary siRNAs derive from tr…
View article: Can <scp>AI</scp> modeling of protein structures distinguish between sensor and helper <scp>NLR</scp> immune receptors?
Can <span>AI</span> modeling of protein structures distinguish between sensor and helper <span>NLR</span> immune receptors? Open
View article: An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity
An effector from the potato late blight pathogen bridges ENTH-domain protein TOL9a to an activated helper NLR to suppress immunity Open
Pathogens counteract central nodes of NLR immune receptor networks to suppress immunity. However, the mechanisms by which pathogens hijack helper NLR pathways are poorly understood. Here, we show that an effector from the potato late bligh…
View article: A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes
A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes Open
Plant nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) confer disease resistance to many foliar and root parasites. However, the extent to which NLR-mediated immunity is differentially regulated between plant organ…
View article: Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector
Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector Open
Parasites can counteract host immunity by suppressing nucleotide binding and leucine-rich repeat (NLR) proteins that function as immune receptors. We previously showed that a cyst nematode virulence effector SPRYSEC15 (SS15) binds and inhi…
View article: The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in<i>prf</i>mutants of<i>Nicotiana benthamiana</i>
The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in<i>prf</i>mutants of<i>Nicotiana benthamiana</i> Open
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) can function in networks of sensors and helpers to induce hypersensitive cell death and immunity against pathogens. The tomato sensor NLR Prf guards the Pto kinase f…
View article: A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs
A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs Open
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) are known for their rapid evolution, even at the intraspecific level, yet the rates of evolution differ significantly across various NLR classes. Within the NRC (NLR…
View article: Can AI Modelling of Protein Structures Distinguish Between Sensor and Helper NLR Immune Receptors?
Can AI Modelling of Protein Structures Distinguish Between Sensor and Helper NLR Immune Receptors? Open
NLR immune receptors can be functionally organized in genetically linked sensor-helper pairs. However, methods to categorize paired NLRs remain limited, primarily relying on the presence of non-canonical domains in some sensor NLRs. Here, …
View article: Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors?
Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors? Open
NLR immune receptors can be functionally organized in genetically linked sensor-helper pairs. However, methods to categorize paired NLRs remain limited, primarily relying on the presence of non-canonical domains in some sensor NLRs. Here, …
View article: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity
A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity Open
NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute immune responses triggered by sensor NLRs. The resting state of NbNRC2 was recently shown to be a homodimer, but the sensor-activated s…
View article: Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome
Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome Open
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins can engage in complex interactions to detect pathogens and execute a robust immune response via downstream helper NLRs. However, the biochemical mechanisms of helper NLR acti…
View article: Subfunctionalization of NRC3 altered the genetic structure of the Nicotiana NRC network
Subfunctionalization of NRC3 altered the genetic structure of the Nicotiana NRC network Open
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins play crucial roles in immunity against pathogens in both animals and plants. In solanaceous plants, activation of several sensor NLRs triggers their helper NLRs, known as NLR…
View article: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity
A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity Open
NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute the immune response triggered by disease resistance proteins, also known as sensor NLRs. The structure of the resting state of NbNRC2 w…
View article: Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector
Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector Open
Parasites can counteract host immunity by suppressing nucleotide binding and leucine-rich repeat (NLR) proteins that function as immune receptors. We previously showed that a cyst nematode virulence effector SPRYSEC15 (SS15) binds and inhi…
View article: Phylogenomics of Plant NLR Immune Receptors to Identify Functionally Conserved Sequence Motifs
Phylogenomics of Plant NLR Immune Receptors to Identify Functionally Conserved Sequence Motifs Open
In recent years, the increase in genome sequencing across diverse plant species has provided a significant advantage for phylogenomics studies, allowing the analysis of one of the most diverse gene families in plants: nucleotide-binding le…
View article: Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome
Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome Open
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins can engage in complex interactions to detect pathogens and execute a robust immune response via downstream helper NLRs. However, the biochemical mechanisms of helper NLR acti…
View article: A root-specific NLR network confers resistance to plant parasitic nematodes - genomic sequences and annotations
A root-specific NLR network confers resistance to plant parasitic nematodes - genomic sequences and annotations Open
Sequence and annotation data associated with "A root-specific NLR network confers resistance to plant parasitic nematodes"
View article: A root-specific NLR network confers resistance to plant parasitic nematodes - genomic sequences and annotations
A root-specific NLR network confers resistance to plant parasitic nematodes - genomic sequences and annotations Open
Sequence and annotation data associated with "A root-specific NLR network confers resistance to plant parasitic nematodes"
View article: A root-specific NLR network confers resistance to plant parasitic nematodes
A root-specific NLR network confers resistance to plant parasitic nematodes Open
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) confer disease resistance to a multitude of foliar and root parasites of plants. However, the extent to which NLR immunity is expressed differentially between plant …
View article: Functional divergence shaped the network architecture of plant immune receptors
Functional divergence shaped the network architecture of plant immune receptors Open
In solanaceous plants, several sensor NLRs and their helper NLRs, known as NRC, form a complex network to confer immunity against pathogens. While the sensor NLRs and downstream NRC helpers display diverse genetic compatibility, the evolut…
View article: NLRome dataset from 124 genomes of plants in the Solanaceae family
NLRome dataset from 124 genomes of plants in the Solanaceae family Open
We report a dataset of 66,665 NLR immune receptor sequences extracted using NLRtracker from the proteomes of 124 genomes of plants in the Solanaceae family. These include samples from the following genera: Solanum (108 genomes, 30 species)…
View article: NLRome dataset from 124 genomes of plants in the Solanaceae family
NLRome dataset from 124 genomes of plants in the Solanaceae family Open
We report a dataset of 66,665 NLR immune receptor sequences extracted using NLRtracker from the proteomes of 124 genomes of plants in the Solanaceae family. These include samples from the following genera: Solanum (108 genomes, 30 species)…
View article: Dataset for the ancestral sequence reconstruction of NRC3
Dataset for the ancestral sequence reconstruction of NRC3 Open
Please refer to the material_and_method.pdf to check how we generated each file. 01_NRCH_cds_23-03-03.fasta FASTA file containing the nucleotide sequences of 2341 NRC helper sequences extracted from 124 Solanaceae NLRome dataset [1] and 20…
View article: Dataset for the ancestral sequence reconstruction of NRC3
Dataset for the ancestral sequence reconstruction of NRC3 Open
Please refer to the material_and_method.pdf to check how we generated each file. 01_NRCH_cds_23-03-03.fasta FASTA file containing the nucleotide sequences of 2341 NRC helper sequences extracted from 124 Solanaceae NLRome dataset [1] and 20…
View article: NLR receptors in plant immunity: making sense of the alphabet soup
NLR receptors in plant immunity: making sense of the alphabet soup Open
Plants coordinately use cell‐surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding and…
View article: NLR receptors in plant immunity: making sense of the alphabet soup
NLR receptors in plant immunity: making sense of the alphabet soup Open
Plants co-ordinately use cell-surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding an…
View article: Resurrection of plant disease resistance proteins via helper NLR bioengineering
Resurrection of plant disease resistance proteins via helper NLR bioengineering Open
Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich repeat (NLR) proteins that function as central nodes in immune receptor networks. Understanding the mechanisms of immunosuppression can lead to st…
View article: An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana
An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana Open
The NRC immune receptor network has evolved in asterid plants from a pair of linked genes into a genetically dispersed and phylogenetically structured network of sensor and helper NLR (nucleotide-binding domain and leucine-rich repeat-cont…
View article: Resurrection of plant disease resistance proteins via helper NLR bioengineering
Resurrection of plant disease resistance proteins via helper NLR bioengineering Open
Parasites counteract host immunity by suppressing helper NLR proteins that function as central nodes in immune receptor networks. Understanding the mechanisms of immunosuppression can lead to strategies for bioengineering disease resistanc…