Explanipedia

Folic Acid-Chitosan Conjugated Mesoporous Silica Nanoparticles for Enhanced Piceatannol Uptake in MCF-7 Breast Cancer Cells Open

Santosh Sarnaik, Hafiz Ahmed, Nazir Hussain, Sourav Kundu, Bidya Dhar Sahu , et al. · 2025

Targeted drug delivery using nanoparticle-based systems offers a promising strategy for improving breast cancer therapy. Mesoporous silica nanoparticles (MSNs) are attractive carriers due to their stability and ease of surface modification…

Phytochemical, Nutritional, Anti-Nutritional Evaluation and Antimicrobial Analysis of Pleurotus Ostreatus from Oshogbo in Osun State, Nigeria Open

Mumraiz Khan, Izuagbe Gilbert Osigbemhe, Y. Sikiratu, I.N. Oyeza, K. O. Adebayo , et al. · 2025

The study was carried out to determine the nutritional constituents, anti-nutritional composition, antimicrobial activity and phytochemical composition of Pleurotus ostreatus. Samples were determined in triplicates to ascertain the nutriti…

Polyethylene Glycol-Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery Open

Vinay Sagar Verma, Aakansha Pandey, Arvind Kumar Jha, Hemant Kumar Ramchandra Badwaik, Amit Alexander , et al. · 2023

Due to their potential to enhance therapeutic results and enable targeted drug administration, polymer-drug conjugates that use polyethylene glycol (PEG) as both the polymer and the linker for drug conjugation have attracted much research.…

Burn assessment: A critical review on care, advances in burn healing and pre-clinical animal studies Open

Ravish J. Patel, R. Desai, Amit A. Patel, Shailvi Shah, Bhupendra G. Prajapati , et al. · 2023

Burn, a severe skin injury due to electricity, radiation, chemicals, or friction, may lead to the death of affected skin cells.Burns are a painful and crucial problem which causes disabilities.Sometimes, burns may also associate with the m…

Nutraceutical prospects of Houttuynia cordata against the infectious viruses Open

Aparajita Ghosh, Bijoyani Ghosh, Nidhi Parihar, Myrthong Ilaweibaphyrnai, Samir Ranjan Panda , et al. · 2022

Insight and Perspective on Omicron’s Development, Behaviour, and Vaccine Breakthrough: Next Sequelae of COVID-19 Open

Krishna Yadav, Deependra Singh, Manju Rawat Singh, Ajazuddin Ajazuddin, Amit Alexander , et al. · 2022

: Background: The Severe Acute Respiratory Coronavirus (SARS-CoV-2) has emerged in a variety of forms since its first appearance in early December 2019. The Omicron variation (B.1.1.529) was recently confirmed as a relatively new Variant o…

Molecular docking for rationalizing the use of linkers in polymer drug conjugates design for pegylated anti-inflammatory drug delivery Open

Vinay Sagar Verma, A. N. Mishra, Hemant Badwaik, Amit Alexander, Ajazuddin Ajazuddin · 2022

A smart linker is a crucial element throughout the creation of polymer-drug conjugates. It binds different portions or subunits altogether and may be freed by a suitable trigger, resulting in localized drug distribution and enhanced bioava…

Statistical optimization of oxidative derivatization of polyethylene glycol to polyethylene carboxylate using custom design approach Open

Vinay Sagar Verma, Harsh Kumar Jain, Hemant Kumar Ramchandra Badwaik, Amit Alexander, M. Ajazuddin · 2022

Reaction optimization has been a tedious task for the research chemist for very long and many approaches has been employed to achieve the best reaction condition resulting in highest yield. As an answer to this problem the statistical opti…

PCL-PEG copolymer based injectable thermosensitive hydrogels Open

Mithun Rajendra Dethe, A Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy , et al. · 2022

Respiratory technologists in the frontlines against COVID-19. Open

S D Maasdorp, M Pretorius, P Pienaar, E Rosslee, Amit Alexander , et al. · 2022

The clinical characteristics and mortality of patients whose oxygen support was managed by respiratory technologists were similar to those in previously reported studies from resource-limited settings. Respiratory technologists can form a …

Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations Open

Neha Dabholkar, Srividya Gorantla, Sunil Kumar Dubey, Amit Alexander, Rajeev Taliyan , et al. · 2021

Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design Open

Mukta Agrawal, Shailendra Saraf, Madhulika Pradhan, Ravish J. Patel, Gautam Singhvi , et al. · 2021

In-line treatments and clinical initiatives to fight against COVID-19 outbreak Open

Mukta Agrawal, Shailendra Saraf, Swarnlata Saraf, Upadhyayula Suryanarayana Murty, Sucheta Banerjee Kurundkar , et al. · 2020

Virology, pathogenesis, diagnosis and in-line treatment of COVID-19 Open

Pavan Kumar Samudrala, Pramod Kumar, Kamlesh Choudhary, Nagender Thakur, Gaurav Suresh Wadekar , et al. · 2020

Recent expansions of novel strategies towards the drug targeting into the brain Open

Amit Alexander, Mukta Agrawal, A. N. M. Shofi Uddin, Sabahuddin Siddique, Ahmed M. Shehata , et al. · 2019

The treatment of central nervous system (CNS) disorders always remains a challenge for the researchers. The presence of various physiological barriers, primarily the blood-brain barrier (BBB) limits the accessibility of the brain and hinde…

Recent expansions of novel strategies towards the drug targeting into the brain Open

Amit Alexander, Mukta Agrawal, Aaliya Uddin, Soryia Siddique, Shehata AM , et al. · 2019

Amit Alexander,1 Mukta Agrawal,1 Ajaz Uddin,1 Sabahuddin Siddique,2 Ahmed M Shehata,3,4 Mahmoud A Shaker,5,6 Syed Ata Ur Rahman,7 Mohi Iqbal M Abdul,3 Mohamed A Shaker6,71Department of Pharmaceutics, Rungta College of Pharmaceutical Scienc…

Recent Expansions on Cellular Models to Uncover the Scientific Barriers Towards Drug Development for Alzheimer’s Disease Open

Sunil Kumar Dubey, Siva Ram Munnangi, Kowthavarapu Venkata Krishna, Ranendra Narayan Saha, Gautam Singhvi , et al. · 2019

Development and Validation of a Robust RP-HPLC Method for Analysis of Calcipotriol in Pharmaceutical Dosage Form Open

Madhulika Pradhan, Amit Alexander, M. Ajazuddin · 2019

Calcipotriol is a very efficient drug used in the treatment of psoriasis. In present work a novel, hasty, effortless and cost-effective Reversed -Phase High-Performance Thin-Layer Chromatography (RP-HPTLC) technique has been developed and …

Biomedical applications of microemulsion through dermal and transdermal route Open

Tripti Shukla, Neeraj Upmanyu, Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf , et al. · 2018

Microemulsions are thermodynamically stable, transparent, colloidal drug carrier system extensively used by the scientists for effective drug delivery across the skin. It is a spontaneous isotropic mixture of lipophilic and hydrophilic sub…

Understanding the Concept of Mucoadhesive Drug Delivery System: A Novel Approach over Conventional Dosage Forms Open

Umesh Kumar, Khuman Lal, Navneet Patel, Lekhraj, Jai Prakash , et al. · 2018

Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be d…

Formulation and Evaluation of Risperidone Loaded Mouth-Dissolving Film Open

Hemlata Sahu, Amit Alexander, Swapnil Gupta, Pooja Yadav, Hemlata Thapa , et al. · 2018

Mouth dissolving oral films are useful in patients such as paediatric, geriatric, bedridden or developmentally disabled who face difficulty in swallowing conventional tablets or capsules and liquid orals or syrups leading to ineffective th…

Formulation and evaluation of orodispersible tablet of montelukast sodium Open

Siddharth Kumar Sahu, M. Ajazuddin, Tripti Banjare, Swapnil Gupta, Akansha Bhandarkar , et al. · 2018

The objective of the current study was to develop and optimize an orodispersible tablet formulation of montelukast sodium which is an effective drug in the treatment of asthma and allergic disorders. Montelukast sodium is the drug used in …

A Review on Biocompatible Hydrogel: Formulation Aspect and Evaluation Open

Shubham Tripathi, Somnath Patel, R. R. Patel, Shraddha, Pushpendra Pushpendra , et al. · 2018

Many predefined ways are now a day adopted to interface with biological tissues. One such significant class of biomaterials are hydrogels, which are defined as highly hydrated materials. Hydrogels are designed to absorb a large amount of w…

Formulation and Evaluation of Dispersible Tablet of Monteleukast Sodium Open

Aditi Bhatt, Amit Alexander, Akansha Bhandarkar, Pankaj Sahu, Palak Agrawal , et al. · 2018

Monteleukast sodium is most commonly used in treatment of Asthma. It mainly prevents leukotriene mediated effect associated with asthama. Dispersible tablet are film coated or uncoated tablet that can be dispersed in liquid medium before a…

Formulation and Evaluation of directly compressed Floating Tablets of Candesartan Cilexetil for Gastro Retentive Drug Delivery Open

Palak Agrawal, M. Ajazuddin, Tripti Banjare, Swapnil Gupta, Akansha Bhandarkar , et al. · 2018

The candesartan cilexetil floating matrix drug delivery system was design to prolong the gastric residence time and improve its bioavailability. The candesartan cilexetil floating matrix tablet was prepared by using direct compression tech…

Formulation and evaluation of Itraconazole mucoadhesive tablets for sustained release Open

Shradha Devi Diwedi, Amit Alexander, Deepika Choudhary, Palak Agrawal, Tripti Banjare , et al. · 2018

The aim of this research was to prepare and evaluate sustain release mucoadhesive tablet ofitraconazole, in order to overcome its poor biopharmaceutical property and therapeutical efficacy. Itraconazole have low aqueous solubility and high…

A Comprehensive Note on Gastro-Retentive Dosage Forms Open

Priya Patel, Rohini Sahu, Renjil Joshi, Surabhi Armarkar, Tarannum Parveen , et al. · 2018

Controlled release drug delivery system has achieved greater importance in the field of pharmaceutical sciences to provide therapeutic advantages over the conventional drug delivery system. Nowadays, the gastrointestinal controlled drug de…

Formulation and characterization of Virgin Coconut Oil Emulsion (VCOE) for treatment of Alzheimer's disease Open

Shubham Tripathi, Umesh kumar Sahu, Jyotsana Meshram, Ranjeeta Kumari, Dhananjay Tripathi , et al. · 2018

Alzheimer's disease, is a somatic disease that affects the brain. It is a progressive disease that destroys memory and other important mental functions. During this disease, accumulation of cerebral extracellular amyloid, which is mostly c…

Nose-to-brain drug delivery approach: A key to easily accessing the brain for the treatment of Alzheimer's disease Open

Shailendra Saraf, Amit Alexander · 2018

Alzheimer's disease (AD): AD, a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age (early state AD) (Agrawal et al., 2017). As per the Al…

Formulation and evaluation of gastro retentive sustained release tablets of ziprasidone hydrochloride Open

K. C. Sahu, Amit Alexander, Hemlata Thapa, Tripti Banjare, Palak Agrawal , et al. · 2018

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