Amit Ghosh
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View article: Genome‐Scale Community Model‐Guided Development of Bacterial Coculture for Lignocellulose Bioconversion
Genome‐Scale Community Model‐Guided Development of Bacterial Coculture for Lignocellulose Bioconversion Open
Microbial communities have shown promising potential in degrading complex biopolymers, producing value‐added products through collaborative metabolic functionality. Hence, developing synthetic microbial consortia has become a predominant t…
View article: Strategic Conversion of Algal and Lignocellulosic Biomass Wastes as Mixed Feedstock for Enhanced and Environment-Friendly Production Bioethanol
Strategic Conversion of Algal and Lignocellulosic Biomass Wastes as Mixed Feedstock for Enhanced and Environment-Friendly Production Bioethanol Open
View article: Protocol for genome-scale differential flux analysis to interrogate metabolic differences from gene expression data
Protocol for genome-scale differential flux analysis to interrogate metabolic differences from gene expression data Open
View article: Genome-scale community modelling elucidates the metabolic interaction in Indian type-2 diabetic gut microbiota
Genome-scale community modelling elucidates the metabolic interaction in Indian type-2 diabetic gut microbiota Open
View article: IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation
IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation Open
We previously reported that NOD.Scid mice lacking interleukin-15 (IL-15), or IL-15 receptor alpha-chain, develop T-acute lymphoblastic leukemia (T-ALL). To understand the mechanisms by which IL-15 signaling controls T-ALL development, we s…
View article: Deciphering the genetic network and programmed regulation of antimicrobial resistance in bacterial pathogens
Deciphering the genetic network and programmed regulation of antimicrobial resistance in bacterial pathogens Open
Antimicrobial resistance (AMR) in bacteria is an important global health problem affecting humans, animals, and the environment. AMR is considered as one of the major components in the “global one health”. Misuse/overuse of antibiotics in …
View article: Nodulin 16 of <i>Lotus japonicus</i> (Nlj16) regulates the recruitment of Leghemoglobin (LegH) to the infected nodule cell membrane during symbiotic nitrogen fixation
Nodulin 16 of <i>Lotus japonicus</i> (Nlj16) regulates the recruitment of Leghemoglobin (LegH) to the infected nodule cell membrane during symbiotic nitrogen fixation Open
Nitrogenase that catalyses anaerobic symbiotic nitrogen fixation (SNF) in legumes is synthesized by rhizobium. Legume root cells express nodulin proteins after infection with rhizobia. Nodulins have been classified as early and late, refle…
View article: Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic
Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic Open
View article: In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2 Open
View article: Understanding the Mannose Transfer Mechanism of Mycobacterial Phosphatidyl-myo-inositol Mannosyltransferase A from Molecular Dynamics Simulations
Understanding the Mannose Transfer Mechanism of Mycobacterial Phosphatidyl-myo-inositol Mannosyltransferase A from Molecular Dynamics Simulations Open
Glycolipids like phosphatidylinositol hexamannosides (PIM6) and lipoglycans, such as lipomannan (LM) and lipoarabinomannan (LAM), play crucial roles in virulence, survival, and antibiotic resistance of various mycobacterial spec…
View article: Understanding the Biomass Conversion Processes of Bovine Gut Microbiota Through Community-Wide Metabolic Interaction Network
Understanding the Biomass Conversion Processes of Bovine Gut Microbiota Through Community-Wide Metabolic Interaction Network Open
View article: Bacterial Species Metabolic Interaction Network for Deciphering the Lignocellulolytic Systems in Fungal Cultivating Termite Gut Microbiota
Bacterial Species Metabolic Interaction Network for Deciphering the Lignocellulolytic Systems in Fungal Cultivating Termite Gut Microbiota Open
View article: Molecular Insights into Dissolution of Lignin Bunch in Ionic Liquid-Water Mixture for Enhanced Biomass Conversion
Molecular Insights into Dissolution of Lignin Bunch in Ionic Liquid-Water Mixture for Enhanced Biomass Conversion Open
View article: SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma
SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma Open
SOCS1 and SOCS3 genes, frequently repressed in hepatocellular carcinoma (HCC), function as tumor suppressors in hepatocytes. However, TCGA transcriptomic data revealed that SOCS1-low/SOCS3-high specimens displayed more aggressive HCC than …
View article: NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis
NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis Open
The nucleotide-binding leucine-rich repeat-containing receptor (NLR) family protein-5 (NLRC5) controls NF-κB activation and production of inflammatory cytokines in certain cell types. NLRC5 is considered a potential regulator of hepatic fi…
View article: Elucidating the correlation between the number of TTTTGAT heptamer repeats and cholera toxin promoter activity in <i>Vibrio cholerae</i> O1 pandemic strains
Elucidating the correlation between the number of TTTTGAT heptamer repeats and cholera toxin promoter activity in <i>Vibrio cholerae</i> O1 pandemic strains Open
A complex regulatory cascade controls expression of the cholera toxin genes ( ctxAB ) in Vibrio cholerae ; which eventually leads to choleragen (CT) production and secretion, resulting in rice watery diarrhoea. The cholera toxin promoter (…
View article: Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection
Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection Open
The COVID-19 pandemic is posing an unprecedented threat to the whole world. In this regard, it is absolutely imperative to understand the mechanism of metabolic reprogramming of host human cells by SARS-CoV-2. A better understanding of the…
View article: A Re-Look at Cholera Pandemics from Early Times to Now in the Current Era of Epidemiology
A Re-Look at Cholera Pandemics from Early Times to Now in the Current Era of Epidemiology Open
Cholera affects about three million people annually and kills several thousands. Since 1817 seven cholera pandemics have been described. While the nature of the strains responsible for the first four pandemics are not known, the fifth and …
View article: Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS Cov2 infection
Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS Cov2 infection Open
The COVID-19 pandemic is posing an unprecedented threat to the whole world. In this regard, it is absolutely imperative to understand the mechanism of metabolic reprogramming of host human cells by SARS Cov2. A better understanding of the …
View article: Antibacterial action of acriflavine hydrochloride for eradication of the gastric pathogen <i>Helicobacter pylori</i>
Antibacterial action of acriflavine hydrochloride for eradication of the gastric pathogen <i>Helicobacter pylori</i> Open
Helicobacter pylori, a type 1 carcinogen, accounts for numerous gastric cancer-related deaths worldwide. Repurposing existing drugs or developing new ones for a combinatorial approach against increasing antimicrobial resistance is the need…
View article: Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri
Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri Open
View article: Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae
Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae Open
The human pathogen Vibrio cholerae is the causative agent of severe diarrheal disease known as cholera. Of the more than 200 "O" serogroups of this pathogen, O1 and O139 cause cholera outbreaks and epidemics. The rest of the serogroups, co…
View article: Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma
Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma Open
View article: Deciphering the possible role of ctxB7 allele on higher production of cholera toxin by Haitian variant Vibrio cholerae O1
Deciphering the possible role of ctxB7 allele on higher production of cholera toxin by Haitian variant Vibrio cholerae O1 Open
Cholera continues to be an important public health concern in developing countries where proper hygiene and sanitation are compromised. This severe diarrheal disease is caused by the Gram-negative pathogen Vibrio cholerae belonging to sero…
View article: An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling
An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling Open
T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR. ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem SH2 (tSH2) domain connected to the C-terminal kinase domain. The ZA…
View article: Prognostic significance of<i>SOCS1</i>and<i>SOCS3</i>tumor suppressors in hepatocellular carcinoma and its correlation to key oncogenic signaling pathways
Prognostic significance of<i>SOCS1</i>and<i>SOCS3</i>tumor suppressors in hepatocellular carcinoma and its correlation to key oncogenic signaling pathways Open
Suppressor of cytokine signaling (SOCS) proteins SOCS1 and SOCS3 are considered tumor suppressors in liver hepatocellular carcinoma (LIHC). To gain insight into the underlying molecular mechanisms, the expression of SOCS1/ SOCS3 was evalua…
View article: A Point Mutation in <i>carR</i> Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription
A Point Mutation in <i>carR</i> Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription Open
Antimicrobial peptides play an important role in host defense against Vibrio cholerae . Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits…
View article: Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri
Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri Open
Background Lachancea kluyveri , a weak Crabtree positive yeast, has been extensively studied for its unique URC pyrimidine catabolism pathway. It produces more biomass than Saccharomyces cerevisiae due to the underlying weak Crabtree effec…
View article: Structure and dynamics of ionic liquid tolerant hyperthermophilic endoglucanase Cel12A from <i>Rhodothermus marinus</i>
Structure and dynamics of ionic liquid tolerant hyperthermophilic endoglucanase Cel12A from <i>Rhodothermus marinus</i> Open
Understanding the behavior of ionic liquid tolerant hyperthermophilic endoglucanase Cel12A from Rhodothermus marinus in different concentrations of EmimAc.
View article: An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling
An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling Open
T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR. ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem SH2 (tSH2) domain connected to the C-terminal kinase domain. The ZA…