Amit Verma
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View article: Exposure to Household Air Pollution From Biomass Cooking and Severe Pneumonia in Infants
Exposure to Household Air Pollution From Biomass Cooking and Severe Pneumonia in Infants Open
Importance Household air pollution from biomass cooking is considered an important risk factor for child pneumonia. Objective To evaluate the longitudinal association between exposure to particulate matter with a diameter of less than or e…
View article: Isolating subsurface fluorescence in macroscopic lifetime imaging via high-spatial-frequency structured illumination
Isolating subsurface fluorescence in macroscopic lifetime imaging via high-spatial-frequency structured illumination Open
Macroscopic fluorescence lifetime imaging (MFLI) has emerged as a robust, non-invasive imaging technique offering quantitative insights into physiological and molecular processes within live tissues, independent of fluorophore concentratio…
View article: Assessing the performance of the Iceland screens, treats, or prevents multiple myeloma (iStopMM) model in a multicultural Bronx cohort: implications for monoclonal gammopathy of undetermined significance risk stratification
Assessing the performance of the Iceland screens, treats, or prevents multiple myeloma (iStopMM) model in a multicultural Bronx cohort: implications for monoclonal gammopathy of undetermined significance risk stratification Open
View article: Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells
Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells Open
Acquired non-genetic resistance mechanisms to existing therapies contribute to poor outcomes for acute myeloid leukemia (AML) patients, and inability to target leukemic stem cells (LSCs) can lead to relapse. To overcome these challenges, w…
View article: CNS Involvement by North American-Adult T-cell Leukemia/Lymphoma Is Associated With Discrete Dissemination Patterns and Molecular Profiles, Involving XPO1 E571 and KLF2/PI3KCD in Selected Cases
CNS Involvement by North American-Adult T-cell Leukemia/Lymphoma Is Associated With Discrete Dissemination Patterns and Molecular Profiles, Involving XPO1 E571 and KLF2/PI3KCD in Selected Cases Open
PURPOSE CNS involvement in North American adult T-cell leukemia/lymphoma (NA-ATLL) remains poorly understood. This study examined the CNS involvement in patients with ATLL treated at a tertiary hospital in New York City. METHODS CNS involv…
View article: Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts
Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts Open
View article: Depth-Resolved Macroscopic Fluorescence Lifetime Imaging via High-Spatial-Frequency Structured Illumination
Depth-Resolved Macroscopic Fluorescence Lifetime Imaging via High-Spatial-Frequency Structured Illumination Open
Significance Macroscopic Fluorescence Lifetime Imaging (MFLI) is a powerful, non-invasive imaging modality that offers robust, physiologically relevant contrast largely independent of fluorophore concentration, excitation intensity, and ti…
View article: 468 | FIRST‐IN‐HUMAN CART CELLS FOR ADULT T‐CELL LEUKEMIA/LYMPHOMA USING CTX130, A CD70‐TARGETED ALLOGENEIC CRISPR‐Cas9‐ENGINEERED CART‐CELLS. COBALT‐LYM STUDY COHORT
468 | FIRST‐IN‐HUMAN CART CELLS FOR ADULT T‐CELL LEUKEMIA/LYMPHOMA USING CTX130, A CD70‐TARGETED ALLOGENEIC CRISPR‐Cas9‐ENGINEERED CART‐CELLS. COBALT‐LYM STUDY COHORT Open
View article: Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromes
Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromes Open
Anemia is the primary clinical manifestation of myelodysplastic syndromes (MDSs), but the molecular pathogenesis of ineffective erythropoiesis remains incompletely understood. Luspatercept, an activin receptor 2B (ACVRIIB-Fc) ligand trap, …
View article: Affinity-matured CD72-targeting Nanobody CAR T-cells Enhance Elimination of Antigen-Low B-cell Malignancies
Affinity-matured CD72-targeting Nanobody CAR T-cells Enhance Elimination of Antigen-Low B-cell Malignancies Open
Background Chimeric antigen receptor (CAR) T-cell therapies are highly efficacious for several different hematologic cancers. However, for most CAR T targets it is observed that low surface antigen density on tumors can significantly reduc…
View article: Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium
Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium Open
View article: Complexities of Barakat syndrome: Insights from two challenging cases
Complexities of Barakat syndrome: Insights from two challenging cases Open
Barakat syndrome, characterized by the triad of hypoparathyroidism, deafness, and renal disease, also known as hypoparathyroidism, sensorineural deafness, and renal disease (HDR) syndrome, is an autosomal dominant, rare genetic disease cau…
View article: Single-cell analysis of oncolytic virotherapy in adult T-cell leukemia/lymphoma
Single-cell analysis of oncolytic virotherapy in adult T-cell leukemia/lymphoma Open
Adult T-cell leukemia/lymphoma (ATLL), an aggressive T-cell malignancy associated with human T-cell leukemia virus type 1, presents significant therapeutic challenges due to high relapse rates and resistance to therapy. Here, we present th…
View article: Venetoclax plus daunorubicin and cytarabine for newly diagnosed acute myeloid leukemia: results of a phase 1b study
Venetoclax plus daunorubicin and cytarabine for newly diagnosed acute myeloid leukemia: results of a phase 1b study Open
Venetoclax (Ven), when combined with intensive chemotherapy, shows promise for untreated acute myeloid leukemia (AML), but its integration with the 7+3 regimen remains underexplored. In a phase 1b study, we assessed the safety and efficacy…
View article: Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies
Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies Open
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View article: A germline FLT3 variant in aplastic anemia
A germline FLT3 variant in aplastic anemia Open
FMS-like tyrosine kinase 3 ( FLT3 ) genetic variants are commonly seen in high-grade myeloid neoplasms and are typically gain-of-function mutations associated with a proliferative disease phenotype. Inactivating FLT3 variants have been les…
View article: Advancing drug development in myelodysplastic syndromes
Advancing drug development in myelodysplastic syndromes Open
Myelodysplastic syndromes/neoplasms (MDSs) are heterogeneous stem cell malignancies characterized by poor prognosis and no curative therapies outside of allogeneic hematopoietic stem cell transplantation. Despite some recent approvals by t…
View article: Quantifying Lifetime Uncertainty in Gated-ICCD Fluorescence Lifetime Imaging
Quantifying Lifetime Uncertainty in Gated-ICCD Fluorescence Lifetime Imaging Open
Fluorescence lifetime imaging (FLI) is a versatile technique for quantifying molecular processes in biomedical applications. Wide-field FLI analyzes fluorescence temporal decays computationally, often using intensified charge-coupled devic…
View article: Parallel Online Directed Acyclic Graph Exploration for Atlasing Soft-Matter Assembly Configuration Spaces
Parallel Online Directed Acyclic Graph Exploration for Atlasing Soft-Matter Assembly Configuration Spaces Open
The paper formalizes a version of parallel online directed acyclic graph (DAG) exploration, general enough to be readily mapped to many computational scenarios. In both the offline and online versions, vertices are weighted with the work u…
View article: A weekly low-dose regimen of decitabine and venetoclax is efficacious and less myelotoxic in a racially diverse cohort
A weekly low-dose regimen of decitabine and venetoclax is efficacious and less myelotoxic in a racially diverse cohort Open
A metronomic, low-dose schedule of decitabine and venetoclax was safe and effective in myeloid malignancies with few dose reductions or interruptions in an older diverse population. Median overall survival for patients with acute myeloid l…
View article: Testosterone therapy as a novel approach to the management of cytopenias in myelodysplastic neoplasms: a review of literature and case report
Testosterone therapy as a novel approach to the management of cytopenias in myelodysplastic neoplasms: a review of literature and case report Open
Purpose To explore the potential of testosterone therapy in managing cytopenias in myelodysplastic neoplasm and investigate the link between hypogonadism and hematologic malignancies. Methods A case of a patient with intermediate-risk myel…
View article: Dynamic Beam-Stabilized, Additive-Printed Flexible Antenna Arrays with On-Chip Rapid Insight Generation
Dynamic Beam-Stabilized, Additive-Printed Flexible Antenna Arrays with On-Chip Rapid Insight Generation Open
Conformal phased arrays promise shape-changing properties, multiple degrees of freedom to the scan angle, and novel applications in wearables, aerospace, defense, vehicles, and ships. However, they have suffered from two critical limitatio…
View article: eLife Assessment: Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia
eLife Assessment: Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia Open
Myeloid leukemias, diseases marked by aggressiveness and poor outcomes, are frequently triggered by oncogenic translocations. In the case of chronic myelogenous leukemia (CML) the BCR-ABL fusion initiates chronic phase disease with second …
View article: Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome Open
View article: Machinability investigation of natural fibers reinforced polymer matrix composite under drilling: Leveraging machine learning in bioengineering applications
Machinability investigation of natural fibers reinforced polymer matrix composite under drilling: Leveraging machine learning in bioengineering applications Open
The growing demand for fiber-reinforced polymer (FRP) in industrial applications has prompted the exploration of natural fiber-based composites as a viable alternative to synthetic fibers. Using jute–rattan fiber-reinforced composite offer…
View article: Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape Open
View article: Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency
Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency Open
While therapies targeting CD19 by antibodies, chimeric antigen receptor T cells (CAR-T), and T cell engagers have improved the response rates in B cell malignancies, the emergence of resistant cell populations with low CD19 expression can …
View article: Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome Open
Background Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating the regeneration of the bone marrow (BM), namely the hematopoietic stem and p…
View article: Research and clinical updates on IRAK4 and its roles in inflammation and malignancy: themes and highlights from the 1st symposium on IRAK4 in cancer
Research and clinical updates on IRAK4 and its roles in inflammation and malignancy: themes and highlights from the 1st symposium on IRAK4 in cancer Open
The intracellular serine/threonine interleukin 1 receptor-associated kinase 4 (IRAK4) is necessary for most signaling by activated Toll-like receptors (TLRs). Activation of IRAK4 drives activation of nuclear factor kappa B (NF-κB) and so p…
View article: Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation
Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation Open
The role of splicing dysregulation in cancer is underscored by splicing factor mutations; however, its impact in the absence of such rare mutations is poorly understood. To reveal complex patient subtypes and putative regulators of pathoge…