Amit Kapoor
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View article: iHALT unlocks liver functionality as a surrogate secondary lymphoid organ
iHALT unlocks liver functionality as a surrogate secondary lymphoid organ Open
Upon viral infection, the current paradigm of humoral immunity posits that germinal centre reactions occurring within secondary lymphoid organs (SLOs) yield effector plasma cells that subsequently traffic to infected organs or the bone mar…
View article: In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus
In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus Open
The lack of immunocompetent animal models severely impedes the development of vaccines against hepatitis C virus (HCV) and researchers have therefore explored the application of surrogate virus models. Norway rat hepacivirus 1 (NrHV) is a …
View article: Design and nonviral delivery of live attenuated vaccine to prevent chronic hepatitis C virus-like infection
Design and nonviral delivery of live attenuated vaccine to prevent chronic hepatitis C virus-like infection Open
View article: Integrated analysis of protein sequence and structure redefines viral diversity and the taxonomy of the <i>Flaviviridae</i>
Integrated analysis of protein sequence and structure redefines viral diversity and the taxonomy of the <i>Flaviviridae</i> Open
The Flaviviridae are a family of non-segmented positive-sense enveloped RNA viruses containing significant pathogens including hepatitis C virus and yellow fever virus. Recent large-scale metagenomic surveys have identified many diverse RN…
View article: Unlocking the Power of Blockchain to Overcome Business Challenges and Enhance Efficiency: A Systematic Review & Bibliometric Analysis
Unlocking the Power of Blockchain to Overcome Business Challenges and Enhance Efficiency: A Systematic Review & Bibliometric Analysis Open
Blockchain technology is a versatile technology developed using various techniques in the 21st-century digital era and extensively used across industries. This paper emphasizes the benefits of blockchain technology in enhancing business ef…
View article: Determinants of pegivirus persistence, cross-species infection, and adaptation in the laboratory mouse
Determinants of pegivirus persistence, cross-species infection, and adaptation in the laboratory mouse Open
Viruses capable of causing persistent infection have developed sophisticated mechanisms for evading host immunity, and understanding these processes can reveal novel features of the host immune system. One such virus, human pegivirus (HPgV…
View article: Enhancing Esg Data Integrity Through Blockchain: A Comparative Analysis Across Emerging Markets
Enhancing Esg Data Integrity Through Blockchain: A Comparative Analysis Across Emerging Markets Open
The Environmental, Social and Governance (ESG) system of practices are increasingly part of investment and corporate responsibility. Nonetheless, ESG reporting in such emerging markets is usually marred with the issue of data opacity, disp…
View article: Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection
Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection Open
Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined due to the lack of an informative animal model. We recently described acute and chronic rodent HCV-like virus (RHV) infections in lab mice. Here, we d…
View article: Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae
Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae Open
View article: Broadcasting Forensics Using Machine Learning Approaches
Broadcasting Forensics Using Machine Learning Approaches Open
Broadcasting forensic is the practice of using scientific methods and techniques to analyse and authenticate Multimedia content. Over the past decade, consumer-grade imaging sensors have become increasingly prevalent, generating vast quant…
View article: Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission
Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission Open
Live-attenuated vaccines (LAVs) are able to induce robust immune responses, including both humoral and cellular immunity, representing a very promising option to provide broad and long-term immunity. To develop LAVs for SARS-CoV-2, we engi…
View article: Recombinant measles virus expressing prefusion spike protein stabilized by six rather than two prolines is more efficacious against SARS‐CoV‐2 infection
Recombinant measles virus expressing prefusion spike protein stabilized by six rather than two prolines is more efficacious against SARS‐CoV‐2 infection Open
Measles virus (MeV) has been an excellent vector platform for delivering vaccines against many pathogens because of its high safety and efficacy, and induction of long‐lived immunity. Early in the COVID‐19 pandemic, a recombinant MeV (rMeV…
View article: CD8+ T cells contribute to diet-induced memory deficits in aged male rats
CD8+ T cells contribute to diet-induced memory deficits in aged male rats Open
View article: SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern Open
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for neutralizing antibodies (NAbs). The S protein trimer is anchored in the virion membrane in its prefusion (preS) but metastable for…
View article: A highly efficacious live attenuated mumps virus–based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike
A highly efficacious live attenuated mumps virus–based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike Open
With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for this population is urgently needed. The MMR (measles/mumps/rubella) vaccine has been one of the safest and most effective human vaccines used in infa…
View article: Sudden deaths due to accidental leakage of Lindane from a storage tank in a village, Sitapur, Uttar Pradesh, India, 2020
Sudden deaths due to accidental leakage of Lindane from a storage tank in a village, Sitapur, Uttar Pradesh, India, 2020 Open
Background: Chemical leakages cause devastating health effects on humans. On 6 February 2020, seven deaths were reported following a hazardous chemical leakage in a village in Uttar Pradesh, India. We investigated the event to identify the…
View article: Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV
Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV Open
Background and Aims Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining c…
View article: Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission
Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission Open
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to a worldwide Coronavirus Disease 2019 (COVID-19) pandemic. Despite high efficacy of the authorized vaccines, protection against the surging variants of concern (VoC) wa…
View article: Table of contents
Table of contents Open
Cover Figure:Rosenblatt et al investigated the role of racial disparities in access to liver transplantation in the United States.The above figure depicts the listing to death ratios (LDR) by state.The higher the LDR, the more likely patie…
View article: Hepatitis C Virus Vaccine Research: Time to Put Up or Shut Up
Hepatitis C Virus Vaccine Research: Time to Put Up or Shut Up Open
Unless urgently needed to prevent a pandemic, the development of a viral vaccine should follow a rigorous scientific approach. Each vaccine candidate should be designed considering the in-depth knowledge of protective immunity, followed by…
View article: A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters Open
Viral mRNA cap methyltransferase (MTase) is essential for mRNA stability, protein translation, and innate immune evasion. Thus, viral mRNA cap MTase activity is a novel target for development of live attenuated or live vectored vaccine can…
View article: Rodent Virus Diversity and Differentiation across Post-Katrina New Orleans
Rodent Virus Diversity and Differentiation across Post-Katrina New Orleans Open
Concern about elevated disease risk following disasters has been growing with the progression of global trends in urbanization and climate, in part because shifts in socioecological conditions can promote greater human contact with pathoge…
View article: Adenovirus-vectored T cell vaccine for hepacivirus shows reduced effectiveness against a CD8 T cell escape variant in rats
Adenovirus-vectored T cell vaccine for hepacivirus shows reduced effectiveness against a CD8 T cell escape variant in rats Open
There is an urgent need for a vaccine to prevent chronic infection by hepatitis C virus (HCV) and its many genetic variants. The first human vaccine trial, using recombinant viral vectors that stimulate pan-genotypic T cell responses again…
View article: Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection
Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection Open
Background and Aims Equine hepacivirus (EqHV) is phylogenetically the closest relative of HCV and shares genome organization, hepatotropism, transient or persistent infection outcome, and the ability to cause hepatitis. Thus, EqHV studies …
View article: A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike
A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike Open
Significance Measles virus (MeV) vaccine is one of the safest and most efficient vaccines with a track record in children. Here, we generated a panel of rMeV-based vaccines with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
View article: Characterization of the GBoV1 Capsid and Its Antibody Interactions
Characterization of the GBoV1 Capsid and Its Antibody Interactions Open
Human bocavirus 1 (HBoV1) has gained attention as a gene delivery vector with its ability to infect polarized human airway epithelia and 5.5 kb genome packaging capacity. Gorilla bocavirus 1 (GBoV1) VP3 shares 86% amino acid sequence ident…
View article: Bocavirus Episome in Infected Human Tissue Contains Non-Identical Termini
Bocavirus Episome in Infected Human Tissue Contains Non-Identical Termini Open
Human bocaviruses (HBoV) are highly prevalent human infections whose pathogenic potential remains unknown. Recent identification of the first non-human primate bocavirus [1] in captive gorillas raised the possibility of the persistent natu…
View article: Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis
Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis Open
Pegiviruses frequently cause persistent infection (as defined by >6 months), but unlike most other Flaviviridae members, no apparent clinical disease. Human pegivirus (HPgV, previously GBV-C) is detectable in 1-4% of healthy individuals an…
View article: Presence of Segmented Flavivirus Infections in North America
Presence of Segmented Flavivirus Infections in North America Open
Identifying viruses in synanthropic animals is necessary for understanding the origin of many viruses that can infect humans and developing strategies to prevent new zoonotic infections. The white-footed mouse, Peromyscus leucopus, is one …
View article: Priming of Antiviral CD8 T Cells without Effector Function by a Persistently Replicating Hepatitis C-Like Virus
Priming of Antiviral CD8 T Cells without Effector Function by a Persistently Replicating Hepatitis C-Like Virus Open
Development of vaccines against hepatitis C virus (HCV), a major cause of cirrhosis and cancer, has been stymied by a lack of animal models. The recent discovery of an HCV-like rodent hepacivirus (RHV) enabled the development of such a mod…