Amit Kaura
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View article: Anti‐Malondialdehyde Low‐Density Lipoprotein Antibodies and Valvular Calcification: A Substudy of the SCOT‐HEART Trial
Anti‐Malondialdehyde Low‐Density Lipoprotein Antibodies and Valvular Calcification: A Substudy of the SCOT‐HEART Trial Open
Background Coronary computed tomography–derived valve calcification is becoming increasingly important in the multi‐modality assessment of valvular disease, especially in aortic and mitral valve disease. Separately, natural antibodies targ…
View article: 2-042 Ethnic disparities in mortality from acute coronary syndrome: a multicentre cohort study
2-042 Ethnic disparities in mortality from acute coronary syndrome: a multicentre cohort study Open
View article: The relationship of baseline high-sensitivity C-reactive protein with incident cardiovascular events and all-cause mortality over 20 years
The relationship of baseline high-sensitivity C-reactive protein with incident cardiovascular events and all-cause mortality over 20 years Open
View article: Evaluation of the Digital Support Tool Gro Health W8Buddy as Part of Tier 3 Weight Management Service: Observational Study
Evaluation of the Digital Support Tool Gro Health W8Buddy as Part of Tier 3 Weight Management Service: Observational Study Open
Background The escalating prevalence of obesity worldwide increases the risk of chronic diseases and diminishes life expectancy, with a growing economic burden necessitating urgent intervention. The existing tiered approach to weight manag…
View article: Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study
Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study Open
Background Left ventricular diastolic function as assessed by tissue Doppler echocardiography predicts cardiovascular event rates at 4 years of follow-up in patients with hypertension. Our aim was to evaluate whether this extends to predic…
View article: Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome
Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome Open
Background Reduced estimated glomerular filtration rate (eGFR) is associated with lower use of invasive management and increased mortality after acute coronary syndrome (ACS). The reasons for this are unclear. Methods A retrospective clini…
View article: Evaluating the Effectiveness of a Face-to-Face Weight Management Intervention in Maidstone, United Kingdom: A Real-World Evaluation (Preprint)
Evaluating the Effectiveness of a Face-to-Face Weight Management Intervention in Maidstone, United Kingdom: A Real-World Evaluation (Preprint) Open
BACKGROUND Obesity remains a critical global public health issue, contributing to severe health conditions such as type 2 diabetes and cardiovascular diseases. In Maidstone, United Kingdom the obesity rate stands at 16.3% higher than the …
View article: Phenogrouping heart failure with preserved or mildly reduced ejection fraction using electronic health record data
Phenogrouping heart failure with preserved or mildly reduced ejection fraction using electronic health record data Open
Background Heart failure (HF) with preserved or mildly reduced ejection fraction includes a heterogenous group of patients. Reclassification into distinct phenogroups to enable targeted interventions is a priority. This study aimed to iden…
View article: Prognostic significance of troponin in patients with malignancy (NIHR Health Informatics Collaborative TROP-MALIGNANCY study)
Prognostic significance of troponin in patients with malignancy (NIHR Health Informatics Collaborative TROP-MALIGNANCY study) Open
Background Cardiac troponin is commonly raised in patients presenting with malignancy. The prognostic significance of raised troponin in these patients is unclear. Objectives We sought to investigate the relation between troponin and morta…
View article: A Remote acute assessment of patients with high cardiovascular risk post-acute coronary syndrome (TELE-ACS): a randomized controlled trial
A Remote acute assessment of patients with high cardiovascular risk post-acute coronary syndrome (TELE-ACS): a randomized controlled trial Open
Background Unplanned re-admissions after acute coronary syndrome (ACS) remain high. Telemedicine programmes can provide remote diagnostic information to aid clinical decision that could optimize and reduce the need to access hospital care.…
View article: D Leveraging machine learning for rapid rule-out of acute coronary syndromes
D Leveraging machine learning for rapid rule-out of acute coronary syndromes Open
Background Current Acute Coronary Syndromes (ACS) rule-out algorithms rely on a combination of clinical assessment and measuring troponin levels. It can take several hours for troponin levels to rise after a myocardial infarction, so initi…
View article: Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data
Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data Open
Objective The COVID-19 pandemic was associated with a reduction in the incidence of myocardial infarction (MI) diagnosis, in part because patients were less likely to present to hospital. Whether changes in clinical decision making with re…
View article: Diagnostic and prognostic value of an ejection fraction adjusted for myocardial remodeling
Diagnostic and prognostic value of an ejection fraction adjusted for myocardial remodeling Open
Introduction Ejection fraction (EF) is widely used to evaluate heart function during heart failure (HF) due to its simplicity compared but it may misrepresent cardiac function during ventricular hypertrophy, especially in heart failure wit…
View article: AI Hesitancy and Acceptability—Perceptions of AI Chatbots for Chronic Health Management and Long COVID Support: Survey Study
AI Hesitancy and Acceptability—Perceptions of AI Chatbots for Chronic Health Management and Long COVID Support: Survey Study Open
Background Artificial intelligence (AI) chatbots have the potential to assist individuals with chronic health conditions by providing tailored information, monitoring symptoms, and offering mental health support. Despite their potential be…
View article: Evaluation of the digital support tool Gro Health W8Buddy as part of Tier 3 Weight Management Service
Evaluation of the digital support tool Gro Health W8Buddy as part of Tier 3 Weight Management Service Open
Introduction: The escalating prevalence of obesity worldwide increases the risk of chronic diseases and diminishes life expectancy with growing economic burden necessitating intervention.1 The existing tiered approach to weight management,…
View article: Mortality prediction using high-sensitivity troponin after coronary artery bypass surgery
Mortality prediction using high-sensitivity troponin after coronary artery bypass surgery Open
Introduction Recommendations regarding the threshold levels of cardiac troponin elevations for the definition of peri-operative myocardial infarction and clinically important peri-procedural myocardial injury in patients undergoing cardiac…
View article: Diagnostic and prognostic value of an ejection fraction corrected for myocardial remodelling
Diagnostic and prognostic value of an ejection fraction corrected for myocardial remodelling Open
Introduction Despite clinical guideline recommendations to use left ventricular ejection fraction (EF) as a marker of left ventricular function in heart failure (HF), it is prone to measurement error, is load dependent and is skewed during…
View article: The Relationship Between Cardiac Troponin in People Hospitalised for Exacerbation of COPD and Major Adverse Cardiac Events (MACE) and COPD Readmissions
The Relationship Between Cardiac Troponin in People Hospitalised for Exacerbation of COPD and Major Adverse Cardiac Events (MACE) and COPD Readmissions Open
An elevated troponin level at the time of COPD exacerbation may be a useful tool for predicting MACE in COPD patients. The relationship between degree of troponin elevation and risk of future events is complex and requires further investig…
View article: Baseline high sensitivity C-Reactive Protein predicts incident cardiovascular events and all-cause mortality in the ASCOT Study at 20-years
Baseline high sensitivity C-Reactive Protein predicts incident cardiovascular events and all-cause mortality in the ASCOT Study at 20-years Open
Introduction The prediction of future cardiovascular events in those at greatest risk is essential to optimise preventative therapies appropriately and effectively. The value of high sensitivity C-reactive Protein (hsCRP) has been question…
View article: Anti-MDA-LDL antibody levels indicate protection from coronary CT-derived valve calcification in the SCOT-HEART Trial
Anti-MDA-LDL antibody levels indicate protection from coronary CT-derived valve calcification in the SCOT-HEART Trial Open
Introduction Coronary CT-derived valve calcification is becoming increasingly important in the multi-modality assessment of valvular disease, especially in aortic and mitral stenosis, where trans-catheter structural heart interventions may…
View article: Real-world evaluation of a Hybrid Children’s and Young Person’s Weight Management Service to families in Slough (Preprint)
Real-world evaluation of a Hybrid Children’s and Young Person’s Weight Management Service to families in Slough (Preprint) Open
BACKGROUND Childhood obesity constitutes a significant public health issue worldwide. Slough, a region in the United Kingdom, harbours some of the most socioeconomically deprived areas, resulting in a disproportionately higher prevalence …
View article: Antimalondialdehyde Low-Density Lipoprotein Antibody Levels Predict Low-Attenuation Plaque in the SCOT-HEART Trial
Antimalondialdehyde Low-Density Lipoprotein Antibody Levels Predict Low-Attenuation Plaque in the SCOT-HEART Trial Open
View article: AI Hesitancy and Acceptability: Perceptions of AI Chatbots for Chronic Health Management and Long-COVID Support (Preprint)
AI Hesitancy and Acceptability: Perceptions of AI Chatbots for Chronic Health Management and Long-COVID Support (Preprint) Open
BACKGROUND AI chatbots have the potential to assist individuals with long-term health conditions by providing tailored information, monitoring symptoms, and offering emotional support. Despite their potential benefits, research on public …
View article: 209 A trial emulation comparing thromboprophylaxis versus no thromboprophylaxis among ward-based patients with covid-19
209 A trial emulation comparing thromboprophylaxis versus no thromboprophylaxis among ward-based patients with covid-19 Open
Introduction Current guidance recommends thromboprophylaxis in COVID-19 patients during hospitalization for the prevention of venous thromboembolism and reduction in mortality risk. These recommendations are derived from small observationa…
View article: BS8 High sensitivity C-reactive protein at baseline predicts cardiovascular outcomes at 20-year follow-up in the ascot legacy study
BS8 High sensitivity C-reactive protein at baseline predicts cardiovascular outcomes at 20-year follow-up in the ascot legacy study Open
Rationale for the Study The prediction of future cardiovascular events in those with vascular risk factors is important to appropriately optimise preventative therapies in those at greatest risk. The value of high sensitivity C-reactive Pr…
View article: 43 Elevated troponin during hospital admission with infection associated with increased short and long-term mortality
43 Elevated troponin during hospital admission with infection associated with increased short and long-term mortality Open
Introduction Troponin elevation in patients with sepsis is associated with increased in-hospital mortality in small studies of patients requiring intensive care, and more recently in patients suffering COVID-19. Previous meta-analyses have…
View article: 174 The diagnostic and prognostic value of left ventricular ejection fraction corrected for myocardial remodelling
174 The diagnostic and prognostic value of left ventricular ejection fraction corrected for myocardial remodelling Open
Introduction Despite clinical guideline recommendations to use left ventricular ejection fraction (EF) as a marker of left ventricular function in heart failure (HF), it is prone to measurement error, is load dependent and is skewed during…
View article: BS9 Antibodies against oxidised low-density lipoprotein and valve calcification in the scot-heart trial
BS9 Antibodies against oxidised low-density lipoprotein and valve calcification in the scot-heart trial Open
Background Coronary CT-derived valve calcification is becoming increasingly important in the multi-modality assessment of valvular disease, especially in aortic and mitral stenosis, where trans-catheter structural heart interventions may b…
View article: 193 Using high-sensitivity troponin for mortality prediction after coronary artery bypass graft surgery
193 Using high-sensitivity troponin for mortality prediction after coronary artery bypass graft surgery Open
Introduction Recommendations regarding the threshold levels of cardiac troponin elevations for the definition of peri-operative myocardial infarction and clinically important peri-procedural myocardial injury in patients undergoing cardiac…
View article: Real-world evaluation of a digital Tier 2 Weight Management Service to residents of Cornwall living with obesity (Preprint)
Real-world evaluation of a digital Tier 2 Weight Management Service to residents of Cornwall living with obesity (Preprint) Open
BACKGROUND Obesity is a major global public health issue. In the United Kingdom, Cornwall is considered one of the most deprived areas with disproportionately higher rates of overweight and obesity. This study examined the demographics an…