Amit Kaushik
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View article: In-vivo effects of IVT-15 - A traditional knowledge-inspired formulation for the management of rheumatoid arthritis
In-vivo effects of IVT-15 - A traditional knowledge-inspired formulation for the management of rheumatoid arthritis Open
View article: Ayurvedic Approach in the Successful Management of Psoriasis
Ayurvedic Approach in the Successful Management of Psoriasis Open
Psoriasis is an autoimmune skin disorder characterized by dry, scaly patches and inflammation, often exacerbated by environmental factors, stress, and local injuries. Ayurveda, addresses psoriasis as a result of Tridosha imbalance, particu…
View article: An explainable AI-based framework for predicting and optimizing blast-induced ground vibrations in surface mining
An explainable AI-based framework for predicting and optimizing blast-induced ground vibrations in surface mining Open
Blast induced ground vibrations (BIGV) pose critical challenges in surface mining, threatening structural integrity, worker safety, and environmental compliance. This study proposes a novel hybrid artificial intelligence (AI) framework tha…
View article: Synthesis and Evaluation of Novel Oxanthrene Scaffold-derived Oxazolidinone Antibiotics with Potent Antitubercular Activity and Low Cellular Toxicity
Synthesis and Evaluation of Novel Oxanthrene Scaffold-derived Oxazolidinone Antibiotics with Potent Antitubercular Activity and Low Cellular Toxicity Open
Oxazolidinones are a class of antibiotics used to treat bacterial infections in humans and are a component of the standard-of-care regimen for multidrug-resistant tuberculosis. However, current clinically used examples of the class display…
View article: Antiprotozoal agents – Integration of drug discovery, medicinal chemistry, and advanced computational approaches: An in-depth review
Antiprotozoal agents – Integration of drug discovery, medicinal chemistry, and advanced computational approaches: An in-depth review Open
Protozoal diseases have been a global burden for decades, including fatal diseases that can lead to death, particularly in low- and middle-income countries. Many of these diseases are classified under Neglected Tropical Diseases (NTDs). Di…
View article: Agreement and correlation between WHO-UMC Causality scale and the Naranjo algorithm for causality assessment of adverse drug reactions at tertiary care center in Northern India
Agreement and correlation between WHO-UMC Causality scale and the Naranjo algorithm for causality assessment of adverse drug reactions at tertiary care center in Northern India Open
Background: To develop a structured and harmonized causality assessment method has been a holy grail in pharmacovigilance. The Pharmacovigilance Programme of India (PvPI) recommends the use of the World Health Organization-Uppsala Monitori…
View article: Leishmaniasis: A multifaceted approach to diagnosis, maladies, drug repurposing and way forward
Leishmaniasis: A multifaceted approach to diagnosis, maladies, drug repurposing and way forward Open
More than 20 species of the protozoan parasite Leishmania cause leishmaniasis, a disease spread by sand flies. The WHO lists leishmaniasis as one of the most ubiquitous neglected tropical illnesses. As per the reports, more than 1.3 millio…
View article: A comprehensive computational study of non-synonymous SNPs (nsSNPs) of NTRK1 Gene using conservation, stability, docking, and simulation approaches
A comprehensive computational study of non-synonymous SNPs (nsSNPs) of NTRK1 Gene using conservation, stability, docking, and simulation approaches Open
View article: Josephson voltage standards as ultra-stable low-noise voltage sources for precision Penning-trap experiments
Josephson voltage standards as ultra-stable low-noise voltage sources for precision Penning-trap experiments Open
A high-precision Penning-trap experiment was operated with a programmable 20 V Josephson voltage source, providing a significantly higher stability of the electrostatic trapping potential. This increased the motional frequency stability of…
View article: Hyaluronidase impacts exposures of long-acting injectable paliperidone palmitate in rodent models
Hyaluronidase impacts exposures of long-acting injectable paliperidone palmitate in rodent models Open
A significant challenge in the development of long-acting injectable drug formulations, especially for anti-infective agents, is delivering an efficacious dose within a tolerable injection volume. Co-administration of the extracellular mat…
View article: Mounting Frame Design - an Integrated Approach Through Analysis and Testing
Mounting Frame Design - an Integrated Approach Through Analysis and Testing Open
The Mounting frame, a structural unit to house the on-board electronic equipments, has been designed and analyzed. Due to the imposed vibration environment, it is essential to impose constraints of not having any resonance of equipped moun…
View article: Relation Between HbA1c and Lipid Profile Among Prediabetics, Diabetics, and Non-diabetics: A Hospital-Based Cross-Sectional Analysis
Relation Between HbA1c and Lipid Profile Among Prediabetics, Diabetics, and Non-diabetics: A Hospital-Based Cross-Sectional Analysis Open
In hyperglycemia-induced dyslipidemia, raised triglyceride and VLDL were the most common findings, and combined lipid abnormalities were more commonly seen as compared to a single abnormality in the lipid profile. Patients with poor glycem…
View article: Disparity in Relation to Covid-19 Preventive Behaviour and Associated Myths among Rural and Urban Residents of Lucknow: A Community Based Study
Disparity in Relation to Covid-19 Preventive Behaviour and Associated Myths among Rural and Urban Residents of Lucknow: A Community Based Study Open
Introduction: For curbing Covid-19 disease, adequate knowledge, attitude, and practices of both rural and urban population for Covid-19 disease prevention is required along with busting of the associated myths. Objectives: To assess the Kn…
View article: The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection Open
Staphylococcus aureus is the predominant cause of bloodstream, skin, and bone infections in humans. Resistance to commonly used antibiotics is a growing concern, making it more difficult to treat staphylococcal infections.
View article: Structure–Activity Relationship of Penem Antibiotic Side Chains Used against Mycobacteria Reveals Highly Active Compounds
Structure–Activity Relationship of Penem Antibiotic Side Chains Used against Mycobacteria Reveals Highly Active Compounds Open
The rise of antibiotic-resistant Mycobacterium tuberculosis and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat these diseases. Recently, a new penem, T405
View article: Assessment of knowledge and their practices regarding malaria among members of Village Health Sanitation Committee in rural Uttar Pradesh: A cross-sectional study
Assessment of knowledge and their practices regarding malaria among members of Village Health Sanitation Committee in rural Uttar Pradesh: A cross-sectional study Open
Background: In 2019, the global number of malaria cases was estimated at 229 million. An estimated 409,000 deaths were attributed to malaria in 2019. Under-five children are the most susceptible to malaria, accounting for 67% (274,000) of …
View article: Cutaneous metastasis of invasive ductal carcinoma on FNAC: A case report
Cutaneous metastasis of invasive ductal carcinoma on FNAC: A case report Open
The cutaneous metastasis is a late uncommon manifestation of cancer and indicates poor prognosis. The cutaneous metastasis can be a first presentation of underlying malignancy. The FNAC is an easy tool for rapid diagnosis of cutaneous meta…
View article: <i>In vitro</i> activity of bedaquiline and imipenem against actively growing, nutrient-starved, and intracellular <i>Mycobacterium abscessus</i>
<i>In vitro</i> activity of bedaquiline and imipenem against actively growing, nutrient-starved, and intracellular <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus lung disease is difficult to treat due to intrinsic drug resistance and the persistence of drug-tolerant bacteria. Currently, the standard of care is a multi-drug regimen with at least 3 active drugs, preferably inc…
View article: Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection
Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection Open
We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse model of sub-acute Mycobacterium tuberc…
View article: Development of a penem antibiotic against Mycobacteroides abscessus
Development of a penem antibiotic against Mycobacteroides abscessus Open
View article: <i>N</i>-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity
<i>N</i>-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity Open
Herein we demonstrate the expanded utility of a recently described N-trifluoromethylthiolation protocol to sulfonimidamide containing substances. The novel N-trifluoromethylthio sulfonimidamide derivatives thus obtained were …
View article: New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the <i>In Vitro</i> Activity of β-Lactam Antibiotics against Mycobacterium abscessus Complex Clinical Isolates
New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the <i>In Vitro</i> Activity of β-Lactam Antibiotics against Mycobacterium abscessus Complex Clinical Isolates Open
The new diazabicyclooctane-based β-lactamase inhibitors avibactam and relebactam improve the in vitro activity of β-lactam antibiotics against bacteria of the Mycobacterium abscessus complex (MABC). Here, we evaluated the in vitro activiti…
View article: <i>In Vitro</i> Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of <i>Mycobacterium abscessus</i>
<i>In Vitro</i> Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of <i>Mycobacterium abscessus</i> Open
Tigecycline is used in multidrug regimens for salvage therapy of Mycobacterium abscessus infections but is often poorly tolerated and has no oral formulation. Here, we report similar in vitro activity of two newly approved tetracycline ana…
View article: New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the In Vitro Activity of β-Lactam Antibiotics Against <i>Mycobacterium abscessus</i> Complex Clinical Isolates
New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the In Vitro Activity of β-Lactam Antibiotics Against <i>Mycobacterium abscessus</i> Complex Clinical Isolates Open
The new diazabicyclooctane-based β-lactamase inhibitors avibactam and relebactam improve the in vitro activity of β-lactam antibiotics against Mycobacterium abscessus complex (MABC). Here, we evaluated the in vitro activity of two newer di…
View article: Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection
Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection Open
The potent antituberculosis activity and long half-life of bedaquiline make it an attractive candidate for use in long-acting/extended-release formulations for the treatment of latent tuberculosis infection (LTBI). Our objective was to eva…
View article: <i>In Vitro</i> Activity of the New β-Lactamase Inhibitors Relebactam and Vaborbactam in Combination with β-Lactams against Mycobacterium abscessus Complex Clinical Isolates
<i>In Vitro</i> Activity of the New β-Lactamase Inhibitors Relebactam and Vaborbactam in Combination with β-Lactams against Mycobacterium abscessus Complex Clinical Isolates Open
Pulmonary disease due to infection with Mycobacterium abscessus complex (MABC) is notoriously difficult to treat, in large part due to the intrinsic resistance of MABC strains to most antibiotics, including β-lactams. MABC organisms expres…
View article: Activity of a long-acting injectable bedaquiline formulation in a paucibacillary mouse model of latent tuberculosis infection
Activity of a long-acting injectable bedaquiline formulation in a paucibacillary mouse model of latent tuberculosis infection Open
The potent anti-tuberculosis activity and long half-life of bedaquiline make it an attractive candidate for long-acting/extended release formulations for treatment of latent tuberculosis infection (LTBI). Our objective was to evaluate a lo…
View article: Influence of post weld heat treatments on residual stress and mechanical properties of dissimilar welded joint of SS304 and SS202
Influence of post weld heat treatments on residual stress and mechanical properties of dissimilar welded joint of SS304 and SS202 Open
View article: Optimization of process parameters of friction stir welded joint of AA6061 and AA6082 by response surface methodology (RSM)
Optimization of process parameters of friction stir welded joint of AA6061 and AA6082 by response surface methodology (RSM) Open
View article: <i>In vitro</i> activity of the new β-lactamase inhibitors relebactam and vaborbactam in combination with β-lactams against <i>Mycobacterium abscessus</i> complex clinical isolates
<i>In vitro</i> activity of the new β-lactamase inhibitors relebactam and vaborbactam in combination with β-lactams against <i>Mycobacterium abscessus</i> complex clinical isolates Open
Pulmonary disease due to infection with Mycobacterium abscessus complex (MABC) is notoriously difficult to treat, in large part due to MABC’s intrinsic resistance to most antibiotics, including β-lactams. MABC organisms express a broad-spe…