Amit K. Behera
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View article: RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria
RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria Open
SUMMARY Despite progress in understanding pre-mRNA splicing, the regulatory mechanisms controlling most alternative splicing events remain unclear. We developed CRASP-Seq, a method that integrates pooled CRISPR-based genetic perturbations …
View article: Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors
Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors Open
View article: <i>U2AF1 S34F</i>enhances tumorigenic potential of lung cells by exhibiting synergy with<i>KRAS</i>mutation and altering response to environmental stress
<i>U2AF1 S34F</i>enhances tumorigenic potential of lung cells by exhibiting synergy with<i>KRAS</i>mutation and altering response to environmental stress Open
SUMMARY Although U2AF1 S34F is a recurrent splicing factor mutation in lung adenocarcinoma (ADC), U2AF1 S34F alone is insufficient for producing tumors in previous models. Because lung ADCs with U2AF1 S34F frequently have co-occurring KRAS…
View article: Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification Open
View article: Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification Open
The Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. The consortium generated over 427 million long-read sequences from …
View article: Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes
Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes Open
RAS genes are the most frequently mutated oncogenes in cancer, yet the effects of oncogenic RAS signaling on the noncoding transcriptome remain unclear. We analyzed the transcriptomes of human airway and bronchial epithelial cells transfor…
View article: Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification Open
With increased usage of long-read sequencing technologies to perform transcriptome analyses, there becomes a greater need to evaluate different methodologies including library preparation, sequencing platform, and computational analysis to…
View article: Using Multiscale Molecular Dynamics Simulations to Obtain Insights into Pore Forming Toxin Mechanisms
Using Multiscale Molecular Dynamics Simulations to Obtain Insights into Pore Forming Toxin Mechanisms Open
Pore forming toxins (PFTs) are virulent proteins released by several species, including many strains of bacteria, to attack and kill host cells. In this article, we focus on the utility of molecular dynamics (MD) simulations and the molecu…
View article: Functional interplay between YY1 and CARM1 promotes oral carcinogenesis
Functional interplay between YY1 and CARM1 promotes oral carcinogenesis Open
Coactivator associated arginine methyltransferase 1 (CARM1) has been functionally implicated in maintenance of pluripotency, cellular differentiation and tumorigenesis; where it plays regulatory roles by virtue of its ability to coactivate…
View article: p53 mediated regulation of coactivator associated arginine methyltransferase 1 (CARM1) expression is critical for suppression of adipogenesis
p53 mediated regulation of coactivator associated arginine methyltransferase 1 (CARM1) expression is critical for suppression of adipogenesis Open
Coactivator‐associated arginine methyltransferase 1 (CARM1/PRMT4) is a type I arginine methyltransferase that mediates transcriptional activation via methylation of histone H3 on R17, R26, and R42. CARM1 is also a coactivator of transcript…
View article: Molecular Dynamics Simulations Reveal the Role of Membrane Cholesterol during Pore Forming Pathway of Cytolysin A
Molecular Dynamics Simulations Reveal the Role of Membrane Cholesterol during Pore Forming Pathway of Cytolysin A Open