Amit Kumar Pandey
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View article: Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC
Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC Open
Aberrant activation of the Wnt signaling pathway in triple-negative breast cancer (TNBC) is linked to treatment resistance and recurrence, yet its role in tumoral heterogeneity remains unclear. We developed Wnt reporter cell lines from two…
View article: SNHG10 promote tumorigenesis via miR-150/VEGFA/EGFR/AKT/ERK/mTOR axis and gemcitabine resistance in PDAC
SNHG10 promote tumorigenesis via miR-150/VEGFA/EGFR/AKT/ERK/mTOR axis and gemcitabine resistance in PDAC Open
SNHG10 emerged as a key regulator in progression and metastasis of cancers. However, potential of SNHG10 in PDAC tumorigenesis, gemcitabine resistance, and underlying mechanisms remains poorly understood. We observed significant upregulati…
View article: Freedom From Bleeds With Low-Dose Emicizumab Prophylaxis in Inhibitor-Positive Hemophilia A
Freedom From Bleeds With Low-Dose Emicizumab Prophylaxis in Inhibitor-Positive Hemophilia A Open
Emicizumab prophylaxis even in lower doses is effective in preventing bleeds and improving joint outcome in HAI with pre-existing high bleed rate and arthropathy. This opens up an avenue for providing equity in healthcare delivery for HAI …
View article: Solar-Assisted Green Synthesis, Molecular Docking, Antibacterial, and Cytotoxicity Studies of Symmetrical N, N’-Alkylidene Bisamides Bearing Lower E-Factors
Solar-Assisted Green Synthesis, Molecular Docking, Antibacterial, and Cytotoxicity Studies of Symmetrical N, N’-Alkylidene Bisamides Bearing Lower E-Factors Open
N, N'-alkylidene bisamides show promise in biological and pharmaceutical uses. Advanced chemistry now explores cleaner and more environmentally friendly methods. One such method involves using concentrated solar radiation (CSR) to fac…
View article: Editorial: Recent advances in small molecule-based targeted therapy for breast cancer
Editorial: Recent advances in small molecule-based targeted therapy for breast cancer Open
Citation: Htar TT, Naidu R, Lim V and Pandey AK (2023) Editorial: Recent advances in small molecule-based targeted therapy for breast cancer. Front. Pharmacol. 14:1343664. doi: 10.3389/fphar.2023.1343664
View article: Optimization and In Vitro Evaluation of Curcumin-loaded Calcium AlginateMicrobeads using Box-Behnken Design for Colorectal Cancer
Optimization and In Vitro Evaluation of Curcumin-loaded Calcium AlginateMicrobeads using Box-Behnken Design for Colorectal Cancer Open
Background and Objective:: After lung cancer and breast cancer, colorectal cancer (CRC) is the third most common type of cancer and has the second-highest fatality rate. Curcumin is one such naturally occurring dietary compound that demons…
View article: Small-molecule inhibitors of kinases in breast cancer therapy: recent advances, opportunities, and challenges
Small-molecule inhibitors of kinases in breast cancer therapy: recent advances, opportunities, and challenges Open
Breast cancer is the most common malignancy in women worldwide and despite significant advancements in detection, treatment, and management of cancer, it is still the leading cause of malignancy related deaths in women. Understanding the f…
View article: A Prospective Comparative Study of Efficacy of Intralesional Bleomycin Injection with Intralesional 5-FU Injection in Resistant Palmo-Plantar Warts
A Prospective Comparative Study of Efficacy of Intralesional Bleomycin Injection with Intralesional 5-FU Injection in Resistant Palmo-Plantar Warts Open
Background: Treating of recalcitrant viral verrucae either individually or in combination is inconvenient and frustrating both for patients and treating physician. There is no treatment, which is 100% effective for warts. Objectives: To co…
View article: A comparative study of narrowband-ultraviolet B plus intralesional normal saline versus narrowband-ultraviolet B with platelet rich plasma in treatment of vitiligo
A comparative study of narrowband-ultraviolet B plus intralesional normal saline versus narrowband-ultraviolet B with platelet rich plasma in treatment of vitiligo Open
Background: Treatment of vitiligo remains a challenge and there is no universal consensus about optimal treatment. Platelet rich plasma contains several growth factors and is being used as an effective treatment of several dermatological d…
View article: Role of Artificial Intelligence in Municipal Solid Waste Management
Role of Artificial Intelligence in Municipal Solid Waste Management Open
Waste management incorporates technological, climatic, environmental, and demographic concerns. Socio economic, legal aspects. Traditional methodologies struggle to analyze, predict, and enhance such complex linear processes. Artificial in…
View article: Expression of miR-145 and miR-18b in Peripheral Blood Samples of Head and Neck Cancer Patients
Expression of miR-145 and miR-18b in Peripheral Blood Samples of Head and Neck Cancer Patients Open
View article: miRNA therapeutics in precision oncology: a natural premium to nurture
miRNA therapeutics in precision oncology: a natural premium to nurture Open
The dynamic spectrum of microRNA (miRNA) has grown significantly over the years with its identification and exploration in cancer therapeutics and is currently identified as an important resource for innovative strategies due to its functi…
View article: Synthesis of a Zirconium Complex of an <i>N</i>,<i>O</i>-type <i>p</i>-<i>tert</i>-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions
Synthesis of a Zirconium Complex of an <i>N</i>,<i>O</i>-type <i>p</i>-<i>tert</i>-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions Open
The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the p…
View article: STUDY OF MUNICIPAL SOLID WASTE MANAGEMENT IN RANCHI, JHARKHAND
STUDY OF MUNICIPAL SOLID WASTE MANAGEMENT IN RANCHI, JHARKHAND Open
Solid waste management (SWM) have becomes a very serious concern globally. The lack of individual responsibilities as well as proper attitude and approach leads to this issue. Rapid industrialization, increase in population and further inc…
View article: Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade
Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade Open
View article: Overexpression of Laminin-5 Gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade
Overexpression of Laminin-5 Gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade Open
Pancreatic ductal adenocarcinoma (PDAC) is correlated with poor outcomes because of limited therapeutic options. Laminin-5 Gamma-2 (LAMC2) plays a critical role in key biological processes. However, the detailed molecular mechanism and pot…
View article: Phacomatosis pigmentovascularis: a rare case report
Phacomatosis pigmentovascularis: a rare case report Open
Phacomatosis pigmentovascularis is a rare group of syndromes characterized by the co-existence of a vascular nevus and a pigmentary nevus with or without extracutaneous systemic involvement. The existing classifications of phacomatosis pig…
View article: To Study the Incidences of Anxiety and Depression in Patients Diagnosed with Obstructive Sleep Apnea (OSA) and Population Without Obstructive Sleep Apnea
To Study the Incidences of Anxiety and Depression in Patients Diagnosed with Obstructive Sleep Apnea (OSA) and Population Without Obstructive Sleep Apnea Open
View article: LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics Open
Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory fu…
View article: Effect of integrated nutrient management on particle size distribution of calcareous soil
Effect of integrated nutrient management on particle size distribution of calcareous soil Open
To assess the impact of organics and chemical fertilizer on particle size distribution in calcareous soil, a field experiment was conducted at Dr. Rajendra Prasad Central Agricultural University, Pusa, Bihar. The experiment was laid out in…
View article: A Revolution in Health Care Sector Through Data Sciences
A Revolution in Health Care Sector Through Data Sciences Open
Healthcare industry is undergoing a digital transformation. There is lot of work which is happening thatleverages the newer technologies in the healthcare industry. Technological advancements will be driverfor change for future ready healt…
View article: A brief overview of antitumoral actions of bruceine D
A brief overview of antitumoral actions of bruceine D Open
Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that…
View article: Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer
Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC), with a significant disease burden worldwide. Chemoresistance and lack of targeted therapeutics are major hindrances to effective treatments in the …
View article: Successful treatment of POEMS syndrome in a young male with stem cell transplantation
Successful treatment of POEMS syndrome in a young male with stem cell transplantation Open
POEMs syndrome is a rare paraneoplastic disorder related to plasma cell dyscrasia. The present study deals with an unusual case of POEMs syndrome in a young male who came with ascending demyelinating polyneuropathy, resulting in complete q…
View article: Deciphering the Mounting Complexity of the p53 Regulatory Network in Correlation to Long Non-Coding RNAs (lncRNAs) in Ovarian Cancer
Deciphering the Mounting Complexity of the p53 Regulatory Network in Correlation to Long Non-Coding RNAs (lncRNAs) in Ovarian Cancer Open
Amongst the various gynecological malignancies affecting female health globally, ovarian cancer is one of the predominant and lethal among all. The identification and functional characterization of long non-coding RNAs (lncRNAs) are made p…
View article: SHIFTING TO CONTAINERIZED DEVELOPMENT IN ORGANIZATIONS WITH CLOUD-SUPPORTED INFRASTRUCTURE
SHIFTING TO CONTAINERIZED DEVELOPMENT IN ORGANIZATIONS WITH CLOUD-SUPPORTED INFRASTRUCTURE Open
Containerization is a new approach in developing and hosting applications; it allows running multiple applications on the same virtual machine, instead of virtualizing the entire operating system.It finds an unusually high level of accepta…
View article: Role of different topical modalities in improvement of facial hyperpigmentation and skin rejuvenation
Role of different topical modalities in improvement of facial hyperpigmentation and skin rejuvenation Open
Background: Facial hypermelanosis is a psychologically stressful condition for modern men and women who are cosmetically more conscious than their ancestors. There are various lightening agent used for several months befor…
View article: A comparative study of effectiveness of autologus serum therapy with oral antihistamines versus oral methotrexate and oral antihistamines in chronic urticaria patients
A comparative study of effectiveness of autologus serum therapy with oral antihistamines versus oral methotrexate and oral antihistamines in chronic urticaria patients Open
Background: Chronic urticaria (CU) is a worrisome problem and patients of CU suffer from the morbidity that arises from irritable itch thus they are subjected to a huge antihistamine pill burden. The symptoms are more prom…
View article: Association of psoriasis with metabolic disorders and their assessment using epicardial fat thickness, serum lipid profile and homocysteine level
Association of psoriasis with metabolic disorders and their assessment using epicardial fat thickness, serum lipid profile and homocysteine level Open
Background: Psoriasis is a chronic immune-mediated inflammatory disease with worldwide prevalence of 2-4%. It is characterized by sharply demarcated erythematous plaque lesions with silvery white scales. A number of litera…
View article: THE IMPACT OF A COMPREHENSIVE HEART FAILURE MANAGEMENT PROGRAM INCLUDING PHARMACOLOGICAL OPTIMIZATION WITH VALSARTAN/SACUBITRIL ON CARDIAC FUNCTION AND FUNCTIONAL CAPACITY IN REDUCED EJECTION FRACTION HEART FAILURE
THE IMPACT OF A COMPREHENSIVE HEART FAILURE MANAGEMENT PROGRAM INCLUDING PHARMACOLOGICAL OPTIMIZATION WITH VALSARTAN/SACUBITRIL ON CARDIAC FUNCTION AND FUNCTIONAL CAPACITY IN REDUCED EJECTION FRACTION HEART FAILURE Open