Amit N. Khachane
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View article: Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia
Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia Open
Neurocognitive deficits are a core feature of schizophrenia and, therefore, represent potentially critical outcome variables for assessing antipsychotic treatment response. We performed genome-wide association studies (GWAS) with 492K sing…
View article: Methylome-Wide Association Study of Schizophrenia: Identifying Blood Biomarker Signatures of Environmental Insults
Methylome-Wide Association Study of Schizophrenia: Identifying Blood Biomarker Signatures of Environmental Insults Open
Epigenetic studies present unique opportunities to advance schizophrenia research because they can potentially account for many of its clinical features and suggest novel strategies to improve disease management.
View article: A Comprehensive Family-Based Replication Study of Schizophrenia Genes
A Comprehensive Family-Based Replication Study of Schizophrenia Genes Open
Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is critical to improve disease understanding and address the urgent need for new drug ta…
View article: The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae
The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae Open
Background Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental ba…
View article: It is elemental: soil nutrient stoichiometry drives bacterial diversity
It is elemental: soil nutrient stoichiometry drives bacterial diversity Open
Summary It is well established that resource quantity and elemental stoichiometry play major roles in shaping below and aboveground plant biodiversity, but their importance for shaping microbial diversity in soil remains unclear. Here, we …
View article: The Role of Microbial Community Composition in Controlling Soil Respiration Responses to Temperature
The Role of Microbial Community Composition in Controlling Soil Respiration Responses to Temperature Open
Rising global temperatures may increase the rates of soil organic matter decomposition by heterotrophic microorganisms, potentially accelerating climate change further by releasing additional carbon dioxide (CO2) to the atmosphere. However…
View article: Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning
Lack of functional redundancy in the relationship between microbial diversity and ecosystem functioning Open
Summary Biodiversity is declining world‐wide with detrimental effects on ecosystems. However, we lack a quantitative understanding of the shape of the relationship between microbial biodiversity and ecosystem function ( BEF ). This limits …