Explanipedia

Oral delivery of transferrin coated rivastigmine microspheres for Alzheimer’s disease therapy Open

Omkar Khaire, Kailash Ahirwar, Ajit Singh, Rahul Shukla, S.J.S. Flora · 2025

Comparative Functional Assessment of Proximal Femoral Nail (PFN) and Cemented Bipolar Hemiarthroplasty in Hip Fracture Patients Open

R. P. Nagar, Siddharth Sagar, Ajit Singh, Mani Bagga · 2025

Oral Delivery of Transferrin Coated Rivastigmine Microspheres for Alzheimer’s Disease Therapy Open

Omkar Khaire, Kailash Ahirwar, Ajit Singh, Rahul Shukla, S.J.S. Flora · 2025

Rivastigmine hydrogen tartrate (RHT) is a first-line drug used for Alzheimer’s disease treatment. But RHT has high solubility and gastric hurdles which interfere with its bioavailability profile via oral route. To overcomes these issue RHT…

Outcome for AI Tools Being Allowed for JEE Exams Open

Ajit Singh · 2025

Evaluation of apple cv. Jeromine raised on in vitro and conventionally propagated clonal apple rootstocks Open

Ajit Singh, Manju Modgil, Madhurjit Singh Rathore, Pramod Kumar Verma, Pooja Sharma , et al. · 2024

Apple is a significant cash crop that is cultivated in the temperate areas around the globe. In the past, seedling rootstocks were used for raising commercial apple orchards however, the increasing demand for apple has led to a rising inte…

Fishbone Foreign Body Ingestion With Gastric Impaction and Intestinal Micro-perforation in an Adult Female: A Case Report Open

D Dupont, Louis Maria Umejiego, Savni Satoskar, N Soumya, Monique Freire Santana , et al. · 2024

Role of Conservation Tillage Practices in Sustainable Agricultural Systems Open

Bhim Singh, Ajit Singh, Dhanashri Sanadkumar Havale, Nagendra Kumar Singh, M. A. Rashmi , et al. · 2024

Finding sustainable land management techniques is urgently needed to balance food supply with the growing global population. Nonetheless, the battle to attain food security needs to be waged with consideration for the environment in which …

Climate Resilient Agriculture: Enhancing Agricultural Sustainability in the Face of Climate Change Scenario Open

Chinmoy Deori, Pratishruti Behera, Anjan Sharma, Mriganko Kakoti, Juman Das , et al. · 2024

The increasing demands of a growing population pose a serious danger to global food and nutritional security due to the detrimental impacts of climate change on crop growth and agricultural production, both in terms of quantity and quality…

Therapeutic effect of omega-3 fatty acid in polycystic ovarian disease Open

Archana Yadav, Anand Mishra, Akanksha Sharma, V. Harsha, Ajit Singh , et al. · 2024

Polycystic ovarian disease is the most common endocrine condition in reproductive-aged women. Its common characteristics are reproductive, metabolic, endocrine, and psychological changes in women. We review here the therapeutic effect of o…

Review of: "[Case Report] Ramipril-Induced Angioedema in a Patient With Basal Ganglia Bleed: A Case Report" Open

Ajit Singh · 2024

Potential competing interests: No potential competing interests to declare.The case report is written well, but the authors should also rule out angioedema caused by amiodarone and look deeper into drug-drug interactions.The case report, "…

Use of Indocyanine Green to Detect Intraoperative Staple-Line Leaks in Robotic Bariatric Surgery: An Observational Cohort Study Open

Muzi Meng, Jaskaran Singh Saini, David Fan, Ajit Singh, Daniel T. Farkas · 2024

Background Bariatric surgeries aid weight loss in patients with morbid obesity, yet staple-line leaks pose safety concerns. Multiple methods are used to help identify these links. Intraluminal indocyanine green (ICG) has been shown to be u…

The Efficacy of Intraoperative Esophagogastroduodenoscopy in Localizing Retroperitoneal Bowel Injury: A Case Report Open

Muzi Meng, Cesar Riera Gonzalez, Yonas Teklu, Jorge Mosquera Zavaleta, Ajit Singh · 2024

Morphometric analysis of coracoid process and glenoid width -3D CT Open

Ajit Singh · 2024

Aim-The purpose of this study was to use 3D CT to examine the morphometric parameters in the glenoid width and coracoid process in the UP western population. Objective - Using morphometric parameter shows difference according to age and ge…

A rare case of MRSA associated Lemierre’s syndrome Open

Olivia Mobarakai, Sofia Barrios, Ajit Singh, J. P. Stone · 2024

Lemierre's syndrome, or postanginal sepsis, is an uncommon but potentially fatal infection of the internal jugular vein. The combination of bacteremia, internal jugular vein thrombophlebitis, and metastatic septic emboli secondary to acute…

Molecular detection of pathogenic bacteria in bovine milk samples collected from local vendors in Jabalpur Open

Bikash Ranjan Prusty, Ajit Singh, Jhanak Chaveriya, Kush Shrivastava, Tripti Jain · 2024

Milk provides essential nutrients for growth but also serves as a medium for various microbial growth. The milk gets contaminated with some pathogenic microbes, either from infected udder or due to poor milking practices like uncleaned udd…

Genome editing for indigenous poultry conservation: Possibilities for developing Nations Open

Jhanak Cyahaveri, Ajit Singh, Kush Shrivastava, Tripti Jain, Bikash Ranjan Prusty , et al. · 2024

Poultry is one of the major sources of protein for human nutrition. They are domesticated for meat, eggs, and feathers. Rapid centralization, commercialization, and research developments in the poultry sector, have paved the way for the pr…

Prevalence of Thyroid Disorders among Pregnant Women at Birat Medical College Teaching Hospital Open

Raj Deb Mahato, Ajit Singh, Manisha Joshi, Tarun Pradhan, Sujeet Kumar Singh , et al. · 2023

Background: Thyroid disorders (TD) are the second most common endocrine disorders seen in pregnancy. TD is known to be associated with adverse maternal and fetal outcomes. Materials and Methods: This was a hospital based descriptive cross-…

A Complicated Case of Strangulated Inguinal Hernia of the Sigmoid Colon With Secondary Ischemic-Compromise of Scrotal Tissue: A Multi-Disciplinary Surgical Approach Open

Muzi Meng, Yonas Teklu, Harsh R. Parikh, Gagan Sathya Prakash, Joseph Silletti , et al. · 2023

Atypical diffuse large B-cell lymphoma, primary splenic lymphoma variant; a case report Open

Muzi Meng, Cesar A. Riera, Jorge Mosquera, Harsh R. Parikh, Ajit Singh · 2023

Primary Splenic DLBCL, an exceptionally rare B-Cell neoplasm variant, requires precise diagnosis due to its unique splenic involvement. Splenectomy's efficacy, adjuvant therapy, multidisciplinary collaboration, and ongoing research are cru…

CLINICAL PROFILE AND TREATMENT RESPONSE TO SOFOSBUVIR-VELPATASVIR REGIMEN AND ITS IMPACT ON THE QUALITY OF LIFE IN CHRONIC HEPATITIS C PATIENTS Open

Ajit Singh, Pankaj Asati, KANISHK YADAV · 2023

Objective: Chronic Hepatitis C infection is one of the major global contributors to liver-related morbidity and mortality. Successful antiviral therapy with the direct-acting antiviral combination sofosbuvir-velpatasvir has shown to improv…

Characterization of Foot-and-Mouth Disease Virus Serotype O-Specific Single Domain Antibody Expressed in the pET Expression System Open

Vijay Kumar, Swati Dahiya, Savita Budania, Akhil Kumar Gupta, Punesh Sangwan , et al. · 2023

Vincristine-based nanoformulations: a preclinical and clinical studies overview Open

Rahul Shukla, Ajit Singh, Kamalinder K. Singh · 2023

Factor Responsible for Surgical Site Infection Following Emergency Non-Traumatic Abdominal Surgery Open

Aditya Prakash Yadav, Chandrika Sah Rauniyar, Manisha Joshi, Ajit Singh, B Shrestha · 2023

Introduction: Surgical Site Infection (SSI) have always been a major complication of surgery. It results from microbialinfection during or after the surgical procedure. According to CDC, SSI can be classified as superficial,deep and organ/…

Risk Factors associated with Intrauterine Fetal Death at Birat Medical College Teaching Hospital Open

Raj Deb Mahato, Ajit Singh, Binish Man Shrestha, Manisha Joshi, Sujeet Kumar Singh , et al. · 2023

Background & Objective: Intrauterine fetal death is a tragic event, and despite efforts to reduce its incidence, it remains challenging to do so. Intrauterine fetal death is an important indicator of the maternal and perinatal health of a …

Expression Pattern of SLIT 2 Genes Discriminates Malignant from Benign Canine Mammary Tumours Open

Sandeep Saharan, Prem Singh, Ajit Singh, Rajendra P. Gupta, Ravi Dutt · 2023

The study was conducted to investigate the expression of SLIT2 gene in representative tissue samples of mammary tumours of female dogs (n=10) with the age between 5.0 and 16.5 years brought to Veterinary Clinical Complex, LUVAS, Hisar. Exc…

Clinical features and haematological parameters associated with COVID-19 severity among hospitalized patients: A retrospective observational study from Tribal Central India Open

Vikrant Kabirpanthi, Vikas Gupta, Ajit Singh · 2022

A BSTRACT Background: Reports describing demographics, clinical characteristics, hospital course, morbidity, and mortality in patients in the Indian setting have been published, but they are based on limited numbers of cases. The present s…

<i>Trypanosoma evansi</i> RoTat 1.2 variant surface antigen mimotopes selected by panning of the random peptide phage‐display library against monoclonal antibodies Open

Savita Budania, Abhishek Dubey, Ajit Singh · 2022

Mimotope peptides of native antigens are valuable for diverse applications such as diagnostics, therapeutics and modern vaccine design. Here, we report for the first time the selection and identification of peptide mimotopes of Trypanosoma…

Potential of particle size less than 15 nm via olfactory region for direct brain delivery via intranasal route Open

Mayank Handa, Ajit Singh, Dheeraj Bisht, Prashant Kesharwani, Rahul Shukla · 2022

Central nervous system-related disorders are very difficult to manage with conventional therapeutics because of the selective and herculean nature of the blood-brain barrier which does not allow easy penetration of drug molecules into the …

Comparison of parasitological, serological and molecular diagnostic tests for detection of subclinical Trypanosomosis in two organised dairy herds Open

Gaurav Charaya, N. K. Rakha, Aman Kumar, Akhil Kumar Gupta, Sushila Maan , et al. · 2022

Trypanosomosis also known as ‘Surra’ caused by Trypanosoma evansi is of significant economic importance in livestock production. Diagnosis of subclinical infection and carrier state of disease is far difficult. Therefore, the present study…

Formulation development of tocopherol polyethylene glycol nanoengineered polyamidoamine dendrimer for neuroprotection and treatment of Alzheimer disease Open

Ajit Singh, Rewati Raman Ujjwal, Saba Naqvi, Rahul Kumar Verma, Sanjay Tiwari , et al. · 2022

Amyloid-beta (Aβ) aggregates deposition at extra neuronal sites induces neurotoxicity and major hallmarks of Alzheimer’s disease (AD). To reduce the Aβ fibril toxicity, multi-functional polyamidoamine (PAMAM) dendrimer was conjugated with …

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