Explanipedia

Visible precipitation upon mixing dexamethasone and bupivacaine for a peripheral nerve block: A case report Open

Chitta Ranjan Mohanty, Amiya Kumar Barik, Rakesh Vadakkethil Radhakrishnan, Ananya Ray, Amit Rout · 2025

The compatibility of local anaesthetics (LA) with adjuvants is critical for safe peripheral nerve blocks. Previous reports have highlighted turbidity and precipitation when ropivacaine was mixed with dexamethasone; bupivacaine–dexamethason…

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infection Open

Anshula Sharma, Chandru Subramani, Shouri KA, Ghanshyam Sharma, Brohmomoy Basu , et al. · 2025

Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes frequent epidemics of chikungunya fever across the world and has become a significant medical challenge, warranting the development of novel antivirals. A cell imaging-based hi…

Results of Minimally Invasive Core Decompression and Autologous Bone Grafting in Combination with Autologous Bone Marrow Aspirate Concentrate in the Treatment of Patients with Aseptic Osteonecrosis of the Femoral Head Open

Amit Rout, Sunil Kumar Dash, N. Panigrahi · 2025

Hybrid Cloud-Integrated and GAN-Based Deep Learning Framework for Prediction of Environmental Time Series Open

Amit Rout, Biswa Ranjan Senapati, Debahuti Mishra · 2025

Cloud-Integrated Meteorological Parameter Prediction by Leveraging Multivariate Statistical Time Series and GANs Open

Amit Rout, Biswa Ranjan Senapati, Debahuti Mishra · 2024

Meteorological parameters are increasingly influenced by unsustainable development and environmental pollution, contributing to the rising frequency of natural calamities. Accurate prediction of these parameters is crucial for prevention. …

Meteorological Parameter Prediction: A Comprehensive Review of Statistical, Machine Learning, and Deep Learning Approaches Open

Amit Rout, Biswa Ranjan Senapati, Debahuti Mishra · 2024

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection Open

Kiran Bala Sharma, Chandru Subramani, Ganesh Kondabattula, Anshula Sharma, Brohmomoy Basu , et al. · 2024

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus causing fever, myalgia, and debilitating joint swelling and pain, which in many patients becomes chronic. The frequent epidemics of CHIKV across the world pose a significant pu…

Invasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non–ST‐segment–Elevation Acute Coronary Syndrome: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Open

Amit Rout, Mohamad Bahij Moumneh, Kriti Kalra, Sahib Singh, Aakash Garg , et al. · 2024

Background Older adults with non–ST‐segment–elevation acute coronary syndrome are less likely to undergo an invasive strategy compared with younger patients. Randomized controlled trials traditionally exclude older adults because of their …

Auto-delineation of the hippocampus using Mask R-CNN for radiation oncology: A cross-sectional observational study Open

Adwait Laud, Kaustav Talapatra, Manoj Sankhe, Ajinkya Gupte, Ashish Shetty , et al. · 2024

Objective: Radiotherapy is an effective treatment for brain tumors, but it can lead to adverse side effects, particularly neurocognitive dysfunction. The hippocampus, a crucial structure for memory formation, is vulnerable to radiation-ind…

A-66 | Thrombolytics Assisted Invasive Approach versus Primary Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction: An Updated Meta-Analysis of Randomized Controlled Trials Open

Mounica Vorla, Amit Rout, Sanchit Duhan, Sahib Singh, Sarabjeet Singh Suri , et al. · 2024

Primary Percutaneous Intervention (PPCI) is preferred strategy for reperfusion in STEMI management. Logistical barriers limit the availability and optimal timing of PPCI. Alternative approach includes use of thrombolytics assisted invasive…

Meta-analysis depicting the outcomes of hypothermia versus normothermia post cardiac arrest Open

Sanchit Duhan, Bijeta Keisham, Sarabjeet Singh, Ahmed Taha, Harigopal Sandhyavenu , et al. · 2023

Background The current American Heart Association (AHA) 2020 guidelines recommend targeted temperature monitoring (TTM) for cardiac arrest patients. However, more recently published trials intrigued us to review the therapeutic benefit of …

Ruptured Noncoronary Sinus of Valsalva Aneurysm Presenting As Sudden Onset Heart Failure Open

Amit Rout, Vivek Lohana, Muhammad Omer Zaman · 2023

Sinus of Valsalva Aneurysm (SOVA) is a rare congenital or acquired cardiac anomaly. SOVA can remain undiagnosed till it ruptures and can present as acute heart failure, acute coronary syndrome or cardiac tamponade [1]. The aneurysm usually…

Meta-analysis of immediate complete vs staged complete revascularization in patients with acute coronary syndrome and multivessel disease Open

Sahib Singh, Aakash Garg, Rahul Chaudhary, Amit Rout, Udaya S. Tantry , et al. · 2023

Oxygen Targets After Cardiac Arrest: A Meta-analysis of Randomized Controlled Trials Open

Sahib Singh, Amit Rout, Rahul Chaudhary, Aakash Garg, Udaya S. Tantry , et al. · 2023

Background: Optimal oxygen saturation target in patients resuscitated after cardiac arrest is unknown. Previous randomized controlled trials (RCTs) comparing restrictive oxygen therapy with liberal therapy have shown conflicting results. S…

Renal denervation in hypertension: An updated meta‐analysis of the randomized controlled trials Open

Sahib Singh, Amit Rout, Aakash Garg · 2023

Background Radiofrequency or ultrasound renal denervation (RDN) has shown conflicting results when used as an adjunctive option for hypertension management in randomized controlled trials (RCTs). Methods We searched Pubmed, MEDLINE, and ot…

A Rapidly Growing Cardiac Mass—Malignant or Benign? Open

Amit Rout, Mounica Vorla, Afolasayo A. Aromiwura, Siddharth Pahwa, Marcus F. Stoddard , et al. · 2023

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C-17 | Efficacy of Pulmonary Artery Denervation Therapy for the Treatment of Pulmonary Artery Hypertension Open

Mounica Vorla, Dipsa Shastri, Amit Rout, Sarabjeet Singh Suri, Prashil Dave , et al. · 2023

Despite making advances in the vasodilator therapy, pulmonary arterial hypertension (PAH) remains one of the main causes of morbidity and mortality. Pulmonary artery denervation (PADN) is a novel therapy for PAH; however, its efficacy and …

Myocarditis associated with COVID-19 and its vaccines - a systematic review Open

Amit Rout, Sarabjeet Singh Suri, Mounica Vorla, Dinesh Kalra · 2022

Monitoring and Reversal of Anticoagulation and Antiplatelet Agents Open

Paul A. Gurbel, Amit Rout, Udaya S. Tantry · 2022

Mean Arterial Pressure Goal in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials Open

Sauradeep Sarkar, Sahib Singh, Amit Rout · 2022

In critically ill patients, a higher MAP goal of > 70 mm Hg was associated with a similar risk of mortality, duration of mechanical ventilation, and ICU length of stay when compared with a standard MAP goal of 60 - 70 mm Hg.

Vitamin D Supplementation in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials Open

Sahib Singh, Sauradeep Sarkar, Kushagra Gupta, Amit Rout · 2022

TREATMENT DILEMMA: AORTIC DISSECTION CAUSING STROKE, ACUTE CORONARY SYNDROME, AND COAGULOPATHY Open

Sahib Singh, Amit Rout, Adrian Sarzynski · 2021

Predicting if Lung Cancer Will Relapse–The Role of Neutrophil/Lymphocyte Ratio Open

Abigail Chan, Søren M. Bentzen, Amit Rout, Kenneth Miller · 2021

Objective/Background: Baseline neutrophil/lymphocyte ratio (NLR), a surrogate marker for systemic inflammation and immunosuppression, is a well-studied prognostic marker in non-small cell lung cancer (NSCLC). This study tests if interim NL…

BRASH: Case Report and Review of Literature Open

Sauradeep Sarkar, Nicole Rapista, Amit Rout, Rahul Chaudhary · 2021

BRASH syndrome is characterized by bradycardia, renal failure, AV nodal blockade, shock, and hyperkalemia. The proposed mechanism involves a vicious cycle between AV nodal blockers, hyperkalemia, and renal failure and was first described i…

Bedside thromboelastography to rapidly assess the pharmacodynamic response of anticoagulants and aspirin in COVID-19: evidence of inadequate therapy in a predominantly minority population Open

Paul A. Gurbel, Kevin P. Bliden, Amit Rout, Nicole Rapista, Naval Walia , et al. · 2021

Is a personalized pharmacotherapeutic approach closed for acute coronary syndrome? Open

Udaya S. Tantry, Amit Rout, Kevin P. Bliden, Paul A. Gurbel · 2021

Improvement in reperfusion and pharmacotherapy strategies for the acute coronary syndrome (ACS) had led to a decline in mortality and morbidity; despite this ACS is still associated with substantia...

Abernethy Malformation with Massively Dilated Main Pulmonary Artery Manifesting as Acute Myocardial Infarction Open

Amit Rout, Vasutakarn Chongthammakun, Yoel Siegel, Damian Mendoza, Abdulla A. Damluji · 2021

MEAN ARTERIAL PRESSURE GOAL IN CRITICALLY ILL MEDICAL PATIENTS: A METANALYSIS OF RANDOMIZED CONTROLLED TRIALS Open

Sauradeep Sarkar, Sahib Singh, Amit Rout · 2020

ASPERGILLUS FUMIGATUS EMPYEMA IN AN IMMUNOCOMPROMISED PATIENT WITH RHEUMATOID ARTHRITIS Open

Sahib Singh, Amit Rout, Adrian Sarzynski · 2020

ROLE OF VITAMIN D SUPPLEMENTATION IN CRITICALLY ILL PATIENTS: AN UPDATED META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS Open

Sahib Singh, Amit Rout, Sauradeep Sarkar · 2020

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