Amitava Chakrabarti
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View article: Retraction Notice: Anti-kindling Effect of Bezafibrate, a Peroxisome Proliferator-activated Receptors Alpha Agonist, in Pentylenetetrazole Induced Kindling Seizure Model
Retraction Notice: Anti-kindling Effect of Bezafibrate, a Peroxisome Proliferator-activated Receptors Alpha Agonist, in Pentylenetetrazole Induced Kindling Seizure Model Open
View article: Repurposing bicalutamide as a potential inhibitor of MMP13 for osteoarthritis treatment
Repurposing bicalutamide as a potential inhibitor of MMP13 for osteoarthritis treatment Open
View article: Over-the-counter drug development in developing countries
Over-the-counter drug development in developing countries Open
View article: Genetic Association in the Pathophysiology of Degenerative Cervical Disc Disease: Defining Roles?
Genetic Association in the Pathophysiology of Degenerative Cervical Disc Disease: Defining Roles? Open
Degenerative cervical myelopathy (DCM), encompassing cervical spondylotic myelopathy and posterior longitudinal ligament ossification, is now being documented frequently and significantly burdening the health care systems. The pathogenesis…
View article: Study of fingolimod, nitric oxide inhibitor, and P-glycoprotein inhibitor in modulating the P-glycoprotein expression via an endothelin–sphingolipid pathway in an animal model of pharmacoresistant epilepsy
Study of fingolimod, nitric oxide inhibitor, and P-glycoprotein inhibitor in modulating the P-glycoprotein expression via an endothelin–sphingolipid pathway in an animal model of pharmacoresistant epilepsy Open
BACKGROUND: The overexpression of P-glycoprotein (P-gp) contributes to drug resistance in patients with epilepsy, and the change of P-gp expression located at the blood–brain barrier alienates the anti-seizure effects of P-gp substrates. T…
View article: Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway
Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway Open
Brain Insulin-resistance plays a critical role in pathogenesis of Alzheimer's disease (AD). Current study explored the therapeutic mechanism of metformin (insulin sensitizer) and its solid-lipid nanoformulation (SLN) in rat-model of AD. In…
View article: Translational research
Translational research Open
Drug discovery and development are lengthy and expensive process that takes nearly 10–15 years with an average amount of more than $1–2 billion for the approval of every novel drug for clinical use.[1] Nonclinical studies are generally par…
View article: Imaging techniques in drug development
Imaging techniques in drug development Open
Introduction The process of drug discovery and development is a risky, lengthy, and resource-intensive endeavor; both in terms of the cost and time, it takes for a single new molecule to enter the market. For most new chemical entities (NC…
View article: Pentylenetetrazole Induced Kindling Model of Refractory Epilepsy: A Proof-of-concept Study to Explore Dose and Time Range of Phenobarbital in Rats
Pentylenetetrazole Induced Kindling Model of Refractory Epilepsy: A Proof-of-concept Study to Explore Dose and Time Range of Phenobarbital in Rats Open
Introduction: Drug-resistant epilepsy is an unmet medical condition that impacts 30% of epileptic patients. Numerous antiseizure drugs have already been developed but they provide only symptomatic relief and do not target the underlying pa…
View article: Social Pharmacology and its impact on clinics
Social Pharmacology and its impact on clinics Open
View article: Neuroprotective Effect of Celastrus Paniculatus Seed Extract on Epilepsy and Epilepsy-associated Cognitive Deficits
Neuroprotective Effect of Celastrus Paniculatus Seed Extract on Epilepsy and Epilepsy-associated Cognitive Deficits Open
Introduction: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of Celastrus paniculatus seed extract on seizure severity and cognitive deficit following the pentylenetetrazole…
View article: Novel Therapeutic Mechanism of Action of Metformin and Its Nanoformulation in Alzheimer's Disease and Role of AKT/ERK/GSK Pathway.
Novel Therapeutic Mechanism of Action of Metformin and Its Nanoformulation in Alzheimer's Disease and Role of AKT/ERK/GSK Pathway. Open
Background: Insulin resistance in brain plays a critical role in the pathogenesis of Alzheimer's disease (AD). Metformin is a blood brain barrier crossing anti-diabetic insulin-sensitizer drug. Current study has evaluated the therapeutic a…
View article: To study the effect and mechanism of dimethyl fumarate [DMF] in adjuvant induced arthritis model in rats
To study the effect and mechanism of dimethyl fumarate [DMF] in adjuvant induced arthritis model in rats Open
Currently available disease modifying anti-rheumatoid drugs have limitations like dose-dependent toxicity and tolerance.Dimethyl fumarate has demonstrated anti-inflammatory and immunomodulatory properties in various animal models. Thus, th…
View article: P3‐070: THERAPEUTIC ROLE OF METFORMIN IN PRECLINICAL Aβ(1‐42) INDUCED RAT MODELS OF ALZHEIMER'S DISEASE
P3‐070: THERAPEUTIC ROLE OF METFORMIN IN PRECLINICAL Aβ(1‐42) INDUCED RAT MODELS OF ALZHEIMER'S DISEASE Open
Alzheimer's disease is a progressive neurodegenerative disease. Brain insulin resistance plays an important role in the pathogenesis of AD. Metformin is an insulin sensitizer and is indicated in the treatment of type 2 diabetes mellitus. I…
View article: P2‐075: THERAPEUTIC MECHANISM OF METFORMIN IN STREPTOZOTOCIN INDUCED RAT MODELS OF ALZHEIMER'S DISEASE
P2‐075: THERAPEUTIC MECHANISM OF METFORMIN IN STREPTOZOTOCIN INDUCED RAT MODELS OF ALZHEIMER'S DISEASE Open
Alzheimer's disease is a neurodegenerative disease. State of insulin resistance in brain and Type-II diabetes mellitus can increases the risk of Alzheimer's disease. Metformin is commonly used oral antidiabetic drug in type-II diabetes, wh…
View article: P844 Mucosa associated candida in ulcerative colitis: prevalence and relationship to disease severity
P844 Mucosa associated candida in ulcerative colitis: prevalence and relationship to disease severity Open
Role of fungal dysbiosis in pathogenesis and severity of ulcerative colitis (UC) is not known. We planned to determine the relationship of presence, nature and quantify Mucosa Associated Candida (MAC) with the disease severity in patients …
View article: Study of nuclear factor-2 erythroid related factor-2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats
Study of nuclear factor-2 erythroid related factor-2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats Open
Objectives The role of nuclear factor-2 erythroid related factor-2 (Nrf2) activator, berberine (BBR), has been established in rat model of streptozotocin induced diabetic neuropathy. Around 30–40% of cancer patients, on paclitaxel (PTX) ch…
View article: Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial
Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial Open
View article: Anti-Oxidant and Anti-Apoptotic Effects of Berberine in Pentylenetetrazole-Induced Kindling Model in Rat
Anti-Oxidant and Anti-Apoptotic Effects of Berberine in Pentylenetetrazole-Induced Kindling Model in Rat Open
The present study demonstrated the anti-epileptogenic effect of BBR, which may be due to antioxidant and anti-apoptotic properties of the PTZ-induced kindling model of epilepsy.
View article: To study the anti-hyperalgesic and anti-allodynic effects of Atorvastatin and Low Dose Naltrexone in Vincristine Induced Peripheral Neuropathic Pain Model in Rats
To study the anti-hyperalgesic and anti-allodynic effects of Atorvastatin and Low Dose Naltrexone in Vincristine Induced Peripheral Neuropathic Pain Model in Rats Open
Background: Peripheral neuropathy is a common adverse effect of anticancer drugs like vincristine and paclitaxel. Current pharmacotherapy for this type of neuropathic pain is unsatisfactory.
View article: Exploration of effect of metformin in Amyloid beta (1-42) and streptozotocin induced rodent models of Alzheimer's disease
Exploration of effect of metformin in Amyloid beta (1-42) and streptozotocin induced rodent models of Alzheimer's disease Open
Background: Alzheimer's disease is a disease of aging brain. Metabolic disorder like diabetes mellitus can increases the risk of Alzheimer's disease and insulin resistance in brain. Metformin is commonly used in type-II diabetes, which hel…
View article: To evaluate the anti-kindling effect of allopregnanolone alone and its interaction with sodium valporate in pentylenetetrazole induced kindling model
To evaluate the anti-kindling effect of allopregnanolone alone and its interaction with sodium valporate in pentylenetetrazole induced kindling model Open
Background and purpose Studies in the animal models of epilepsy have suggested the anti-seizure effects of neuroactive steroids and its derivatives in kainic acid and pilocarpine induced limbic seizures and status epilepticus in mice, but …
View article: Gastroprotective effect of bezafibrate, a peroxisome proliferator activated receptor α agonist and its mechanism in a rat model of aspirin‐induced gastric ulcer
Gastroprotective effect of bezafibrate, a peroxisome proliferator activated receptor α agonist and its mechanism in a rat model of aspirin‐induced gastric ulcer Open
Summary Background The aim of the present study was to demonstrate the antiulcer activity and mechanism of bezafibrate in a rat model of aspirin‐induced gastric ulcer. Methods We used an aspirin‐induced gastric ulcer model. Bezafibrate was…
View article: MALDI-TOF
MALDI-TOF Open
Among different mass spectrometry, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) has become popular in infectious disease management, infection control and antimicrobial stewardship especially …
View article: Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy
Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy Open
Dear Editor,
Naltrexone is a long-acting, potent, competitive opioid antagonist approved for the treatment of alcohol and opioid dependence at a dose of 50 mg/day [1]. Recently, naltrexone in 1–5 mg OD, typically referred to as low-dose n…
View article: Lercanidipine alleviates hyperalgesia and allodynia in Rodent Model of paclitaxel induced neuropathy
Lercanidipine alleviates hyperalgesia and allodynia in Rodent Model of paclitaxel induced neuropathy Open