Amitha Raman
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View article: The DoGA consortium expression atlas of promoters and genes in 100 canine tissues
The DoGA consortium expression atlas of promoters and genes in 100 canine tissues Open
The dog, Canis lupus familiaris, is an important model for studying human diseases. Unlike many model organisms, the dog genome has a comparatively poor functional annotation, which hampers gene discovery for development, morphology, disea…
View article: Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology Open
Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and smoldering pathology. Although single-cell analyses provided insights into cytopathology, evolving cellular processes underlying MS remain poorly und…
View article: Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human
Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human Open
Background Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiol…
View article: Dog colour patterns explained by modular promoters of ancient canid origin
Dog colour patterns explained by modular promoters of ancient canid origin Open
Distinctive colour patterns in dogs are an integral component of canine diversity. Colour pattern differences are thought to have arisen from mutation and artificial selection during and after domestication from wolves but important gaps r…
View article: Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State
Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State Open
Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. Whether similar mechanisms operate in white adipose tissue (WAT) of obese subjects and to what extent these are normalized by weight loss is unknown. We dete…
View article: Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State
Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State Open
Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. Whether similar mechanisms operate in white adipose tissue (WAT) of obese subjects and to what extent these are normalized by weight loss is unknown. We dete…
View article: Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State
Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State Open
Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. Whether similar mechanisms operate in white adipose tissue (WAT) of those with obesity and to what extent these are normalized by weight loss are unknown. We…
View article: Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth
Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth Open
View article: The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity
The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity Open