Atif Awan
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View article: Serum <i>N</i>-glycosylation is altered in Nephropathic Cystinosis
Serum <i>N</i>-glycosylation is altered in Nephropathic Cystinosis Open
Changes in glycosylation can serve as markers for rare genetic disorders, including lysosomal storage diseases (LSDs). Nephropathic Cystinosis (NC), caused by mutations in the CTNS gene, is characterised by cystine accumulation in lysosome…
View article: Genotype–phenotype correlations and clinical outcomes of genetic <i>TRPC6</i> podocytopathies
Genotype–phenotype correlations and clinical outcomes of genetic <i>TRPC6</i> podocytopathies Open
Background and hypothesis Podocytopathy associated with likely pathogenic/pathogenic variants of Transient receptor potential cation channel subfamily C member 6 (TRPC6) (TRPC6-AP) has been recognized for about 20 years. As a result of its…
View article: Frequency of Survival of Endodontically Treated Teeth Restored With Filling or Crown
Frequency of Survival of Endodontically Treated Teeth Restored With Filling or Crown Open
The long-term success of endodontically treated teeth significantly depends on the quality of the final restoration. Whether direct (fillings) or indirect (crowns), restorations are critical in protecting tooth structure and preventing rei…
View article: Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohort
Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohort Open
View article: Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury
Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury Open
Introduction Neonatal sepsis remains a leading cause of morbidity and mortality across all healthcare systems. Acute kidney injury (AKI) is common in neonates and is associated with poor clinical outcomes. We sought to profile the incidenc…
View article: Employing a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus
Employing a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus Open
Aim This study hypothesised that infants with a haemodynamically significant patent ductus arteriosus (hsPDA) as defined by a validated score have a higher incidence of acute kidney injury (AKI). Methods A retrospective study was conducted…
View article: Assessing the supportive care needs of parents of children with rare diseases in Ireland
Assessing the supportive care needs of parents of children with rare diseases in Ireland Open
View article: A Systematic Review of the Incidence of Acute Kidney Injury in Infants with Patent Ductus Arteriosus
A Systematic Review of the Incidence of Acute Kidney Injury in Infants with Patent Ductus Arteriosus Open
Purpose of Review Acute kidney injury (AKI) is common and associated with poor clinical outcomes in neonates, affecting nearly a third of infants admitted to a neonatal intensive care unit (NICU). Premature infants and infants with very lo…
View article: Retrospective database analysis on the demographics and resource utilization of patients with Parkinson’s disease in Quebec, Canada
Retrospective database analysis on the demographics and resource utilization of patients with Parkinson’s disease in Quebec, Canada Open
Many pharmacological options exist for PD patients and, though patients are adherent while on therapy, treatment discontinuation rates are high. This suggests potential long-term challenges in PD management, especially since PD continues t…
View article: Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences?
Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences? Open
Background There is a lack of information on the current healthcare systems for children with kidney diseases across Europe. The aim of this study was to explore the different national approaches to the organization and delivery of pediatr…
View article: Diagnostic Challenges in Rhino-Orbito-Cerebral Mucormycosis With Diabetes Mellitus, Hypertensive Emergency, and Excess Alcohol Consumption
Diagnostic Challenges in Rhino-Orbito-Cerebral Mucormycosis With Diabetes Mellitus, Hypertensive Emergency, and Excess Alcohol Consumption Open
View article: Valvular Heart Disease Care in Pakistan
Valvular Heart Disease Care in Pakistan Open
View article: Recurrent Hypophosphatemia Following a Single Dose of Parenteral Iron Administration
Recurrent Hypophosphatemia Following a Single Dose of Parenteral Iron Administration Open
Although parenteral iron is widely used to treat iron deficiency anemia (IDA), some side effects have been inadequately explored. Hypophosphatemia is becoming a well-documented, yet poorly understood, side effect of parenteral iron infusio…
View article: Type IV-Collagen associated nephropathy—a form of nephrotic syndrome
Type IV-Collagen associated nephropathy—a form of nephrotic syndrome Open
View article: Risk of cellular or antibody-mediated rejection in pediatric kidney transplant recipients with BK polyomavirus replication—an international CERTAIN registry study
Risk of cellular or antibody-mediated rejection in pediatric kidney transplant recipients with BK polyomavirus replication—an international CERTAIN registry study Open
Background In kidney transplant recipients (KTR), BK polyomavirus-associated nephropathy (BKPyVAN) is a major cause of graft loss. To facilitate the clearance of BKPyV-DNAemia, reduction of immunosuppression is currently the treatment of c…
View article: Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum
Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum Open
View article: Torque Teno Virus Loads as a Marker of Immunosuppression in Pediatric Kidney Transplant Recipients
Torque Teno Virus Loads as a Marker of Immunosuppression in Pediatric Kidney Transplant Recipients Open
Background Long‐term renal function and survival after kidney transplantation rely on appropriate immunosuppressive treatment to prevent the risk of rejection. New biomarkers are needed to accurately assess the degree of immunosuppression …
View article: Incidence, risk factors, management strategies, and outcomes of antibody-mediated rejection in pediatric kidney transplant recipients—a multicenter analysis of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN)
Incidence, risk factors, management strategies, and outcomes of antibody-mediated rejection in pediatric kidney transplant recipients—a multicenter analysis of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) Open
View article: Age-Related Differences in Rejection Rates, Infections, and Tacrolimus Exposure in Pediatric Kidney Transplant Recipients in the CERTAIN Registry
Age-Related Differences in Rejection Rates, Infections, and Tacrolimus Exposure in Pediatric Kidney Transplant Recipients in the CERTAIN Registry Open
This is the largest study to date in European pKTRs on a tacrolimus-based immunosuppressive regimen, and it shows important age-related differences in rejection rates, infection episodes, as well as tacrolimus exposure and clearance. This …
View article: Age-related differences in rejection rates, infections and tacrolimus exposure in pediatric kidney transplant recipients – a benchmark study of the CERTAIN registry
Age-related differences in rejection rates, infections and tacrolimus exposure in pediatric kidney transplant recipients – a benchmark study of the CERTAIN registry Open
Background Data on age-related differences in rejection rates, infectious episodes and tacrolimus exposure in pediatric kidney transplant recipients (pKTR) on a uniform tacrolimus-based immunosuppressive regimen are scarce. Methods We ther…
View article: An unusual case of nephrotic syndrome
An unusual case of nephrotic syndrome Open
Background Alport syndrome is a genetically heterogenous disorder resulting from variants in genes coding for alpha-3/4/5 chains of Collagen IV, which results in defective basement membranes in the kidney, cochlea and eye. The syndrome has…
View article: Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation
Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation Open
The degree of metabolic acidosis is associated with allograft dysfunction.
View article: Incidence, risk factors, management strategies and outcomes of antibody-mediated rejection in pediatric kidney transplant recipients – a multicenter analysis of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN)
Incidence, risk factors, management strategies and outcomes of antibody-mediated rejection in pediatric kidney transplant recipients – a multicenter analysis of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) Open
Background. This study by the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) was designed to determine the incidence, risk factors, current management strategies and outcomes of antibody-mediated rejection (ABMR) in …
View article: Diversity of kidney care referral pathways in national child health systems of 48 European countries
Diversity of kidney care referral pathways in national child health systems of 48 European countries Open
Background Primary, secondary and tertiary healthcare services in Europe create complex networks covering pediatric subspecialties, sociology, economics and politics. Two surveys of the European Society for Paediatric Nephrology (ESPN) in …
View article: The use of art as a creative research method to understand psychosocial care needs for children with rare diseases
The use of art as a creative research method to understand psychosocial care needs for children with rare diseases Open
Background: Even though a disease might be labelled as ‘rare’, it is estimated that 450 million people globally are affected by rare diseases, and 70% of these conditions are among children. All children have the right to good quality heal…
View article: Histopathological Spectrum and Clinical Correlation of Gastrointestinal Mucosal Biopsies in Patients with Chronic Diarrhea. A Cross-Sectional Study
Histopathological Spectrum and Clinical Correlation of Gastrointestinal Mucosal Biopsies in Patients with Chronic Diarrhea. A Cross-Sectional Study Open
Background: Chronic diarrhea, defined as diarrhea lasting four weeks or more, is a common clinical problem with a wide range of etiologies. Its causes may include infectious, inflammatory, autoimmune, and neoplastic conditions. While clini…
View article: Longitudinal analysis of the impact of rituximab on circulating EBV miRNAs in three paediatric kidney transplant recipients
Longitudinal analysis of the impact of rituximab on circulating EBV miRNAs in three paediatric kidney transplant recipients Open
Background: EBV DNA monitoring is currently the main strategy to identify renal transplant recipients potentially at risk of EBV complications. EBV miRNA expression is markedly altered in different disease presentations associated with EBV…
View article: KCNJ16 associated Hypokalaemic Tubulopathy and Deafness presenting with Sudden Cardiac Arrest.
KCNJ16 associated Hypokalaemic Tubulopathy and Deafness presenting with Sudden Cardiac Arrest. Open
Inwardly rectifying potassium channels (K ir ) allow potassium (K+) to easily move into cells. They are implicated in several diverse physiological processes throughout the body. KCNJ16 associated tubulopathy and deafness affects a subset …
View article: European chronic kidney disease registries for children not on kidney replacement therapy: tools for improving health systems and patient-centred outcomes
European chronic kidney disease registries for children not on kidney replacement therapy: tools for improving health systems and patient-centred outcomes Open
Chronic kidney disease (CKD) in children, from birth to late adolescence, is a unique and highly challenging condition that requires epidemiological research and large-scale, prospective cohort studies. Since its first launch in 2007, the …
View article: Hyperparathyroidism Is an Independent Risk Factor for Allograft Dysfunction in Pediatric Kidney Transplantation
Hyperparathyroidism Is an Independent Risk Factor for Allograft Dysfunction in Pediatric Kidney Transplantation Open