Amol Gadbail
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View article: Development of a core outcome set for trials for management of oral submucous fibrosis (OSFCOS): A consensus study protocol
Development of a core outcome set for trials for management of oral submucous fibrosis (OSFCOS): A consensus study protocol Open
Background The effectiveness of oral submucous fibrosis (OSF) treatment is currently assessed with a broad range of clinical outcome measures. This heterogeneity complicates study comparison, synthesis of results, and evidence-based clinic…
Evaluation and Correlation of 17β-Estradiol in Blood and Estrogen Receptor α (ERα) and Estrogen Receptor β(ER β) in Tissue of Oral Squamous Cell Carcinoma Open
The levels of E2 can be used as a marker in predicting the progression of disease from normal tissue not exposed to tobacco to normal tissue exposed to tobacco to premalignant to OSCC. The ERα in tissue is positively correlated with the in…
The Oral Health Status of Intellectually and Physically Challenged Children in Central India- A Comparison Study Open
Introduction: Developmental disabilities includes Down’s syndrome, cerebral palsy, mental retardation, hearing and visual impairments. They present with compromised oral hygiene. Hence, this study was aimed to study oral hygiene status of …
Physiotherapy in improving the interincisal mouth opening in oral submucous fibrosis: Meta-analysis Open
There is evidence of effectiveness of physiotherapy in improving the IMO. However, evidence need to be substantiated with stringent methodology which is lacking in most of studies.
A prospective study of circulating estrogen in oral leukoplakia and oral squamous cell carcinoma Open
Background: Reports suggested that hormone replacement therapy decreased the incidence of squamous cell carcinoma (SCC) of the oral cavity. Aim: The aim of this study was to analyze and quantify the serum 17β-estradiol (E2) level by chemil…
Malignant transformation in oral submucous fibrosis: Tertiary level evidence: An umbrella review Open
Objectives An umbrella review is a systematic review of systematic reviews, which provides a tertiary level of evidence. This umbrella review of systematic reviews and meta‐analysis (SR‐MA) aimed to determine the proportion of oral cancer …
Preclinical methodologies for studying smokeless tobacco-induced oral carcinogens: A perspective Open
Understanding the carcinogenesis mechanism of different carcinogenic agents is paramount for implementing preventive and therapeutic strategies for cancer. Hence, an appropriate simulation of the clinical situation in preclinical studies s…
Ki-67, CD105, and α-smooth muscle actin expression in oral squamous cell carcinoma corresponds with different forms of tobacco consumption habits Open
Background: Association with variety of etiological agents is one of the characteristic features of oral squamous cell carcinoma (OSCC). We hypothesized the existence of tobacco consumption habit-based heterogeneity in the immunohistochemi…
Significance of HIF-1α and CD105 in establishing oral squamous cell carcinoma associated with oral submucous fibrosis a distinct clinicopathological entity Open
Context: Oral squamous cell carcinoma associated with oral submucous fibrosis (OSCC with OSMF) is clinicopathologically a distinct entity. However, scientific proof in view of assessment of biomarkers of hypoxia and neoangiogenesis to diff…
Prevalence and Pattern of Self-medication with Alternative Medicine Open
Aim: The aim of this study was to investigate prevalence and pattern of self-medication with alternative medicine (ALM) among oral submucous fibrosis (OSF) patients with emphasis on treatment-switch analysis. Methods: A total of 115 OSF pa…
Prevalence of Trismus and Its Impact on Oral Health-Related Quality of Life in Patients Treated for Oral Squamous Cell Carcinoma Open
Oral squamous cell carcinoma, one of the most common malignancies, has a poor prognosis due to impairment in oral functions secondary to treatment. Trismus one of the major causes of impairment of oral function. The present study investiga…
The Impact of COVID-19 on General and Dental Health Open
COVID-19 (Coronavirus disease 2019) is a contagious infection caused by novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). This novel virus was publicly announced as an infectious pathogen by the “Chinese Centr…
Why do Only Certain Cases of Oral Submucous Fibrosis Undergo Malignant Transformation? Open
Oral submucous fibrosis (OSMF) causes desmoplasia and rigidity of submucosa of the oral cavity, resulting in reduced mouth opening, and in advanced stage causes difficulty in swallowing. OSMF has poor morbidity in terms of oral function as…
Impact of Oral Lichen Planus on Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis Open
Oral health-related quality of life (OR-QoL) measurement in patients with oral lichen planus (OLP) can provide valuable information for the optimal management of their clinical conditions. The main objective of the present study was to ass…
A compendium of population wide DNA methylation profile for oral cancer in India Open
With the emergence of epigenetics, constant attempts are been made to decipher the molecular mechanisms in carcinogenesis. Epigenetic modifications, especially the DNA methylation, have been perceived in oral squamous cell carcinoma (OSCC)…
Oral Psychosomatic Disorders in Family Caregivers of Oral Squamous Cell Carcinoma Patients Open
The observations of higher prevalence of oral PSDs in FCs with psychological alterations can enhance healthcare professionals' awareness to better understand FCs' oral healthcare needs..
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma Open
The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC.
Cucurbitacin: As a candidate against Cytokine Storm in Severe COVID-19 Infection Open
The severity of SARS-CoV-2 infection is marked by elevated cytokines and chemokines levels like interleukin 6 (IL-6), interferon-gamma (IFN-γ), tumour necrosis factor (TNF), IL-2 and monocyte chemotactic protein 1. This hyperactive pro-inf…